Medical Molecular Morphology

, Volume 51, Issue 2, pp 118–127 | Cite as

Effects of moderate exercise on biochemical, morphological, and physiological parameters of the pancreas of female mice with estrogen deprivation and dyslipidemia

  • Aparecida Gabriela Bexiga Veloso
  • Nathalia Edviges Alves Lima
  • Elisabete de Marco Ornelas
  • Clever Gomes Cardoso
  • Mara Rubia Marques
  • Beatriz da Costa Aguiar Alves Reis
  • Fernando Luiz Affonso Fonseca
  • Laura Beatriz Mesiano Maifrino
Original Paper

Abstract

Menopausal women are at high risk of developing heart disease. However, physical exercise practice can reverse this scenario. We evaluated the biochemical, morphological, and physiological effects of moderate aerobic physical exercise on the pancreas of knockout mice for LDL receptor with estrogen deprivation by ovariectomy. Animals were divided into six groups (n = 5): sedentary non-ovariectomized control; sedentary ovariectomized control; trained ovariectomized control; sedentary non-ovariectomized LDL-R knockout; sedentary ovariectomized LDL-R knockout; and trained ovariectomized LDL-R knockout. Physical exercise practice promoted improvement in biometric and biochemical parameters analyzed, with reduction of visceral adipose tissue and VLDL, triglycerides, total cholesterol, and blood glucose levels. In addition, physical exercise practice altered the morphology of pancreatic islets and improved their response to the effects of menopause. Thus, physical exercise practice was fundamental to minimize the effects of dyslipidemia associated with ovariectomy in the pancreatic tissue of LDL-R knockout animals, contributing to reduce the risk of developing cardiac diseases in the menopause period.

Keywords

Dyslipidemia Pancreas Physical exercise Menopause Estrogen deprivation 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

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Copyright information

© The Japanese Society for Clinical Molecular Morphology 2018

Authors and Affiliations

  • Aparecida Gabriela Bexiga Veloso
    • 1
  • Nathalia Edviges Alves Lima
    • 1
  • Elisabete de Marco Ornelas
    • 1
  • Clever Gomes Cardoso
    • 2
  • Mara Rubia Marques
    • 2
  • Beatriz da Costa Aguiar Alves Reis
    • 3
  • Fernando Luiz Affonso Fonseca
    • 3
    • 4
  • Laura Beatriz Mesiano Maifrino
    • 1
  1. 1.Laboratório de Estudos Morfoquantitativo e Imunohistoquímico da USJTSão PauloBrazil
  2. 2.Universidade Federal de GoiásGoiâniaBrazil
  3. 3.Laboratório de Análises Clínicas da Faculdade de Medicina do ABCSanto AndréBrazil
  4. 4.Departamento de Ciências Farmacêuticas da Universidade Federal de São PauloDiademaBrazil

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