Amino Acids

, Volume 48, Issue 7, pp 1533–1540 | Cite as

Methionine restriction on lipid metabolism and its possible mechanisms

  • Xihong Zhou
  • Liuqin He
  • Dan Wan
  • Huansheng Yang
  • Kang Yao
  • Guoyao Wu
  • Xin WuEmail author
  • Yulong YinEmail author
Review Article


Methionine restriction (MR) exerts many beneficial effects, such as increasing longevity, decreasing oxidative damage and alleviating inflammatory responses. Much attention has been recently focused on the effects of MR on metabolic health, especially lipid metabolism, since the increasing incidence of obesity, insulin resistance and type 2 diabetes causes a worldwide health problem. In general, MR is considered to increase de novo lipogenesis, lipolysis and fatty acid oxidation, with a result of reduced fat accumulation. However, different responses in lipid metabolism between adipose tissue and liver are declared. Therefore, in this review, we will focus on the changes of lipid metabolism responses to dietary MR. Moreover, the comparison of alterations of fat metabolism responses to dietary MR between adipose tissue and liver, and the comparison of changes between rodents and pigs is made to illustrate the tissue- and species-specific responses. In addition, the possible mechanisms that might be engaged in the regulation of MR diet on lipid metabolism are also discussed.


Methionine restriction Fat accumulation Adipose tissue Liver 



This work was supported by National Basic Research Program of China (2013CB127301, 2013CB127306), National Natural Science Foundation of China (31402089) and National Science and Technology Support Project (2013BAD21B04).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.


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© Springer-Verlag Wien 2016

Authors and Affiliations

  1. 1.Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central, Ministry of AgricultureHunan Provincial Engineering Research Center of Healthy Livestock and PoultryChangshaChina
  2. 2.University of the Chinese Academy of SciencesBeijingChina
  3. 3.Texas A&M UniversityCollege StationUSA

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