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Molecular morphology of the digestive tract; macromolecules and food allergens are transferred intact across the intestinal absorptive cells during the neonatal-suckling period

  • SPECIAL REVIEW SERIES: Molecular morphological approach for pathogenesis of hepatogastrointestinal diseases
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Abstract

Food allergies represent an important medical problem throughout the developed world. The epithelium of the digestive tract is an important area of contact between the organism and its external environment. Accordingly, we must reconsider the transport of intestinal transepithelial macromolecules, including food allergens, in vivo. The intestinal epithelium of the neonatal-suckling rat is a useful model system for studies into endocytosis and transcytosis. Macromolecules and food allergens can be transferred intact with maternal immunoglobulins across the absorptive cells of duodenum and jejunum during the neonatal-suckling period. This review summarizes these observations as well as our recent molecular morphological studies.

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References

  1. RR Cardell SuffixJr S Badenhausen KR Porter (1967) ArticleTitleIntestinal triglyceride absorption in the rat. An electron microscopical study J Cell Biol 34 123–155 Occurrence Handle6033529 Occurrence Handle10.1083/jcb.34.1.123 Occurrence Handle1:CAS:528:DyaF2sXksFWrsbY%3D

    Article  PubMed  CAS  Google Scholar 

  2. WA Walker R Cornell LM Davenport KJ Isselbacher (1972) ArticleTitleMacromolecular absorption. Mechanism of horseradish peroxidase uptake and transport in adult and neonatal rat intestine J Cell Biol 54 195–205 Occurrence Handle5040858 Occurrence Handle10.1083/jcb.54.2.195 Occurrence Handle1:CAS:528:DyaE38XksF2msbc%3D

    Article  PubMed  CAS  Google Scholar 

  3. O Koldovský M Dobiášovà P Hahn J Kolinská J Kraml J Pácha (1995) ArticleTitleDevelopment of gastrointestinal functions Physiol Res 44 341–348 Occurrence Handle8798267

    PubMed  Google Scholar 

  4. SL Clark (1959) ArticleTitleThe ingestion of proteins and colloidal materials by columnar absorptive cells of the small intestine in suckling rats and mice J Biophys Biochem Cytol 5 41–49 Occurrence Handle13630932

    PubMed  Google Scholar 

  5. K Bainter (1986) Intestinal absorption of macromolecules and immune transmission from mother to young CRC Press Boca Raton

    Google Scholar 

  6. MG Martin SV Wu JH Walsh (1997) ArticleTitleOntogenetic development and distribution of antibody transport and Fc receptor mRNA expression in rat intestine Dig Dis Sci 42 1062–1069 Occurrence Handle9149063 Occurrence Handle10.1023/A:1018853506830 Occurrence Handle1:CAS:528:DyaK2sXjs1Crtb8%3D

    Article  PubMed  CAS  Google Scholar 

  7. ER Jakoi G Zampighi JD Robertson (1976) ArticleTitleRegular structures in unit membranes. II. Morphological and biochemical characterization of two water-soluble membrane proteins isolated from the suckling rat ileum J Cell Biol 70 91–111 Occurrence Handle10.1083/jcb.70.1.97

    Article  Google Scholar 

  8. JD Robertson S Knutton AR Limbrick ER Jakoi G Zampighi (1976) ArticleTitleRegular structures in unit membranes. III. Further observations on the particulate components of the suckling rat ileum endocytic membrane complexes J Cell Biol 70 112–122 Occurrence Handle58867 Occurrence Handle10.1083/jcb.70.1.112 Occurrence Handle1:CAS:528:DyaE28XksValsr8%3D

    Article  PubMed  CAS  Google Scholar 

  9. M Fujita F Reinhart MR Neutra (1988) ArticleTitleConvergence of apical and basolateral endocytic pathways at the late endosome: double-tracer studies in ileal absorptive cells of suckling rats J Cell Biol 107 110a

    Google Scholar 

  10. M Fujita F Reinhart MR Neutra (1990) ArticleTitleConvergence of apical and basolateral endocytic pathways at apical late endosomes in absorptive cells of suckling rat ileum in vivo J Cell Sci 97 385–394 Occurrence Handle2277098

