Symptoms of anxiety and depression during pregnancy and their association with low birth weight in Chinese women: a nested case control study
This study is a nested case control study from a population-based cohort study conducted in Wuhan, China. The aim is to estimate the association between symptoms of depression during pregnancy (DDP), anxiety during pregnancy(ADP), and depression with anxiety during pregnancy (DADP) and low birth weight (LBW) and to examine the extent to which preterm birth (PTB) moderates these associations. Logistic regression analyses were used to model associations between DDP, ADP, and DADP and LBW. Models were stratified by the presence or absence of PTB to examine moderating effects. From the cohort study, 2853 had a LBW baby (cases); 5457 pregnant women served as controls. Women with DDP or ADP only were not at higher risk of having a LBW baby, but DADP was associated with increased risk of LBW (crude OR 1.41, 95% CI 1.17–1.70; adjusted OR 1.29, 95% CI 1.07–1.57), and the significant association was particularly evident between DADP and LBW in PTB, but not in full-term births. Our data suggests that DADP is related to an increased risk of LBW and that this association is most present in PTBs.
KeywordsLow birth weight Depression during pregnancy Anxiety during pregnancy Preterm birth
We appreciated the hard work of all the maternal and child health care staff in the seven District Maternal and Child Health Care Hospitals and 113 Community Health Service Centers in inner city, Wuhan, China.
Compliance with ethical standards
The study was approved by the institutional review board for human studies at our Saint Louis University, USA, and the Ethical Committee of WMHCWC. The study protocol complied with the principles outlined in the Declaration of Helsinki. All participants provided written informed consent prior to beginning data collection.
Conflict of interest
This study was sponsored by the HEI, US (4791-RFA09-2/10-5), and the Province Natural Science Foundation, Hubei Province, China (2010CDB08803). The authors declare that they have no competing interests.
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