Brain Tumor Pathology

, Volume 34, Issue 1, pp 28–35 | Cite as

The clinicopathological features of liponeurocytoma

  • Li Xu
  • Jiang Du
  • Junmei Wang
  • Jingyi Fang
  • Zhaoxia Liu
  • Yanjiao He
  • Guilin Li
Original Article


To discuss the clinicopathological features of liponeurocytoma, we retrospectively reviewed three liponeurocytoma cases and compared their immunophenotypes and genotypes with those of similar tumors. Furthermore, we reviewed the literature and compared the similarities and differences between cerebellar and intraventricular liponeurocytomas. Two cerebellar and one intraventricular liponeurocytomas were included in the present study. The liponeurocytomas comprised small tumor cells and lipomatous cells. The tumor cells expressed SYN, MAP-2, and NeuN. One case showed atypical histological features. By reviewing the literature, we found that cerebellar liponeurocytoma tended to be more common in females, whereas the converse was true for intraventricular liponeurocytoma. Compared with cerebellar liponeurocytoma, intraventricular liponeurocytoma was more commonly noted in younger adult patients. A high MIB-1 index (>10%) and incomplete tumor resection might represent adverse prognostic factors in patients with liponeurocytoma. We suggest that ‘central liponeurocytoma’ should be used to include all putative liponeurocytoma sites. The present study identified several morphological, immunohistochemical, and genetic features that may aid in the differential diagnosis of liponeurocytoma. In addition, surgery should be the preferred treatment, and complete tumor resection should be the goal. Additional cases with long-term follow-up are needed to develop optimal management protocols for liponeurocytoma.


Liponeurocytoma Neurocytoma Glioma Embryonal tumor Immunohistochemistry 



This work was supported by Grants from the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (2013BAI09B03) and Beijing Institute for Brain Disorders (BIBD-PXM2013_014226_07_000084).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© The Japan Society of Brain Tumor Pathology 2017

Authors and Affiliations

  • Li Xu
    • 1
  • Jiang Du
    • 1
  • Junmei Wang
    • 1
  • Jingyi Fang
    • 1
  • Zhaoxia Liu
    • 1
  • Yanjiao He
    • 1
  • Guilin Li
    • 1
  1. 1.Department of Neuropathology, Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical UniversityChina National Clinical Research Center for Neurological Diseases (NCRC-ND), Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Brain TumorBeijingChina

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