    PubMed  Google Scholar 

  11. S Hirano K Kataoka (1986) ArticleTitleHistogenesis of the mouse jejunal mucosa, with special reference to proliferative cells and absorptive cells Arch Histol Jpn 49 333–348 Occurrence Handle3800596 Occurrence Handle1:STN:280:DyaL2s%2FpvFansw%3D%3D

    PubMed  CAS  Google Scholar 

  12. O Ricardo MD Castillo PRD Arlyn PMS Arlyn CBS Francoise (1988) ArticleTitleIntestinal maturation in the rat: the role of enteral nutrients J Parenter Enteral Nutr 12 490–495 Occurrence Handle10.1177/0148607188012005490

    Article  Google Scholar 

  13. K Miyamoto K Hase Y Taketani H Minami T Oka Y Nakabou H Hagihara (1992) ArticleTitleDevelopmental changes in intestinal glucose transporter mRNA levels Biochem Biophys Res Commun 183 626–631 Occurrence Handle1550569 Occurrence Handle10.1016/0006-291X(92)90528-S Occurrence Handle1:CAS:528:DyaK38XhslSqtro%3D

    Article  PubMed  CAS  Google Scholar 

  14. K Matsumoto Y Takao S Akazawa M Yano S Uotani E Kawasaki H Takino H Yamasaki S Okuno Y Yamaguchi S Nagataki (1993) ArticleTitleDevelopmental change of facilitative glucose transporter expression in rat embryonal and fetal intestine Biochem Biophys Res 193 1275–1282 Occurrence Handle10.1006/bbrc.1993.1763 Occurrence Handle1:CAS:528:DyaK3sXkvFajtbY%3D

    Article  CAS  Google Scholar 

  15. ES David DS Cingari RP Ferraris (1995) ArticleTitleDietary induction of intestinal fructose absorption in weaning rats Pediatr Res 37 777–782 Occurrence Handle7651763 Occurrence Handle1:CAS:528:DyaK2MXmslyrt70%3D

    PubMed  CAS  Google Scholar 

  16. R Shu ES David RP Ferraris (1997) ArticleTitleDietary fructose enhances intestinal fructose transport and GLUT5 expression in weaning rats Am J Physiol Gastrointest Liver Physiol 272 G446–G453 Occurrence Handle1:CAS:528:DyaK2sXit1Whsb4%3D

    CAS  Google Scholar 

  17. R Shu ES David RP Ferraris (1998) ArticleTitleLuminal fructose modulates fructose transport and GLUT-5 expression in small intestine of weaning rats Am J Physiol 274 IssueIDGastrointest Liver Physiol 37 G232–G239 Occurrence Handle9486174 Occurrence Handle1:CAS:528:DyaK1cXis1yru7s%3D

    PubMed  CAS  Google Scholar 

  18. L Jiang ES David N Espina RP Ferraris (2001) ArticleTitleGLUT-5 expression in neonatal rats: crypt-villus location and age-dependent regulation Am J Physiol Gastrointest Liver Physiol 281 G666–G674 Occurrence Handle11518678 Occurrence Handle1:CAS:528:DC%2BD3MXmvFCntrw%3D

    PubMed  CAS  Google Scholar 

  19. R Baba M Yamami Y Sakuma M Fujita S Fujimoto (2005) ArticleTitleRelationship between glucose transporter and changes in the absorptive system in small intestinal absorptive cells during the weaning process Med Mol Morphol 38 47–53 Occurrence Handle16158180 Occurrence Handle10.1007/s00795-004-0275-y

    Article  PubMed  Google Scholar 

  20. P Kilshaw A Cant (1984) ArticleTitleThe passage of maternal dietary proteins into human breast milk Int Arch Allergy Appl Immunol 75 8–15 Occurrence Handle6746107 Occurrence Handle1:CAS:528:DyaL2cXls1yitLc%3D

    PubMed  CAS  Google Scholar 

  21. S Maeda (1993) ArticleTitleThe concentration of bovine IgG in human breast milk measured using different methods Acta Paediatr 82 1012–1016 Occurrence Handle8155915 Occurrence Handle1:STN:280:DyaK2c3gslahtg%3D%3D

