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A rare case of oligodendroglioma with gangliocytic differentiation in a 31-year-old male: importance of genetic testing for IDH1/2

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Abstract

We report a rare case of oligodendroglioma with gangliocytic differentiation. A 31-year-old male without a past medical history was admitted with a sudden seizure. On magnetic resonance imaging, an approximately 7-cm mass with necrosis was noted in the right frontal lobe. The patient underwent surgical resection. On microscopy, two morphologically distinct areas with oligodendroglioma- and ganglioglioma-like features were found. Immunohistochemistry showed an absence of CD34 expression, whereas isocitrate dehydrogenase 1 (IDH1) was positive in the glial component. Moreover, IDH1 was positive in the ganglion-like cells as well as in the glial component. Subsequent 1p/19q co-deletion was confirmed by fluorescence in situ hybridization. Finally, a diagnosis of oligodendroglioma with gangliocytic differentiation was made. IDH1/2 molecular test would be basic and essential diagnostic tool in central nervous system tumor of young patients.

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Authors and Affiliations

  1. Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

    Ji Hyun Park & Yoon Jin Cha

  2. Department of Neurosurgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

    Jong Hee Chang

  3. Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea

    Seung-Koo Lee

  4. Department of Pathology, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea

    Se Hoon Kim

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  1. Ji Hyun Park
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  2. Yoon Jin Cha
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  4. Seung-Koo Lee
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Correspondence to Se Hoon Kim.

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The current case was presented as an oral presentation at the 19th International Congress of Neuropathology in 2018, Tokyo.

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Park, J.H., Cha, Y.J., Chang, J.H. et al. A rare case of oligodendroglioma with gangliocytic differentiation in a 31-year-old male: importance of genetic testing for IDH1/2. Brain Tumor Pathol 37, 95–99 (2020). https://doi.org/10.1007/s10014-020-00368-w

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  • DOI: https://doi.org/10.1007/s10014-020-00368-w

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