Associations between anxiolytic medications and ventral hernia repair
This study examines the relationship between anxiolytic medications (AXM) on outcomes following ventral hernia repair.
A single-center review of prospectively obtained perioperative and 30-day outcome data, including AXM use at admission, as part of the National Surgery Quality Improvement Program.
Sixty-three of the 393 patients who presented for ventral hernia repair were taking an AXM (15.6%). AXM users were more likely to have a higher ASA class, dyspnea, and treated hypertension (p < 0.05). AXM use was associated with increased operative duration, hernia size, increased estimated blood loss, and need for component separation. After adjusting for medical comorbidities, AXM users were not found to have greater 30-day morbidity or mortality. Patients taking AXM were found to have greater length of stay and increased hospital readmissions.
Patients taking anxiolytic medications undergoing ventral hernia repairs have higher ASA scores, more complex hernia characteristics, and require more concurrent procedures. They were found to have longer operative times, increased blood loss, greater duration of hospital stay, and increased readmissions that were associated with the increased perioperative risk factors. Further studies are required to determine causal links.
KeywordsVentral hernia Anxiolytics NSQIP Hospital readmissions Perioperative risk factors
Compliance with ethical standards
Conflict of interest
Drs. Neff, Totten, Plymale, Oyler, and Davenport declare no conflicts of interest. Dr. Roth declares conflict of interest not directly related to the submitted work: grants, personal fees, and other from Bard; grants, personal fees, and other from Acelity; grants from Miromatrix, and grants from MTF.
The University of Kentucky Medical Institutional Review Board reviewed and approved this study.
Statement of human rights
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
For this study, formal consent was not required.
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