    PubMed  CAS  Google Scholar 

  22. AC Jones EA Miles JO Warner BM Colwell TN Bryant JA Warner (1996) ArticleTitleFetal peripheral blood mononuclear cell proliferative responses to mitogenic and allergenic stimuli during gestation Pediatr Allergy Immunol 7 IssueID3 109–116 Occurrence Handle9116874 Occurrence Handle1:STN:280:DyaK2s7otlWqtw%3D%3D

    PubMed  CAS  Google Scholar 

  23. JS Lebovidge KD Stone FJ Twarog SW Raiselis LA Kalish EP Bailey LC Schneider (2006) ArticleTitleDevelopment of a preliminary questionnaire to assess parental response to children's food allergies Ann Allergy Asthma Immunol 96 IssueID3 472–477 Occurrence Handle16597083

    PubMed  Google Scholar 

  24. HA Perr (2006) ArticleTitleNovel foods to treat food allergy and gastrointestinal infection Curr Allergy Asthma Rep 6 IssueID2 153–159 Occurrence Handle16566866 Occurrence Handle1:CAS:528:DC%2BD28XjvFaktbw%3D

    PubMed  CAS  Google Scholar 

  25. S Prates M Morais-Almeida V Matos V Loureiro J Rosado-Pinto (2006) ArticleTitleIn vitro methods for specific IgE detection on cow's milk allergy Allergol Immunopathol (Madr) 34 IssueID1 27–31 Occurrence Handle10.1157/13084224 Occurrence Handle1:STN:280:DC%2BD287lt1amsg%3D%3D

    Article  CAS  Google Scholar 

  26. SH Sicherer HA Sampson (2006) ArticleTitleFood allergy J Allergy Clin Immunol 117 IssueID2 Suppl Mini-Primer S470–S475 Occurrence Handle16455349 Occurrence Handle10.1016/j.jaci.2005.05.048 Occurrence Handle1:CAS:528:DC%2BD28XhtV2rsr0%3D

    Article  PubMed  CAS  Google Scholar 

  27. P Juvonen (1996) ArticleTitleAllergy development and macromolecular absorption in infants with different feeding regimens during the first three days of life. A three-year prospective follow-up Acta Paediatr 85 1047–1052 Occurrence Handle8888916 Occurrence Handle1:STN:280:DyaK2s%2Fktlyntw%3D%3D

    PubMed  CAS  Google Scholar 

  28. S McClain GA Bannon (2006) ArticleTitleAnimal models of food allergy: opportunities and barriers Curr Allergy Asthma Rep 6 IssueID2 141–144 Occurrence Handle16566864

    PubMed  Google Scholar 

  29. R Baba M Fujita CE Tein M Miyoshi (2002) ArticleTitleEndocytosis by absorptive cells in the middle segment of the suckling rat small intestine Anat Sci Int 77 117–123 Occurrence Handle12418091 Occurrence Handle10.1046/j.0022-7722.2002.00017.x

    Article  PubMed  Google Scholar 

  30. R Rodewald (1970) ArticleTitleSelective antibody transport in the proximal small intestine of the neonatal rat J Cell Biol 45 IssueID3 635–640 Occurrence Handle5459946 Occurrence Handle10.1083/jcb.45.3.635 Occurrence Handle1:CAS:528:DyaE3cXks1Cnsr0%3D

    Article  PubMed  CAS  Google Scholar 

  31. R Rodewald (1972) ArticleTitleIntestinal transport of antibodies in the newborn rat J Cell Biol 58 189–211 Occurrence Handle10.1083/jcb.58.1.189

    Article  Google Scholar 

  32. R Rodewald (1973) ArticleTitleIntestinal transport antibodies in the newborn rat J Cell Biol 58 189–211 Occurrence Handle4726306 Occurrence Handle10.1083/jcb.58.1.189 Occurrence Handle1:CAS:528:DyaE3sXks1Cgu7w%3D

