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Prognostic implication of NOTCH1 in early stage oral squamous cell cancer with occult metastases

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Abstract

Objective

The objective of this study was to explore the prognostic value of cancer stem cell markers, namely CD133, NANOG, and NOTCH1, in early stage oral squamous cell carcinoma (OSCC).

Materials and methods

One hundred forty-four patients with early stage (cT1T2N0) OSCC were identified from a pre-existing database of patients with oral cancer. We examined the impact of the immunohistochemical expression of CD133, NANOG, and NOTCH1 in OSCC. Overall survival (OS) curves were calculated using the Kaplan–Meier method. Predictors of outcome were identified using multivariate analysis.

Results

We found that CD133, NANOG, and NOTCH1 were significantly associated with lymph node metastasis, and NOTCH1 was also significantly associated with depth of invasion and locoregional recurrence.

Conclusions

NOTCH1 was identified as an independent prognostic factor for OS.

Clinical relevance

NOTCH1 might prove to be a useful indicator for high-risk patients with occult metastases from early stage OSCC.

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Funding

This work was supported by grants from the Doctoral Program Foundation of First Affiliated Hospital of Harbin Medical University in China (no. 2016B015).

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Authors and Affiliations

  1. Department of Oral Pathology, Hospital of Stomatology, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, People’s Republic of China

    Shan Wang & Eryang Zhao

  2. Department of Anatomy, Basic Medical Science College, Harbin Medical University, Harbin, 150081, People’s Republic of China

    Haixia Fan

  3. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, People’s Republic of China

    Jiankai Xu

Authors
  1. Shan Wang
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  2. Haixia Fan
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  3. Jiankai Xu
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  4. Eryang Zhao
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Corresponding author

Correspondence to Eryang Zhao.

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Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the First Affiliated Hospitals of Harbin Medical University Institutional Research Board and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Wang, S., Fan, H., Xu, J. et al. Prognostic implication of NOTCH1 in early stage oral squamous cell cancer with occult metastases. Clin Oral Invest 22, 1131–1138 (2018). https://doi.org/10.1007/s00784-017-2197-9

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  • DOI: https://doi.org/10.1007/s00784-017-2197-9

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