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Novel DNA/RNA-targeting amino acid beacon for the versatile incorporation at any position within the peptide backbone

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Abstract

One-pot tandem synthesis was for the first time applied to attach fluorophore to the amino acid side chain, yielding amino acid ready for peptide coupling at the N-terminus, and also upon activation at the C-terminus. Two new compounds differing only in fluorophore-linker length showed exceptional fluorimetric and CD recognition between DS-RNA and DS-DNA, thus being promising beacons for versatile peptide incorporation.

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Acknowledgements

This work has been supported by the Croatian Science Foundation project 1477. Special thanks go to Prof. Todor Deligeorgiev and Dr. Atanas Kurutos for fruitful discussions and advice.

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Authors and Affiliations

  1. Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000, Zagreb, Croatia

    Tamara Šmidlehner & Ivo Piantanida

Authors
  1. Tamara Šmidlehner
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  2. Ivo Piantanida
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Correspondence to Ivo Piantanida.

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The authors declare that there are no conflicts of interest.

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This article does not contain any studies with human participants or animals performed by any of the authors.

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Responsible Editor: Dr. Fernando Albericio.

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Šmidlehner, T., Piantanida, I. Novel DNA/RNA-targeting amino acid beacon for the versatile incorporation at any position within the peptide backbone. Amino Acids 49, 1381–1388 (2017). https://doi.org/10.1007/s00726-017-2438-x

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  • DOI: https://doi.org/10.1007/s00726-017-2438-x

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