    Article  PubMed  CAS  Google Scholar 

  33. R Rodewald (1980) ArticleTitleDistribution of immunoglobulin G receptor in the small intestine of the young rat J Cell Biol 85 18–32 Occurrence Handle7364873 Occurrence Handle10.1083/jcb.85.1.18 Occurrence Handle1:STN:280:DyaL3c7mtVWnug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  34. DR Abrahamson R Rodewald (1981) ArticleTitleEvidence for the sorting of endocytic vesicle contents during receptor-mediated transport of IgG across newborn rat intestine J Cell Biol 91 270–280 Occurrence Handle7298722 Occurrence Handle10.1083/jcb.91.1.270 Occurrence Handle1:CAS:528:DyaL3MXlvVGntb0%3D

    Article  PubMed  CAS  Google Scholar 

  35. HJ Geuze JW Slot GJAM Strous HF Lodish AL Schwartz (1983) ArticleTitleIntracellular site of asialoglycoprotein receptor-ligand uncoupling: double-label immunoelectron microscopy during receptor-mediated endocytosis Cell 32 277–287 Occurrence Handle6130851 Occurrence Handle10.1016/0092-8674(83)90518-4 Occurrence Handle1:CAS:528:DyaL3sXos1OrsQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  36. R Rodewald JP Kraehenbuhl (1984) ArticleTitleReceptor-mediated transport of IgG J Cell Biol 99 IssueID1 159–164 Occurrence Handle10.1083/jcb.99.1.159s

    Article  Google Scholar 

  37. C Harding MA Levy P Stahl (1985) ArticleTitleMorphological analysis of ligand uptake and processing: the role of multivesicular endosomes and CURL in receptor-ligand processing Eur J Cell Biol 36 230–238 Occurrence Handle2986980 Occurrence Handle1:STN:280:DyaL2M3gtl2lsg%3D%3D

    PubMed  CAS  Google Scholar 

  38. TE Staley LJ Bush (1985) ArticleTitleReceptor mechanism of the neonatal intestine and their relationship to immunoglobulin absorption and disease J Dairy Sci 68 184–205 Occurrence Handle3884680 Occurrence Handle1:STN:280:DyaL2M7lvVCksw%3D%3D Occurrence Handle10.3168/jds.S0022-0302(85)80812-2

    Article  PubMed  CAS  Google Scholar 

  39. DO Graney (1968) ArticleTitleThe uptake of ferritin by ileal absorptive cells in suckling rats. An electron microscopic study Am J Anat 123 227–254 Occurrence Handle5701162 Occurrence Handle10.1002/aja.1001230202 Occurrence Handle1:STN:280:DyaF1M%2FnslylsA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  40. CC Chase EA Munn (1980) ArticleTitleSurface binding and uptake of polycationic ferritin by neonatal piglet intestinal epithelium J Cell Sci 46 235–252 Occurrence Handle7228910 Occurrence Handle1:STN:280:DyaL3M7ptF2qug%3D%3D

    PubMed  CAS  Google Scholar 

  41. PA Gonnella MR Neutra (1984) ArticleTitleMembrane-bound and fluid-phase macromolecules enter separate prelysosomal compartments in absorptive cells of suckling rat ileum J Cell Biol 99 909–917 Occurrence Handle6470044 Occurrence Handle10.1083/jcb.99.3.909 Occurrence Handle1:CAS:528:DyaL2cXlsVyrsrw%3D

    Article  PubMed  CAS  Google Scholar 

  42. NK Gonatas SU Kim A Stieber S Avrameas (1977) ArticleTitleInternalization of lectins in neuronal GERL J Cell Biol 73 1–13 Occurrence Handle856827 Occurrence Handle10.1083/jcb.73.1.1 Occurrence Handle1:CAS:528:DyaE2sXhtFynu7o%3D

