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Development and endoscopic appearance of colorectal tumors are characterized by the expression profiles of miRNAs

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Abstract

Accumulating data indicates that certain microRNAs (miRNAs or miRs) are differently expressed in samples of tumors and paired non-tumorous samples taken from the same patients with colorectal tumors. We previously reported to clarify the relationship between the expression of the miRNAs and the endoscopic morphological appearance of the colorectal tumors. In this report, we focused on colorectal adenoma (tubular or tubulovillous adenoma), or tubular early carcinoma or type 2 adenocarcinoma, familial adenomatous polyposis (FAP), ulcerative colitis-associated tumor (UCAT), and sessile serrated adenoma/polyp (SSA/P). We tried to clarify the relationship between the expression of the miRNAs and the colorectal tumor development. The expression levels of miR-143, -145, and -34a were reduced in most of the polypoid and FAP tumors compared with those in the flat elevated, UCAT, SSA/P ones. In type 2 adenocarcinomas, the expression profile of these miRNAs was similar to those of the polypoid and FAP tumors. The expression levels of miR-7 and -21 were up-regulated in non-granular type of laterally spreading tumor, UCAT, and SSA/P compared with those in polypoid and FAP tumors. These findings indicated that the expression of onco-related miRNAs was closely associated with the development and endoscopic appearance of colorectal tumors.

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Acknowledgements

This study was supported by grants from Fujita Health University and the staff of the Gastroenterology Department of Fujita Heath University and by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture of Japan.

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Authors and Affiliations

  1. Department of Gastroenterology, School of Medicine, Fujita Health University, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan

    Yoshihito Nakagawa, Tomomitsu Tahara, Hiromi Yamashita, Mitsuo Nagasaka, Tomoyuki Shibata & Naoki Ohmiya

  2. The United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, 501-1193, Japan

    Yukihiro Akao

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  1. Yoshihito Nakagawa
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  2. Yukihiro Akao
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  3. Tomomitsu Tahara
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Correspondence to Yoshihito Nakagawa.

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Nakagawa, Y., Akao, Y., Tahara, T. et al. Development and endoscopic appearance of colorectal tumors are characterized by the expression profiles of miRNAs. Med Mol Morphol 51, 82–88 (2018). https://doi.org/10.1007/s00795-018-0186-y

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