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Effectiveness of a new dental implant bioactive surface: histological and histomorphometric comparative study in minipigs

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Abstract

Objectives

The objective of this study was to assess, by histomorphometric analysis, the degree of bone apposition on two types of dental implant’s surfaces: a novel implant that combines Al2O3 abrasive particle blasting with thermochemical treatment (ContacTi), compared to a standard surface treatment obtained by sandblasting and acid etching (shot blasting).

Materials and methods

Twelve minipigs were used, placing the studied implants in the maxillae, and divided into three groups according to the time of sacrifice: 2, 4, and 8 weeks after implant placement. Histological and histomorphometric analyses were performed following standardized tissue polymerization, cutting, and staining and examined under optical and high-resolution electron microscope.

Results

For all measurements, the novel surface presented higher levels of osseointegration as compared to the shot blasting surface. Bone to implant contact (BIC) in the maxillae for ContacTi presented values of 49.02, 83.20, and 85.58% at 2, 4, and 8 weeks, respectively, significantly higher compared to the shot blasting surface values of 39.32, 46.53, and 46.20% for the same time points. Bone area density (BAD) presented values of 26.52, 61.21, and 59.50% for ContacTi surface implants and 22.95, 36.26, and 49.50% for the shot blasted surface implants. Signs of osteoconductivity were observed in the ContacTi surfaces at 2 weeks.

Conclusions

The ContacTi surface achieved a faster growth of hard tissues around the implants, when compared to the shot blasting surface, and for all evaluated histomorphometric parameters, the values were higher at all measured time points.

Clinical relevance

ContacTi could be a new surface improving the osseointegration in oral implantology.

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Acknowledgments

The authors would like to acknowledge the Ministry of Science of Spain for funding to this project (MAT2012-30706) as well as Klockner, S.L. for donating the implants used.

Funding

The work was supported by the Spanish government. Ministerio Economía y Competitividad by the research project number MAT2012-30706.

Author information

Authors and Affiliations

  1. Periodontology and Implants at the University of Seville, Seville, Spain

    Mariano Herrero-Climent, Manuel M. Romero Ruizª & Pedro Lázaro Calvo

  2. Department of Dentistry at the University of Seville, Seville, Spain

    José Vicente Ríos Santos

  3. Department of Materials Science and Metallurgical, Engineering, ETSEIB, Universitat Politècnica de Catalunya, Barcelona, Spain

    Roman A. Perez

  4. School of Dentistry, Universitat Internacional de Catalunya, Barcelona, Spain

    Roman A. Perez & Francisco Javier Gil Mur

  5. Facultad de Odontología, Universitat Internacional de Catalunya, Barcelona, Spain

    Francisco Javier Gil Mur

Authors
  1. Mariano Herrero-Climent
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  2. Manuel M. Romero Ruizª
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  3. Pedro Lázaro Calvo
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  4. José Vicente Ríos Santos
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  5. Roman A. Perez
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  6. Francisco Javier Gil Mur
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Corresponding author

Correspondence to Francisco Javier Gil Mur.

Ethics declarations

The present study was carried out in maxillae of 12 six-year-old female minipigs in the Córdoba University’s Servicio Centralizado de Animales de Experimentación located in the Campus de Rabanales and approved by the University of Seville Ethics Experimentation Committee (MED2016-01-324). All requirements and regulations for animal experimentation, according to the Spanish and European Union, were fulfilled.

Conflict of interest

Mariano Herrero-Climent declares that he has no conflict of interest. Manuel María Romero declares that he has no conflict of interest. Pedro Lázaro declares that he has no conflict of interest. José Vicente Rios declares that he has no conflict of interest, and F. Javier Gil Mur declares that he has no conflict of interest.

Ethical approval

This article does not contain any studies with human participants. For the animal study, the study was approved by the University of Seville Ethics Experimentation Committee (MED2016-01-324).

Informed consent

For this type of study, formal consent is not required.

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Herrero-Climent, M., Romero Ruizª, M.M., Calvo, P.L. et al. Effectiveness of a new dental implant bioactive surface: histological and histomorphometric comparative study in minipigs. Clin Oral Invest 22, 1423–1432 (2018). https://doi.org/10.1007/s00784-017-2223-y

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  • DOI: https://doi.org/10.1007/s00784-017-2223-y

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