    Article  PubMed  CAS  Google Scholar 

  43. PA Gonnella MR Neutra (1985) ArticleTitleGlycoconjugate distribution and mobility on apical membranes of absorptive cells of suckling rat ileum in vivo Anat Rec 213 520–528 Occurrence Handle4083533 Occurrence Handle10.1002/ar.1092130408 Occurrence Handle1:CAS:528:DyaL28Xms1KgsQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  44. T Hatae M Fujita K Okuyama (1988) ArticleTitleStudy on the origin of apical tubules in ileal absorptive cells of suckling rats using concanavalin-A as a membrane-bound tracer Cell Tissue Res 251 511–521 Occurrence Handle3365748 Occurrence Handle10.1007/BF00213998 Occurrence Handle1:STN:280:DyaL1c3htVCjtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  45. T Oshikawa R Baba M Fujita (1996) ArticleTitleApical endocytosis of lectins by the absorptive cells of the suckling rat jejunum in vivo Okajimas Folia Anat Jpn 73 229–246 Occurrence Handle9059057 Occurrence Handle1:CAS:528:DyaK2sXisFyrs78%3D

    PubMed  CAS  Google Scholar 

  46. SF Wissing DO Graney (1968) ArticleTitleMembrane modifications in the apical endocytic complex of ileal epithelia cells J Cell Biol 39 564–579 Occurrence Handle10.1083/jcb.39.3.564

    Article  Google Scholar 

  47. K Ono (1975) ArticleTitleAbsorption of horseradish peroxidase by the small intestinal epithelium in postnatal developing rats Z Mikrosk-Anat Forsch 89 870–883 Occurrence Handle1234392 Occurrence Handle1:STN:280:DyaE2s%2FktVGlug%3D%3D

    PubMed  CAS  Google Scholar 

  48. PC Colony MR Neutra (1985) ArticleTitleMacromolecular transport in the fetal rat intestine Gastroenterology 89 294–306 Occurrence Handle4007421 Occurrence Handle1:STN:280:DyaL2M3jtFyrsA%3D%3D

    PubMed  CAS  Google Scholar 

  49. JM Wilson JA Whitney MR Neutra (1987) ArticleTitleIdentification of an endosomal antigen specific to absorptive cells of suckling rat ileum J Cell Biol 105 691–703 Occurrence Handle3305521 Occurrence Handle10.1083/jcb.105.2.691 Occurrence Handle1:CAS:528:DyaL2sXlslejtrk%3D

    Article  PubMed  CAS  Google Scholar 

  50. S Teichberg RA Wapnir J Moyse F Lifshitz (1992) ArticleTitleDevelopment of the neonatal rat small intestinal barrier to nonspecific macromolecular absorption. II. Role of dietary corticosterone Pediatr Res 32 50–57 Occurrence Handle1635845 Occurrence Handle1:CAS:528:DyaK38XkvVelsLk%3D

    PubMed  CAS  Google Scholar 

  51. WG Forssmann J Metz D Heinrich (1975) ArticleTitleGap junction in the hemotrichorial placenta of the rat J Ultrastruct Res 53 374–381 Occurrence Handle1206781 Occurrence Handle10.1016/S0022-5320(75)80038-4 Occurrence Handle1:STN:280:DyaE28%2Fpslyrtg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  52. G Chaouet JP Kolb TG Wegmann (1983) ArticleTitleThe murine placenta as an immunological barrier between the mother and the fetus Immunol Rev 75 31–60 Occurrence Handle10.1111/j.1600-065X.1983.tb01090.x

    Article  Google Scholar 

  53. K Suzuki M Kobayashi K Kobayashi (1997) ArticleTitleStructural and functional change of blood vessel labyrinth in maturing placenta of mice Trophoblast Res 9 155–164

