Zusammenfassung
Fortschritte der chirurgischen und systemischen Therapien des Ovarialkarzinoms haben die Überlebenszeiten von Patientinnen verlängert und den Fokus auf deren Lebensqualität (LQ) erhöht. Die Berücksichtigung von Patient Reported Outcomes (PROs) als primäre oder sekundäre Endpunkte in klinischen Ovarialkarzinomstudien ist in den letzten Jahren deutlich angestiegen. Für die Messung von PROs stehen standardisierte Instrumente zur Verfügung, die speziell für Patientinnen mit Ovarialkarzinom entwickelt wurden. PRO-Instrumente sind mittels internetbasierter Erfassungsmethoden als ePROs verfügbar und weniger zeit- und kostenintensiv. Klinische Studienergebnisse mit PRO-Endpunkten haben in der Behandlung des Ovarialkarzinoms zur Veränderung des international anerkannten Therapiestandards geführt. Auf Grundlage der Daten wurden Carboplatin plus Paclitaxel weltweit als neuer Standard der Primärtherapie des fortgeschrittenen Ovarialkarzinoms festgelegt. Eine weitere Individualisierung der Therapie unter Berücksichtigung der LQ von Patientinnen konnte in der späten Rezidivsituation des Ovarialkarzinoms ermöglicht werden. Neben klinischen Studien finden PROs zunehmend auch in der klinischen Routine Eingang. Die Mehrheit onkologischer Patienten befürwortet die routinemäßige Erfassung der LQ. PRO-Daten geben wichtige Information über die subjektive Auswirkung der Erkrankung und der Therapie auf die LQ der Patientinnen, können für gemeinsame Therapieentscheidungen herangezogen werden und Behandlungsoptionen an die Bedürfnisse der Patientinnen anpassen.
Abstract
Progress in surgical and systemic treatment for ovarian cancer has prolonged survival times of patients and changed the focus towards patients’ quality of life (QoL). The inclusion of patient-reported outcomes (PROs) as primary or secondary outcomes in clinical ovarian cancer studies has significantly increased in recent years. There are standardized instruments developed specifically for ovarian cancer patients to measure PROs. Web-based ePRO questionnaires are also available, saving time and expense. Results from clinical studies with PROs as the focus have led to a change in the international standardized therapy for ovarian cancer. Based on these data carboplatin/paclitaxel has become the new worldwide standard primary therapy for advanced ovarian cancer. A further individualization of treatment taking QoL of patients into account, could be made possible for late relapsed ovarian cancer. In addition to clinical trials, PROs are increasingly being used in routine clinical practice. The majority of cancer patients support the routine assessment of QoL. The PRO data provide important information about the subjective effect of the disease and the treatment on the QoL of patients. This information can then be used for clinical decision-making to select the best treatment option based on the needs of the patients.
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E. Greimel, V. Bjelic-Radisic, E. Nagele, B. Bliem und K. Tamussino geben an, dass kein Interessenkonflikt besteht.
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Greimel, E., Bjelic-Radisic, V., Nagele, E. et al. Lebensqualität bei Patientinnen mit Ovarialkarzinom. Onkologe 25, 151–156 (2019). https://doi.org/10.1007/s00761-018-0484-y
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DOI: https://doi.org/10.1007/s00761-018-0484-y