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Primary Ewing’s sarcoma of the orbit: case report

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Abstract

A 22-year-old man presented with tenderness and swelling of the left lateral part of the orbit. Computed tomography revealed a left intraorbital mass measuring 3 cm × 3 cm involving the left lateral wall of the orbit and the greater wing of the left sphenoid bone. Magnetic resonance imaging revealed that the intraorbital mass was extraneuroaxial. During surgery, the tumor was seen to arise from the lateral wall of the orbit and infiltrate into the left temporal muscle. Following the surgery, the patient was administered radiation therapy for the whole cranium and chemotherapy for the residual tumors. However, the tumor recurred, and the patient died about 2 years following the first surgery because the tumor had metastasized to the lung. On light microscopy, the tumor cells were closely packed with uniform, small, and round cells. Immunohistochemical studies showed that the tumor cell membrane stained positive for MIC2. Furthermore, the MIB-1 labeling index was 36.2%. On electron microscopy, small quantities of cytoplasm containing glycogen accumulations without neurosecretory granules and neurofilaments were observed. Based on these results, the tumor was diagnosed to be primary Ewing’s sarcoma. Primary orbital Ewing’s sarcoma of the skull has been considered to be extremely rare, and a review of the literature was performed.

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Author notes

  1. Tomoaki Kano

    Present address: , 903 Apagardens, Takasakiekimae 149-3 Yajima, Takasaki, Gunma, 370-0849, Japan

Authors and Affiliations

  1. Department of Neurosurgery, Gunma University Graduate School of Medicine, Gunma, Japan

    Tomoaki Kano, Shinichiro Tomizawa, Takashi Shibasaki, Masaru Tamura & Chihiro Ohye

  2. Department of Human Pathology, Gunma University Graduate School of Medicine, Gunma, Japan

    Atsushi Sasaki

Authors
  1. Tomoaki Kano
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  2. Atsushi Sasaki
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  3. Shinichiro Tomizawa
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  4. Takashi Shibasaki
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  5. Masaru Tamura
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  6. Chihiro Ohye
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Correspondence to Tomoaki Kano.

Additional information

This case was presented at the 15th annual meeting of the Japan Society of Brain Tumor Pathology, 1997

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Kano, T., Sasaki, A., Tomizawa, S. et al. Primary Ewing’s sarcoma of the orbit: case report. Brain Tumor Pathol 26, 95–100 (2009). https://doi.org/10.1007/s10014-009-0256-x

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  • DOI: https://doi.org/10.1007/s10014-009-0256-x

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