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Amino Acids

, Volume 18, Issue 2, pp 139–146 | Cite as

Homocysteine, vitamins B6, B12, folate, and risk of coronary artery disease in patients undergoing diagnostic coronary angiography

  • I. Abdelmouttaleb
  • N. Danchin
  • I. Aimone-Gastin
  • F. Namour
  • M. Angioi
  • M. -A. Gelot
  • N. Bennani
  • D. Lambert
  • C. Jeandel
  • J. L. Guéant

Summary.

Homocysteine and vitamins B were correlated with coronary artery disease in patients undergoing diagnostic coronary angiography. 160 patients having ≧1 stenosis (G1), 55 patients having normal coronary arteries (G2) and 171 healthy volunteers (G3) were prospectively recruited.

Homocysteine levels were significantly higher in patients, particulary in those with normal coronary angiograms, than in healthy subjects (13.8 ± 6.3 μmol/L in G1 (p < 0.0001) and 15.2 ± 8.8 μmol/L in G2 (p < 0.0001) versus 10.1 ± 3.1 μmol/L in G3). Homocysteine levels were not related to the extent of coronary artery disease. In patients with normal angiogram, vitamin B12 and folate levels were significantly higher compared with the other groups (p < 0.05 and p < 0.001, respectively) showing that vitamin B deficiency was not involved in the hyperhomocysteinemia.

In conclusion, homocysteine and vitamins B levels do not contribute to discriminate for the presence of coronary artery disease in patients undergoing diagnostic coronary angiography. Homocysteine levels, however, were higher in patients referred for coronary angiography than in healthy controls.

Keywords: Amino acids – Homocysteine – Vitamin B12 – Vitamin B6 – Folates – Coronary artery disease 

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Copyright information

© Springer-Verlag Wien 2000

Authors and Affiliations

  • I. Abdelmouttaleb
    • 1
  • N. Danchin
    • 2
  • I. Aimone-Gastin
    • 1
  • F. Namour
    • 1
  • M. Angioi
    • 2
  • M. -A. Gelot
    • 5
  • N. Bennani
    • 1
  • D. Lambert
    • 4
  • C. Jeandel
    • 3
  • J. L. Guéant
    • 1
  1. 1.Laboratory of Cellular and Molecular Pathology in Nutrition (EP-CNRS 616), University Hospital Center of Nancy, Vandoeuvre les Nancy, FranceFR
  2. 2.Department of Cardiology, University Hospital Center of Nancy, Vandoeuvre les Nancy, FranceFR
  3. 3.Department of Internal Medicine, University Hospital Center of Nancy, Vandoeuvre les Nancy, FranceFR
  4. 4.INSERM U308, University Hospital Center of Nancy, Vandoeuvre les Nancy, FranceFR
  5. 5.Laboratory of Biochemistry, University Hospital Center of Nancy, Vandoeuvre les Nancy, FranceFR

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