    Google Scholar 

  54. P Georgiades AC Ferguson-Smith GJ Burton (2002) ArticleTitleComparative developmental anatomy of the murine and human definitive placenta Placenta 23 3–9 Occurrence Handle11869088 Occurrence Handle10.1053/plac.2001.0738 Occurrence Handle1:STN:280:DC%2BD387jt1Kluw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  55. JC Cross D Baczyk N Dobric (2003) ArticleTitleGenes, development and evolution of the placenta Placenta 24 123–130 Occurrence Handle12596737 Occurrence Handle10.1053/plac.2002.0887 Occurrence Handle1:CAS:528:DC%2BD3sXptlOmtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  56. A Aoki WG Forssmann (1978) ArticleTitleStudies on the ultrastructure and permeability of the hemotrichrial placenta Cell Tissue Res 192 409–422 Occurrence Handle699025 Occurrence Handle10.1007/BF00212322 Occurrence Handle1:STN:280:DyaE1M%2FitlSgsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  57. J Metz A Aoki WG Forssmann (1978) ArticleTitleStudies on the ultrastructure and permeability of the hemotrichrial placenta Cell Tissue Res 192 391–407 Occurrence Handle699024 Occurrence Handle10.1007/BF00212321 Occurrence Handle1:STN:280:DyaE1M%2FitlSgsg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  58. TG Wegmann B Singh GA Carison (1979) ArticleTitleAllogeneic placenta in a paternal strain antigen immunoabsorbent J Immunol 122 270–274 Occurrence Handle762418 Occurrence Handle1:CAS:528:DyaE1MXhtF2mur4%3D

    PubMed  CAS  Google Scholar 

  59. K Falth-Magnusson NI Kjellman (1992) ArticleTitleAllergy prevention by maternal elimination diet during late pregnancy: a 5-year follow-up of a randomized study J Allergy Clin Immunol 89 IssueID3 709–713 Occurrence Handle1545092 Occurrence Handle10.1016/0091-6749(92)90378-F Occurrence Handle1:STN:280:DyaK387osFWntA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  60. K Kurosumi Y Kobayashi (1968) ArticleTitleThe fine structure of mammary glands of lactating rats, with special reference to the apocrine secretion Exp Cell Res 50 177–192 Occurrence Handle5689903 Occurrence Handle10.1016/0014-4827(68)90406-0 Occurrence Handle1:STN:280:DyaF1c3ktFeitg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  61. T Kimura (1969) ArticleTitleElectron microscopic study of the mechanism of secretion of milk Nippon Sanka Fujinka Gakkaizassi 21 301–308 Occurrence Handle1:STN:280:DyaF1M3otl2qug%3D%3D

    CAS  Google Scholar 

  62. FBP Wooding (1970) ArticleTitleTheories of milk secretion: evidence from the electron microscopic examination of milk Nature (Lond) 226 762–764 Occurrence Handle10.1038/226762a0 Occurrence Handle1:STN:280:DyaE3c7otVOjtw%3D%3D

    Article  CAS  Google Scholar 

  63. AN Lteif WF Schwenk (1998) ArticleTitleBreast milk Mayo Clin Proc 73 IssueID8 760–763 Occurrence Handle9703302 Occurrence Handle1:STN:280:DyaK1czms1ylsA%3D%3D Occurrence Handle10.4065/73.8.760

    Article  PubMed  CAS  Google Scholar 

  64. P Van de Perre (2003) ArticleTitleTransfer of antibody via mother's milk Vaccine 21 IssueID24 3374–3376 Occurrence Handle12850343 Occurrence Handle10.1016/S0264-410X(03)00336-0 Occurrence Handle1:CAS:528:DC%2BD3sXlt1eisLo%3D

    Article  PubMed  CAS  Google Scholar 

  65. Y Fukushima (1997) ArticleTitleConsumption of cow milk and egg by lactating women and the presence of β-lactoglobulin and ovalbumin in breast milk Am J Clin Nutr 65 30–35 Occurrence Handle8988909 Occurrence Handle1:CAS:528:DyaK2sXjsVymug%3D%3D

    PubMed  CAS  Google Scholar 

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  1. Graduate School of Health and Nutrition Sciences, Nakamura Gakuen University, 5-7-1 Befu, Jonan-ku, Fukuoka, 814-0198, Japan

    Mamoru Fujita, Ryoko Baba, Mariko Shimamoto, Yoshiko Sakuma & Sunao Fujimoto

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  1. Mamoru Fujita
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Correspondence to Mamoru Fujita.

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Fujita, M., Baba, R., Shimamoto, M. et al. Molecular morphology of the digestive tract; macromolecules and food allergens are transferred intact across the intestinal absorptive cells during the neonatal-suckling period. Med Mol Morphol 40, 1–7 (2007). https://doi.org/10.1007/s00795-006-0346-3

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