Skip to main content
SpringerLink
Log in

A metallo-biopolymer conjugate of elastin-like polypeptide: photoluminescence enhancement in the coacervate microenvironment

  • Original Paper
  • Published:
JBIC Journal of Biological Inorganic Chemistry Aims and scope Submit manuscript

Abstract

An optically active metallo-polymer assembly is demonstrated via conjugation of a genetically engineered elastin-like polypeptide (ELP) and a ruthenium(II) polypyridyl complex. By taking advantage of the phase transition of ELPs in water, photophysical properties of the resultant conjugate are investigated for both phases, below and above the critical transition temperature. Upon coacervation, the luminescence of the metallo-ELP is greatly enhanced as a consequence of local effects on the metal–ligand luminophore. These findings open a possibility to harness the temperature control of stimuli-responsive properties of biopolymers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Wei W, Petrone L, Tan Y, Cai H, Israelachvili JN, Miserez A, Waite JH (2016) Adv Funct Mater 26:3496–3507

    Article  CAS  Google Scholar 

  2. Tan Y, Hoon S, Guerette PA, Wei W, Ghadban A, Hao C, Miserez A, Waite JH (2015) Nat Chem Biol 11:488–495

    Article  CAS  Google Scholar 

  3. Yeo GC, Keeley FW, Weiss AS (2011) Adv Colloid Interf Sci 167:94–103

    Article  CAS  Google Scholar 

  4. Strom AR, Emelyanov AV, Mir M, Fyodorov DV, Darzacq X, Karpen GH (2017) Nature 547:241

    Article  CAS  Google Scholar 

  5. Brangwynne CP, Eckmann CR, Courson DS, Rybarska A, Hoege C, Gharakhani J, Jülicher F, Hyman AA (2009) Science 324:1729–1732

    Article  CAS  Google Scholar 

  6. Victor R, Woisel P, Hoogenboom R (2016) Mater Today 19:44–55

    Article  Google Scholar 

  7. Sista P, Ghosh K, Martinez JS, Rocha RC (2014) Polym Rev 54:627–676

    Article  CAS  Google Scholar 

  8. Gil ES, Hudson SM (2004) Prog Polym Sci 29:1173–1222

    Article  CAS  Google Scholar 

  9. Chilkoti A, Christensen T, MacKay JA (2006) Curr Opin Chem Biol 10:652–657

    Article  CAS  Google Scholar 

  10. Stuart MAC, Huck WTS, Genzer J, Müller M, Ober C, Stamm M, Sukhorukov GB, Szleifer I, Tsukruk VV, Urban M (2010) Nat Mater 9:101–113

    Article  Google Scholar 

  11. Simon JR, Carroll NJ, Rubinstein M, Chilkoti A, López GP (2017) Nat Chem 9:509

    Article  CAS  Google Scholar 

  12. Meyer DE, Chilkoti A (2002) Biomacromol 3:357–367

    Article  CAS  Google Scholar 

  13. Gonzalez MA, Simon JR, Ghoorchian A, Scholl Z, Lin S, Rubinstein M, Marszalek P, Chilkoti A, López GP, Zhao X (2017) Adv Mater. https://doi.org/10.1002/adma.201604743

    Article  PubMed  Google Scholar 

  14. Urry DW, Trapane TL, Prasad KU (1985) Biopolymers 24:2345–2356

    Article  CAS  Google Scholar 

  15. MacEwan SR, Chilkoti A (2010) Pept Sci 94:60–77

    Article  CAS  Google Scholar 

  16. Bellingham CM, Lillie MA, Gosline JM, Wright GM, Starcher BC, Bailey AJ, Woodhouse KA, Keeley FW (2003) Biopolymers 70:445–455

    Article  CAS  Google Scholar 

  17. Almine JF, Bax DV, Mithieux SM, Nivison-Smith L, Rnjak J, Waterhouse A, Wise SG, Weiss AS (2010) Chem Soc Rev 39:3371–3379

