Journal of Solid State Electrochemistry

, Volume 22, Issue 5, pp 1431–1438 | Cite as

Electrochemical sensor for estriol hormone detection in biological and environmental samples

  • Letícia Vieira Jodar
  • Fabrício Aparecido Santos
  • Valtencir Zucolotto
  • Bruno Campos Janegitz
Original Paper


A stable conducting film for sensing using reduced graphene oxide (RGO), gold nanoparticles (GNPs), and potato starch (PS) is proposed. The characterization of the nanomaterials was obtained by ultraviolet and visible spectroscopy, dynamic light scattering, zeta potential, Fourier transform infrared spectroscopy, atomic force microscopy, and cyclic voltammetry. The voltammetric behavior of the RGO-GNPs-PS/GCE electrodes was studied in the presence of estriol and the results showed a high anodic peak current at 0.64 V. Under optimal conditions, an analytical curve was obtained, in which the anodic peak estriol was linear in the range from 1.5 to 22 μmol L−1, with a detection limit of 0.48 μmol L−1. The modified electrodes were applied for determination of estriol in environmental and biological samples. The proposed electrode was used for estriol determination in water and urine samples, which presented a recovery range from 92.1 to 106%, showing that RGO-GNPs-PS/GCE is a viable alternative for the detection of estriol and can be attractive for several electrochemical applications.


Electrochemistry Potato starch Metal nanoparticles Estriol Sensors 



We would like to thank the financial support and scholarships from Brazilian funding agencies FAPESP (2015/19099-2), CNPq (2016/119884-0), and CAPES.


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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.Department of Nature Sciences, Mathematics and EducationFederal University of São CarlosArarasBrazil
  2. 2.Nanomedicine and Nanotoxicology Group, Institute of PhysicsUniversity of São PauloSão CarlosBrazil

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