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Influence of voluntary control of masticatory side and rhythm on cerebral hemodynamics

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Abstract

The aim of this study was to investigate the influence on cerebral hemodynamics of voluntary control of masticatory side and rhythm during gum chewing. Blood flow velocity in the middle cerebral artery was measured using transcranial Doppler ultrasonography to evaluate cerebral circulation in healthy volunteers. Heart rate and masseter muscle activity were recorded simultaneously. Volunteers performed three tasks: (1) free gum chewing, (2) gum chewing in which mastication was limited to the right side, and (3) gum chewing in which mastication was limited to the right side and rhythm was set at 1.0 Hz. Changes in cerebral circulation during pre-task, on-task, and post-task periods were analyzed using random effects model, and differences in cerebral circulation and muscle activity between tasks were analyzed using the Friedman test. In all tasks, on-task cerebral circulation was greater than pre-task. Muscle activity and masticatory rhythm varied between tasks, whereas the rate of increase in cerebral circulation did not differ significantly among tasks. These results suggest that cerebral circulation is activated during gum chewing, irrespective of voluntary control of masticatory side and rhythm.

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Acknowledgements

The authors gratefully acknowledge the encouragement of the Late Honorary Professor Shinichiro Watanabe of the School of Medicine at Osaka University. We also wish to thank Dr. Masayuki Ohta of the Graduate School of Dentistry at Osaka University and Dr. Yoshihisa Tachibana of the National Institute for Physiological Sciences for their valuable advice. Finally, we are grateful to Dr. Yasuko Hashimoto, Director of Hashimoto Hospital, for financial support of this study. This study was supported by a Grant from Ministry of Education, Science and Culture of Japan (Grant No. 19791433) and Global COE Program “in silico medicine” at Osaka University.

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Authors and Affiliations

  1. Division of Oromaxillofacial Regeneration, Osaka University Graduate School of Dentistry, 1-8 Yamada-oka, Suita, Osaka, Japan

    Yoko Hasegawa, Takahiro Ono, Joe Sakagami, Kazuhiro Hori & Yoshinobu Maeda

  2. Department of Biomedical Statistics, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, Japan

    Toshimitsu Hamasaki

  3. Center for Advanced Science and Innovation, Osaka University, 2-1 Yamada-oka, Suita, Osaka, Japan

    Takashi Nokubi

Authors
  1. Yoko Hasegawa
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  2. Takahiro Ono
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  3. Joe Sakagami
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  4. Kazuhiro Hori
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  5. Yoshinobu Maeda
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  6. Toshimitsu Hamasaki
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  7. Takashi Nokubi
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Correspondence to Takahiro Ono.

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Hasegawa, Y., Ono, T., Sakagami, J. et al. Influence of voluntary control of masticatory side and rhythm on cerebral hemodynamics. Clin Oral Invest 15, 113–118 (2011). https://doi.org/10.1007/s00784-009-0338-5

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  • DOI: https://doi.org/10.1007/s00784-009-0338-5

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