Abstract
The link between eukaryotic translation elongation factor 1A (eEF1A) and signal transduction pathways through the regulatory mechanism of phosphorylation has never been considered. In this review, we focus on the different kinases that recognize the Ser and Thr residues of the eEF1A1 and eEF1A2 isoforms and regulate their involvement in different cellular processes like cell survival and apoptosis. In this context, polyamines seem to play a role in the regulation of the translation elongation process by modulating the Ser/Thr kinases involved in the phosphorylation of translation elongation factors.
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Abbreviations
- CDK:
-
Cyclin-dependent kinase
- DAG:
-
Diacylglycerol
- GEF:
-
Guanine-nucleotide exchange factor
- eEF1A:
-
Eukaryotic elongation factor 1A
- eEF1B:
-
Eukaryotic guanine-nucleotide exchange factor
- ERK:
-
Extracellular signal-regulated kinase
- ERM:
-
Ezrin, radixin, moesin proteins
- GEF:
-
Guanine-nucleotide exchange factor
- HCC:
-
Human hepatocellular carcinoma
- HSV:
-
Herpes simplex virus
- MAPK:
-
Mitogen-activated protein kinase
- mTOR:
-
Mammalian target of rapamycin
- BDNF:
-
Brain-derived neurotrophic factor
- INFα:
-
Interferon α
- JNK-1:
-
c-Jun N-terminal kinase
- PMA:
-
Phorbol 12-myristate 13-acetate
- PKC:
-
Protein kinase C
- TGF-β:
-
Transforming growth factor β
- MAPK:
-
Mitogen-activated protein kinase
- MDM4:
-
Murine double minute 4
- MBS:
-
Myosin-binding subunit
- MEK:
-
MAPK/ERK kinase
- MLC:
-
Myosin light chain
- MDM4:
-
Mouse double minute homolog 4
- MS:
-
Mass spectrometry
- mTOR:
-
Mammalian target of rapamycin
- Myc:
-
Myelocytomatosis oncogene cellular homologe
- IF5A:
-
Eukaryotic initiation factor 5A
- EGFR:
-
Epidermal growth factor receptor
- APAO:
-
Acetyl polyamine oxidase
- PASKIN:
-
PAS Kinase
- PI3K/AKT:
-
Phosphoinositide-3-kinase and protein kinase B
- PtdIns:
-
Phosphatidylinositol 4,5-Bisphosphate
- PtdSer:
-
Phosphatidylserine
- RAS:
-
Reticular-activating system
- SMO:
-
Spermine oxidase
- SSAT:
-
Spermidine/spermine N1-acetyltransferase
- TbR-I:
-
TGF-β receptor
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Acknowledgments
This work was supported by funds from Programmi di Ricerca Scientifica di Rilevante Interesse Nazionale (2012CK5RPF_004), PON Ricerca e Competitività 2007–2013 (PON01_02782) to PA, and University of Rome Sapienza, MIUR (Ministero dell’Istruzione, dell’Università e della Ricerca) and Regione Lazio (Prot. FILAS-RU-2014-1020) to EA. We also acknowledge the support of POR Campania FSE 2007–2013, Project CRÈME.
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Migliaccio, N., Martucci, N.M., Ruggiero, I. et al. Ser/Thr kinases and polyamines in the regulation of non-canonical functions of elongation factor 1A. Amino Acids 48, 2339–2352 (2016). https://doi.org/10.1007/s00726-016-2311-3
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DOI: https://doi.org/10.1007/s00726-016-2311-3