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Taste disorder’s management: a systematic review

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Abstract

Background

Taste disorder is a frequent drug-induced or disease-related oral trouble. Various pharmacological, surgical, or physical treatments have previously been proposed for taste function recovery.

Objectives

The aim of the present systematic review was to assess the effects of palliative and curative interventions on taste recovery in light of recent literature.

Materials and methods

In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, a search of the literature published up to June 2019 was conducted using MEDLINE via PubMed, EMBASE, and The US National Institutes of Health Trials Register (PROSPERO registration reference: CRD 42019139315). The methodological quality of the included trials was rated with the “Delphi list For Quality Assessment of Randomized Clinical Trials” and the Newcastle-Ottawa scale.

Results

From the 1842 titles first identified, 28 articles met the inclusion criteria. Interventions included zinc (aspartate, sulfate, gluconate, acetate, picolinate, and Polaprezinc®), esomeprazole, l-thyroxin, bethanechol, oral glutamine, delta-9-tetrahydrocannabinol, alpha-lipoic acid, Ginkgo biloba, artificial saliva, pilocarpine, local anesthesia, and improved oral hygiene. The quality of evidence ranged from poor to high.

Conclusion

Improving oral hygiene may promote taste ability. Zinc may prevent and alleviate taste disorder in patients undergoing head and neck radiotherapy.

Clinical relevance

The systematic review provided evidence about the clinical efficacy of oral procedures, zinc supplementation, and palliative cares in dysgeusic patients. Further research is needed to find effective treatments with low adverse effects.

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Acknowledgments

We would like to thank Patrick Rousseau for proofreading the English.

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Authors and Affiliations

  1. Laboratoire de neurobiologie orofaciale (EA7543), UFR Odontologie, Université de Paris, 5, rue Garancière, 75006, Paris, France

    Adeline Braud & Yves Boucher

  2. Service Odontologie, Hôpital Rothschild, APHP, Paris, France

    Adeline Braud

  3. Service Odontologie, Groupe Hospitalier Pitié Salpêtrière, APHP, Paris, France

    Yves Boucher

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  1. Adeline Braud
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  2. Yves Boucher
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Correspondence to Adeline Braud.

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Braud, A., Boucher, Y. Taste disorder’s management: a systematic review. Clin Oral Invest 24, 1889–1908 (2020). https://doi.org/10.1007/s00784-020-03299-0

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