    Article  CAS  Google Scholar 

  18. Floss DM, Schallau K, Rose-John S, Conrad U, Scheller J (2010) Trends Biotechnol 28:37–45

    Article  CAS  Google Scholar 

  19. Demas JN, DeGraff BA (2001) Coord Chem Rev 211:317–351

    Article  CAS  Google Scholar 

  20. Gill MR, Garcia-Lara J, Foster SJ, Smythe C, Battaglia G, Thomas JA (2009) Nat Chem 1:662–667

    Article  CAS  Google Scholar 

  21. Campagna S, Puntoriero F, Nastasi F, Bergamini G, Balzani V (2007) Photochemistry and photophysics of coordination compounds. Springer, Berlin, pp 117–214

    Book  Google Scholar 

  22. Chen P, Meyer TJ (1998) Chem Rev 98:1439–1478

    Article  CAS  Google Scholar 

  23. Ghosh K, Balog ERM, Kahn JL, Shepherd DP, Martinez JS, Rocha RC (2015) Macromol Chem Phys 216:1856–1861

    Article  CAS  Google Scholar 

  24. Ghosh K, Balog ERM, Sista P, Williams DJ, Kelly D, Martinez JS, Rocha RC (2014) APL Mat 2:021101

    Article  Google Scholar 

  25. Ellis CD, Margerum LD, Murray RW, Meyer TJ (1983) Inorg Chem 22:1283–1291

    Article  CAS  Google Scholar 

  26. Juris A, Balzani V, Barigelletti F, Campagna S, Belser PL, Von Zelewsky A (1988) Coord Chem Rev 84:85–277

    Article  CAS  Google Scholar 

  27. Dixon EN, Snow MZ, Bon JL, Whitehurst AM, DeGraff BA, Trindle C, Demas JN (2012) Inorg Chem 51:3355–3365

    Article  CAS  Google Scholar 

  28. Ji S, Guo H, Yuan X, Li X, Ding H, Gao P, Zhao C, Wu W, Wu W, Zhao J (2010) Org Lett 12:2876–2879

    Article  CAS  Google Scholar 

  29. Lees AJ (1995) Comments Inorg Chem 17:319–346

    Article  CAS  Google Scholar 

  30. Krishna OD, Kiick KL (2010) Biopolymers 94:32–48

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors acknowledge financial support, including a Director’s postdoctoral fellowship (K.G.), by the Laboratory Directed Research and Development (LDRD) program. K.E. acknowledges the financial support from the U.S. Department of Energy, Office of Science, and Office of Workforce Development for Teachers and Scientists (WDTS) under the Science Undergraduate Laboratory Internships (SULI) program. This work was partly performed at the Center for Integrated Nanotechnologies, an Office of Science User Facility operated for the U.S. Department of Energy (DOE) Office of Science. Los Alamos National Laboratory, an affirmative action equal opportunity employer, is operated by Los Alamos National Security, LLC, for the National Nuclear Security Administration of the U.S. Department of Energy under contract DE-AC52-06NA25396.

Author information

Authors and Affiliations

  1. Los Alamos National Laboratory, Center for Integrated Nanotechnologies, Materials Physics and Applications Division (MPA-CINT), Los Alamos, NM, 87545, USA

    Koushik Ghosh, Katherine C. Elbert, Eva Rose M. Balog, Jennifer S. Martinez & Reginaldo C. Rocha

  2. Los Alamos National Laboratory, Institute for Materials Science (IMS), Los Alamos, NM, 87545, USA

    Jennifer S. Martinez

Authors
  1. Koushik Ghosh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Katherine C. Elbert
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Eva Rose M. Balog
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jennifer S. Martinez
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Reginaldo C. Rocha
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Jennifer S. Martinez or Reginaldo C. Rocha.

Additional information

This invited paper is for the special issue in celebration of Alison Butler as recipient of the 2018 ACS Alfred Bader Award in Bioorganic or Bioinorganic Chemistry.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ghosh, K., Elbert, K.C., Balog, E.R.M. et al. A metallo-biopolymer conjugate of elastin-like polypeptide: photoluminescence enhancement in the coacervate microenvironment. J Biol Inorg Chem 23, 1153–1157 (2018). https://doi.org/10.1007/s00775-018-1580-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00775-018-1580-6

Keywords

Search

Navigation