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Enhanced effect of a novel bioactive glass–ceramic for dental application

Clinical Oral Investigations (2023)Cite this article

Abstract

Objectives

Dental caries is the most common chronic disease in humans, caused by the acid produced by the microflora in the mouth that dissolves the enamel minerals. Bioactive glass (BAG) has been used in various clinical applications due to its unique bioactive properties, such as bone graft substitutes and dental restorative composites. In this study, we introduce a novel bioactive glass–ceramic (NBGC) prepared through a sol–gel process under a water-free condition.

Materials and methods

The anti-demineralization and remineralization effects of NBGC were evaluated by comparing the measurements of bovine enamel surface morphology, surface roughness, surface micro-hardness, enamel elements, and mineral content before and after related treatments with a commercial BAG. The antibacterial effect was characterized by minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC).

Results

Results showed that NBGC had greater acid resistance and remineralization potential compared to commercial BAG. The fast formation of a hydroxy carbonate apatite (HCA) layer suggests efficient bioactivity.

Clinical relevance

In addition to its antibacterial properties, NBGC shows promise as an ingredient in oral care products that can prevent demineralization and restore enamel.

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Data availability

The datasets used or analyzed during the current study are available from the corresponding author upon reasonable request.

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Acknowledgements

We thank Mr. Xiongying Wang for his training on profilometer and EDS.

Funding

This project was supported in part by the 2019 Chongqing Graduate Mentor Team Funding (Grant No. dstd201903).

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Authors and Affiliations

  1. Dencare (Chongqing) Oral Care Co., Ltd, Chongqing, China

    Lin Qiu, Yu Lu, Haide Dong, Huan Zhang, Min Zhang & Quanfu Deng

  2. College of Stomatology, Chongqing Medical University, Chongqing, China

    Lin Qiu & Jinlin Song

  3. Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Chongqing, China

    Jinlin Song

  4. Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, China

    Jinlin Song

Authors
  1. Lin Qiu
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  2. Yu Lu
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  3. Haide Dong
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  4. Huan Zhang
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  5. Min Zhang
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Contributions

Lin Qiu, Yu Lu, Haide Dong, Huan Zhang, Min Zhang, Quanfu Deng, and Jinlin Song conceived and designed the experiments; Lin Qiu performed the demineralization and remineralization experiments, Yu Lu performed the antibacterial experiment and Haide Dong fabricated the NBGC and did the XRD analysis; Lin Qiu analyzed the data together with Quanfu Deng and Jinlin Song; Lin Qiu drafted the paper and Huan Zhang, Min Zhang, Quanfu Deng, and Jinlin Song edited the paper. All authors read and approved the final manuscript.

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Correspondence to Lin Qiu, Quanfu Deng or Jinlin Song.

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Cite this article

Qiu, L., Lu, Y., Dong, H. et al. Enhanced effect of a novel bioactive glass–ceramic for dental application. Clin Oral Invest (2023). https://doi.org/10.1007/s00784-023-04946-y

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Keywords

  • Bioactive
  • Demineralization
  • Remineralization
  • Enamel
  • Dental