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Archives of Women's Mental Health

, Volume 20, Issue 2, pp 283–290 | Cite as

Symptoms of anxiety and depression during pregnancy and their association with low birth weight in Chinese women: a nested case control study

  • Shaoping Yang
  • Rong Yang
  • Shengwen Liang
  • Jing Wang
  • Nancy L. Weaver
  • Ke Hu
  • Ronghua Hu
  • Edwin Trevathan
  • Zhen Huang
  • Yiming Zhang
  • Ting Yin
  • Jen Jen Chang
  • Jinzhu zhao
  • Longjiao Shen
  • Guanghui Dong
  • Tongzhang Zheng
  • Shunqing Xu
  • Zhengmin Qian
  • Bin Zhang
Original Article

Abstract

This study is a nested case control study from a population-based cohort study conducted in Wuhan, China. The aim is to estimate the association between symptoms of depression during pregnancy (DDP), anxiety during pregnancy(ADP), and depression with anxiety during pregnancy (DADP) and low birth weight (LBW) and to examine the extent to which preterm birth (PTB) moderates these associations. Logistic regression analyses were used to model associations between DDP, ADP, and DADP and LBW. Models were stratified by the presence or absence of PTB to examine moderating effects. From the cohort study, 2853 had a LBW baby (cases); 5457 pregnant women served as controls. Women with DDP or ADP only were not at higher risk of having a LBW baby, but DADP was associated with increased risk of LBW (crude OR 1.41, 95% CI 1.17–1.70; adjusted OR 1.29, 95% CI 1.07–1.57), and the significant association was particularly evident between DADP and LBW in PTB, but not in full-term births. Our data suggests that DADP is related to an increased risk of LBW and that this association is most present in PTBs.

Keywords

Low birth weight Depression during pregnancy Anxiety during pregnancy Preterm birth 

Notes

Acknowledgments

We appreciated the hard work of all the maternal and child health care staff in the seven District Maternal and Child Health Care Hospitals and 113 Community Health Service Centers in inner city, Wuhan, China.

Compliance with ethical standards

The study was approved by the institutional review board for human studies at our Saint Louis University, USA, and the Ethical Committee of WMHCWC. The study protocol complied with the principles outlined in the Declaration of Helsinki. All participants provided written informed consent prior to beginning data collection.

Conflict of interest

This study was sponsored by the HEI, US (4791-RFA09-2/10-5), and the Province Natural Science Foundation, Hubei Province, China (2010CDB08803). The authors declare that they have no competing interests.

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Copyright information

© Springer-Verlag Wien 2016

Authors and Affiliations

  • Shaoping Yang
    • 1
  • Rong Yang
    • 1
  • Shengwen Liang
    • 2
  • Jing Wang
    • 3
  • Nancy L. Weaver
    • 3
  • Ke Hu
    • 2
  • Ronghua Hu
    • 1
  • Edwin Trevathan
    • 3
  • Zhen Huang
    • 2
  • Yiming Zhang
    • 1
  • Ting Yin
    • 2
  • Jen Jen Chang
    • 3
  • Jinzhu zhao
    • 1
  • Longjiao Shen
    • 2
  • Guanghui Dong
    • 4
  • Tongzhang Zheng
    • 5
  • Shunqing Xu
    • 6
  • Zhengmin Qian
    • 3
  • Bin Zhang
    • 1
  1. 1.Wuhan Medical and Health Center for Women and ChildrenWuhanChina
  2. 2.Wuhan Environmental Monitoring CenterWuhanChina
  3. 3.College for Public Health and Social JusticeSaint Louis UniversitySaint LouisUSA
  4. 4.School of Public HealthSun Yat-Sen UniversityGuangzhouChina
  5. 5.School of Public HealthBrown UniversityProvidenceUSA
  6. 6.Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

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