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Pathologie des invasiven Mammakarzinoms

The pathology of invasive breast carcinoma

  • Leitthema
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Zusammenfassung

Das invasive Mammakarzinom ist der häufigste maligne Tumor der Frau. Für die lokale Behandlung und für die Abschätzung von Prognose und Prädiktion sind die vom Pathologen erhobenen Befunde von herausragender Bedeutung. Darüber hinaus haben in den letzten Jahren neue zellbiologische und molekulare Erkenntnisse zu einem besseren Verständnis der Entwicklung und biologischen Vielfalt von Mammakarzinomen geführt.

Im ersten Teil der Ausführungen wird versucht, die Entwicklung der Mammakarzinome auf der Basis zellbiologischer und molekularer Grundlagen zu erklären und den Kontext zu den benignen proliferativen Erkrankungen und den In-situ-Neoplasien herzustellen. Im zweiten Teil werden einige wichtige Subtypen des Mammakarzinoms dargestellt. Der dritte Teil beschäftigt sich mit den heute anerkannten prognostischen und prädiktiven Faktoren, die ganz überwiegend vom Pathologen im Rahmen seiner Diagnostik erfasst werden müssen.

Abstract

Invasive breast carcinoma is the most common malignant tumour in women. The pathologist’s diagnosis is of pivotal importance for local therapy as well as for establishing the prognostic and predictive factors of such a malignancy. Moreover, new cell biological and molecular findings have led to a better understanding of the numerous variants of breast carcinoma.

The first part of our review is an attempt to explain the development of breast carcinomas against the background of cell biological and molecular principles and to place this malignancy into the context of benign proliferative breast disease and in situ neoplasia. The second part gives an account of some important subtypes of breast carcinoma, and the third part is dedicated to the currently accepted prognostic and predictive factors, the majority of which have to be assessed by the pathologist within the framework of his or her diagnostics.

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  1. Gerhard Domagk-Institut für Pathologie, Domagk-Straße 17, 48159, Münster, Deutschland

    W. Böcker & T. Decker

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  1. W. Böcker
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Böcker, W., Decker, T. Pathologie des invasiven Mammakarzinoms. Onkologe 14, 443–453 (2008). https://doi.org/10.1007/s00761-008-1352-y

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