Brain Tumor Pathology

, Volume 35, Issue 2, pp 114–122 | Cite as

Three case reports of radiation-induced glioblastoma after complete remission of acute lymphoblastic leukemia

  • Takumi Kajitani
  • Masayuki Kanamori
  • Ryuta Saito
  • Yuko Watanabe
  • Hiroyoshi Suzuki
  • Mika Watanabe
  • Shigeo Kure
  • Teiji Tominaga
Case Report


Radiation therapy is sometimes performed to control intracranial acute lymphoblastic leukemia (ALL), but may lead to radiation-induced malignant glioma. The clinical, radiological, histological, and molecular findings are described of three cases of radiation-induced glioblastoma after the treatment for ALL. They received radiation therapy at age 6–8 years. The latency from radiation therapy to the onset of radiation-induced glioblastoma was 5–10 years. Magnetic resonance imaging demonstrated diffuse lesions with multiple small enhanced lesions in all cases. Histological examination showed that the tumors consisted of mainly small round astrocytic atypical cells in one case, and astrocytic atypical cells with elongated cytoplasm and nuclear pleomorphism with small cell component in two cases. Microvascular proliferation was present in all cases. Immunohistochemical analysis for B-Raf V600E, and mutational analysis for the isocitrate dehydrogenase (IDH) 1, IDH2, and H3F3A gene revealed the wild-type alleles in all three cases. The integrated diagnoses were IDH wild-type glioblastoma, and local irradiation and concomitant temozolomide were performed. After the initial treatment, significant shrinkage of the diffuse lesion and enhanced lesion was found in all cases. Radiation-induced glioblastoma occurring after the treatment for ALL had unique clinical, radiological, histological, and molecular characteristics in our three cases.


Acute lymphoblastic leukemia Radiation-induced glioblastoma Clinicopathological findings 


Compliance with ethical standards

Conflict of interest

These authors declare that they have no conflict of interest.


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Copyright information

© The Japan Society of Brain Tumor Pathology 2018

Authors and Affiliations

  • Takumi Kajitani
    • 1
  • Masayuki Kanamori
    • 1
  • Ryuta Saito
    • 1
  • Yuko Watanabe
    • 2
  • Hiroyoshi Suzuki
    • 3
  • Mika Watanabe
    • 4
  • Shigeo Kure
    • 2
  • Teiji Tominaga
    • 1
  1. 1.Department of Neurosurgery, Graduate School of MedicineTohoku UniversitySendaiJapan
  2. 2.Department of Pediatrics, Graduate School of MedicineTohoku UniversitySendaiJapan
  3. 3.Department of Pathology and Laboratory MedicineNational Hospital Organization Sendai Medical CenterSendaiJapan
  4. 4.Department of PathologyTohoku University HospitalSendaiJapan

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