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Amino Acids

, Volume 18, Issue 2, pp 177–191 | Cite as

Synthesis and antibacterial activity of some new non-proteinogenic amino acids containing thiazole residues

  • M. Stanchev
  • T. Pajpanova
  • E. Golovinsky

Summary.

Some new thioamides and thiazoles have been synthesized using canavanine, S-cysteine, homo-S-cysteinesulfonamides and their N-ω-aminoethylated derivatives as adducts in order to investigate the structure-antimicrobial activity relationships. The compounds showed substantial antibacterial activity in vitro against various gram-positive (Staphylococcus aureus, Bacillus cereus etc.) and gram-negative (Escherichia coli, Proteus vulgaris etc.) bacteria. These findings indicate that the presence of the thiazole residue is an essential factor for the antibacterial effect.

Keywords: Heterocyclic amino acids – Peptide mimetics – Thiazole – Antimicrobial activity – Canavanine – S-Cysteine- and homo-S-Cysteinesulfonamides – Alkaline protease 

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Copyright information

© Springer-Verlag Wien 2000

Authors and Affiliations

  • M. Stanchev
    • 1
  • T. Pajpanova
    • 1
  • E. Golovinsky
    • 1
  1. 1.Institute of Molecular Biology, Bulgarian Academy of Sciences, Sofia, BulgariaBG

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