The association of serum C-reactive protein with the occurrence and course of postpartum depression
CRP has been positively correlated with depressive symptomatology but this has received less study in postpartum depression (PPD). In this secondary analysis of a trial of PPD treatment, depressive symptoms (Structured Interview Guide for the Hamilton Depression Rating Scale—Atypical Depression Symptoms (SIGH-ADS29)) and serum CRP levels were assessed and associations between CRP and SIGH-ADS29 scores evaluated. The associations between baseline log CRP and depression response and remission were also assessed. Of the 35 women included, neither baseline log CRP nor exit log CRP was significantly associated with SIGH-ADS29 score. Baseline CRP was not associated with response or remission. In this sample of women with PPD, CRP was not associated with depressive symptoms nor response to treatment.
KeywordsPostpartum depression Inflammation C-reactive protein CRP
This work was supported by the National Institutes of Health awarded to ESM (5K12HD050121-09).
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent was obtained from all individual participants included in the study.
- Chang JP, Guu TW, Chen YC, Galecki P, Walczewska A, Su KP (2017) BanI polymorphism of cytosolic phospholipase A2 gene and somatic symptoms in medication-free acute depressed patients. Prostaglandins Leukot Essent Fatty Acids. https://doi.org/10.1016/j.plefa.2017.01.001
- Jha MK, Minhajuddin A, Gadad BS, Greer T, Grannemann B, Soyombo A, Mayes TL, Rush AJ, Trivedi MH (2017) Can C-reactive protein inform antidepressant medication selection in depressed outpatients? Findings from the CO-MED trial. Psychoneuroendocrinology 78:105–113. https://doi.org/10.1016/j.psyneuen.2017.01.023 CrossRefPubMedGoogle Scholar
- Pendeloski KP, Ono E, Torloni MR, Mattar R, Daher S (2017) Maternal obesity and inflammatory mediators: a controversial association. https://doi.org/10.1111/aji.12674
- Wisner KL, Sit DKY, Moses-Kolko EL, Driscoll KE, Prairie BA, Stika CS, Eng HF, Dills JL, Luther JF, Wisniewski SR (2015) Transdermal estradiol treatment for postpartum depression: a pilot, randomized trial. J Clin Psychopharmacol 35:389–395. https://doi.org/10.1097/jcp.0000000000000351 PubMedPubMedCentralGoogle Scholar