Amino Acids

, Volume 48, Issue 7, pp 1601–1617 | Cite as

Effects of taurine on gut microbiota and metabolism in mice

  • Haining Yu
  • Zhengzhao Guo
  • Shengrong ShenEmail author
  • Weiguang Shan
Original Article


As being a necessary amino acid, taurine plays an important role in the regulation of neuroendocrine functions and nutrition. In this study, effects of taurine on mice gut microbes and metabolism were investigated. BALB/C mice were randomly divided into three experimental groups: The first group was administered saline (CK), the second was administered 165 mg/kg natural taurine (NE) and the third one administered 165 mg/kg synthetic taurine (CS). Gut microbiota composition in mice feces was analyzed by metagenomics technology, and the content of short-chain fatty acids (SCFA) in mice feces was detected by gas chromatography (GC), while the concentrations of lipopolysaccharide (LPS) and superoxide dismutase (SOD) were detected by a LPS ELISA kit and a SOD assay kit, respectively. The results showed that the effect of taurine on gut microbiota could reduce the abundance of Proteobacteria, especially Helicobacter. Moreover, we found that the SCFA content was increased in feces of the NE group while LPS content was decreased in serum of the NE group; the SOD activity in serum and livers of the NE and CS groups were not changed significantly compare to that of the CK group. In conclusion, taurine could regulate the gut micro-ecology, which might be of benefit to health by inhibiting the growth of harmful bacteria, accelerating the production of SCFA and reducing LPS concentration.


Taurine Gut microbiota Metagenomics technology SCFA LPS SOD activity 


Compliance with ethical standards


There is no fund support for this research.

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving animals were in accordance with the guidelines issued by the Ethical Committee of Zhejiang University (SYXK(zhe)2012-0178).


  1. Asarat M, Vasiljevic T, Apostolopoulos V, Donkor O (2015) Short-chain fatty acids regulate secretion of IL-8 from human intestinal epithelial cell lines in vitro. Immunol Invest 44(7):678–693CrossRefPubMedGoogle Scholar
  2. Averin E (2015) Use of taurine during rehabilitation after cardiac surgery. Adv Exp Med Biol 803:637–649CrossRefPubMedGoogle Scholar
  3. Bhutia YD, Ganapathy V (2015) Short, but smart: SCFAs train T cells in the gut to fight autoimmunity in the brain. Immunity 43(4):629–631CrossRefPubMedGoogle Scholar
  4. Camargo RL, Batista TM, Ribeiro RA, Branco RC, Da Silva PM, Izumi C, Araujo TR, Greene LJ, Boschero AC, Carneiro EM (2015) Taurine supplementation preserves hypothalamic leptin action in normal and protein-restricted mice fed on a high-fat diet. Amino Acids 47(11):2419–2435CrossRefPubMedGoogle Scholar
  5. Cuttitta CM, Guariqlia SR, Idrissi AE, L’amoreaux WJ (2013) Taurine’s effects on the neuroendocrine functions of pancreatic β cells. Adv Exp Med Biol 775:299–310CrossRefPubMedGoogle Scholar
  6. De Luca A, Pierno S, Camerino DC (2015) Taurine: the appeal of a safe amino acid for skeletal muscle disorders. J Transl Med 13:243–261CrossRefPubMedPubMedCentralGoogle Scholar
  7. Dogra S, Sakwinska O, Soh SE, Ngom-Bru C, Brück WM, Berger B, Brüssow H, Karnani N, Lee YS, Yap F, Chong YS, Godfrey KM, Holbrook JD (2015) Rate of establishing the gut microbiota in infancy has consequences for future health. Gut Microbes 6(5):321–325CrossRefPubMedPubMedCentralGoogle Scholar
  8. Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, Gill SR, Nelson KE, Relman DA (2005) Diversity of the human intestinal microbial flora. Science 308:1635–1638CrossRefPubMedPubMedCentralGoogle Scholar
  9. Edgar RC (2010) Search and clustering orders of magnitude faster than BLAST. Bioinformatics 36(19):2460–2461CrossRefGoogle Scholar
  10. Huxtable RJ (1992) Physiological actions of taurine. Physiol Rev 72:101–163PubMedGoogle Scholar
  11. Ito T, Schaffer SW, Azuma J (2012) The potential usefulness of taurine on diabetes mellitus and its complications. Amino Acids 42(5):1529–1539CrossRefPubMedGoogle Scholar
  12. Kim DH, Park MH, Chung KW, Kim MJ, Park D, Lee B, Lee EK, Choi YJ, Kim ND, Yu BP, Chung HY (2015) Suppression of FoxO6 by lipopolysaccharide in aged rat liver. Oncotarget 6(33):34143–34157PubMedPubMedCentralGoogle Scholar
  13. Lan YM, Wang Q, Cole JR, Rosen GL (2012) Using the RDP Classifier to predict taxonomic novelty and reduce the search space for finding novel organisms. PLoS One 7(3):e32491CrossRefPubMedPubMedCentralGoogle Scholar
  14. Okawa S, Unuma K, Yamada A, Aki T, Uemura K (2015) Lipopolysaccharide induces expression of collagen VI in the rat lung. J Toxicol Pathol 28(1):37–41CrossRefPubMedGoogle Scholar
  15. Tremaroli V, Backhed F (2012) Functional interactions between the gut microbiota and host metabolism. Nature 489(7415):242–249CrossRefPubMedGoogle Scholar
  16. Wang C, Li L, Guan H, Tong S, Liu M, Liu C, Zhang Z, Du C, Li P (2013) Effects of taurocholic acid on immunoregulation in mice. Int Immunopharmacol 15(2):217–222CrossRefPubMedGoogle Scholar
  17. Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, Nagler CR, Ismagilov RF, Mazmanian SK, Hsiao EY (2015) Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell 161(2):264–276CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Wien 2016

Authors and Affiliations

  • Haining Yu
    • 1
  • Zhengzhao Guo
    • 1
  • Shengrong Shen
    • 2
    Email author
  • Weiguang Shan
    • 1
  1. 1.College of Pharmaceutical SciencesZhejiang University of TechnologyHangzhouPeople’s Republic of China
  2. 2.Department of Food Science and NutritionCollege of Biosystems Engineering and Food Science, Zhejiang UniversityHangzhouPeople’s Republic of China

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