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Advances in the synthesis of α-quaternary α-ethynyl α-amino acids

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Abstract

α-Quaternary α-ethynyl α-amino acids are an important class of non-proteinogenic amino acids that play an important role in the development of peptides and peptidomimetics as therapeutic agents and in the inhibition of enzyme activities. This review provides an overview of the literature concerning synthesis and applications of α-quaternary α-ethynyl α-amino acids covering the period from 1977 to 2015.

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  1. Univ. Nimes, EA7352 CHROME, Rue du Dr G. Salan, 30021, Nîmes Cedex 1, France

    Thibaut Boibessot, David Bénimélis, Patrick Meffre & Zohra Benfodda

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  1. Thibaut Boibessot
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  2. David Bénimélis
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  3. Patrick Meffre
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  4. Zohra Benfodda
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Correspondence to Zohra Benfodda.

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We gratefully thank the French “ministère de l’éducation nationale, de l’enseignement supérieur et de la recherche” and the University of Nîmes for their financial support.

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The manuscript does not contain clinical studies or patient data.

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Handling Editor: J. D. Wade.

P. Meffre and Z. Benfodda jointly supervised this work.

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Boibessot, T., Bénimélis, D., Meffre, P. et al. Advances in the synthesis of α-quaternary α-ethynyl α-amino acids. Amino Acids 48, 2081–2101 (2016). https://doi.org/10.1007/s00726-016-2276-2

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