Variability of ecological executive function in children and adolescents genetically at high risk for schizophrenia: a latent class analysis
Executive impairments have been observed both in patients with schizophrenia and in their unaffected first-degree relatives. Very few studies have investigated neurocognitive subgroups in unaffected first-degree relatives and in healthy participants using data-driven methods. The study included a high-risk group consisting of 100 unaffected young offspring and siblings of patients with schizophrenia and 198 healthy controls, all aged between 9 and 23 years. Executive function, victimization, and emotional and behavioral problems of participants were assessed by a series of self-report scales. Neurocognitive subgroups were investigated using latent class analysis of executive function measures. Four neurocognitive clusters were identified: a good performance cluster, a good self-control cluster, a low self-control cluster, and a severe impairment cluster. Participants in severe impaired executive function cluster reported a significantly higher level of victimization and had more prominent emotional and behavioral problems than the good performance cluster. Neurocognitive differences between high-risk young people and healthy controls were driven by individuals who have severe and global, rather than selective, executive deficits. Our results may provide clues to an explanation of the mechanisms behind executive impairments in young individuals at genetic risk and help to identify new targets for early interventions.
KeywordsSchizophrenia Executive function Neurocognitive disorder Adolescence
Latent class analysis
Statistical Package for Social Sciences
The authors extend their gratitude to all the participants for their time and effort. This study was financially supported by the Natural Science Foundation of Shandong Province (No. ZR2013HM087). All authors had critically reviewed and contributed to manuscript.
Compliance with ethical standards
Conflict of interest
The authors have declared that they have no competing or potential conflicts of interest.
- 2.Greenberg DA (1992) There is more than one way to collect data for linkage analysis: what a study of epilepsy can tell us about linkage strategy for psychiatric disease. Arch Gen Psychiatry 49(9):745–750. https://doi.org/10.1001/archpsyc.1992.01820090073012 CrossRefGoogle Scholar
- 8.Seidman LJ, Giuliano AJ, Smith CW, Stone WS, Glatt SJ, Meyer E, Faraone SV, Tsuang MT, Cornblatt B (2006) Neuropsychological functioning in adolescents and young adults at genetic risk for schizophrenia and affective psychoses: results from the Harvard and hillside adolescent high risk studies. Schizophr Bull 32(3):507–524. https://doi.org/10.1093/schbul/sbj078 CrossRefGoogle Scholar
- 11.Maziade M, Rouleau N, Gingras N, Boutin P, Paradis M-E, Jomphe V, Boutin J, Létourneau K, Gilbert E, Lefebvre A-A (2009) Shared neurocognitive dysfunctions in young offspring at extreme risk for schizophrenia or bipolar disorder in eastern quebec multigenerational families. Schizophr Bull 35(5):919–930CrossRefGoogle Scholar
- 14.Keefe R (2006) Cognitive deficits in patients with schizophrenia: effects and treatment. J Clin Psychiatry 68:8–13Google Scholar
- 16.Organization WH (1992) The ICD-10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines. World Health Organization, GenevaGoogle Scholar
- 17.Guy SC, Gioia GA, Isquith PK (2004) Behavior rating inventory of executive function: self-report version. Psychological Assessment Resources, LutzGoogle Scholar
- 22.Nunnally J, Bernstein I (1994) Psychometric theory, 3rd edn. McGraw-Hill, New YorkGoogle Scholar
- 27.Magidson J, Vermunt J (2002) Latent class models for clustering: a comparison with K-means. Can J Mark Res 20(1):36–43Google Scholar
- 28.Roth RM, Gioia GA (2005) Behavior rating inventory of executive function—adult version. Psychological Assessment Resources, LutzGoogle Scholar
- 31.Keshavan M, Gilbert A, Diwadkar V (2006) Neurodevelopmental theories. The American Psychiatric Publishing textbook of schizophrenia. American Psychiatric Publishing Inc, Washington, DC, pp 69–84Google Scholar
- 36.Zalla T, Joyce C, Szöke A, Schürhoff F, Pillon B, Komano O, Perez-Diaz F, Bellivier F, Alter C, Dubois B, Rouillon F, Houde O, Leboyer M (2004) Executive dysfunctions as potential markers of familial vulnerability to bipolar disorder and schizophrenia. Psychiatry Res 121(3):207–217. https://doi.org/10.1016/S0165-1781(03)00252-X CrossRefGoogle Scholar
- 42.Fett A-KJ, Viechtbauer W, Dominguez M-d-G, Penn DL, van Os J, Krabbendam L (2011) The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neurosci Biobehav Rev 35(3):573–588. https://doi.org/10.1016/j.neubiorev.2010.07.001 CrossRefGoogle Scholar