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Amino Acids

, Volume 47, Issue 7, pp 1399–1408 | Cite as

Effect of the external electric field on selected tripeptides

  • Józef Mazurkiewicz
  • Henryk Kołoczek
  • Piotr TomasikEmail author
Original Article

Abstract

The effect of external electric field (EEF) of 5.14, 25.70, and 51.40 MV/cm upon Cys-Asn-Ser, Glu-Arg-Leu, Glu-Cys-Glc, Ser-Asp-Leu, Ser-Glu-Met tripeptide inner salts was simulated involving HyperChem 8.0 software together with the AM1 method for optimization of the molecules’ conformation. The reaction to EEF is diverse and specific to particular peptides. EEF stimulated an increase in the positive charge density on the hydrogen atoms of the N+H3, peptide bond NH, NH2, and COOH groups as well decrease in the negative charge density on the oxygen atoms of the peptide bond carbonyl groups. Thus, EEF could control behavior and action of tripeptides, such as an increase in their catalytic activity.

Keywords

Cys-Asn-Ser Glu-Arg-Leu Glu-Cys-Glc Ser-Asp-Leu Ser-Glu-Met 

Notes

Conflict of interest

The authors of the submitted text (Effect of external electric field on selected tripeptides) know nothing about potential conflict of interest between us and known to us researchers involved in the peptide study.

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Copyright information

© Springer-Verlag Wien 2015

Authors and Affiliations

  • Józef Mazurkiewicz
    • 1
  • Henryk Kołoczek
    • 2
  • Piotr Tomasik
    • 3
    Email author
  1. 1.Department of Chemistry and PhysicsUniversity of AgricultureKrakówPoland
  2. 2.Department of Inorganic Technology and Environmental BiotechnologyCracow University of TechnologyKrakówPoland
  3. 3.Krakow College of Health PromotionKrakowPoland

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