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Amino Acids

, Volume 46, Issue 10, pp 2427–2433 | Cite as

A concise synthesis of benzimidazoles via the microwave-assisted one-pot batch reaction of amino acids up to a 10-g scale

  • Pai Peng
  • Jin-Feng Xiong
  • Guang-Zhen Mo
  • Jia-Li Zheng
  • Ren-Hong Chen
  • Xiao-Yun ChenEmail author
  • Zhao-Yang WangEmail author
Original Article

Abstract

An efficient method for the synthesis of aminomethyl benzimidazoles is developed by using a one-pot batch reaction between amino acids and o-phenylenediamines. This reaction proceeds smoothly in an unmodified household microwave oven, even though scale-up is to 10 g. A desirable method for the quick synthesis of benzimidazoles, which are used as a kind of important intermediates in drug synthesis, is provided by the scale-up utilization of amino acid resource.

Keywords

Benzimidazoles One-pot synthesis Amino acids o-Phenylenediamine Microwave irradiation 

Notes

Acknowledgments

We are grateful to the Third Talents Special Funds of Guangdong Higher Education (No. Guangdong-Finance-Education [2,011]431), the National Natural Science Foundation of China (No. 20772035) and the Natural Science Foundation of Guangdong Province (No. S2011010001556) for financial support.

Conflict of interest

The authors declare no completing financial interest.

Supplementary material

726_2014_1794_MOESM1_ESM.pdf (436 kb)
Supplementary material 1 (PDF 435 kb)

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Copyright information

© Springer-Verlag Wien 2014

Authors and Affiliations

  • Pai Peng
    • 1
  • Jin-Feng Xiong
    • 1
  • Guang-Zhen Mo
    • 1
  • Jia-Li Zheng
    • 1
  • Ren-Hong Chen
    • 2
  • Xiao-Yun Chen
    • 3
    Email author
  • Zhao-Yang Wang
    • 1
    Email author
  1. 1.Key Laboratory of Theoretical Chemistry of Environment, Ministry of EducationSchool of Chemistry and Environment, South China Normal UniversityGuangzhouPeople’s Republic of China
  2. 2.Guangdong Food and Drug Vocational CollegeGuangzhouPeople’s Republic of China
  3. 3.Institute of Organic Chemistry, RWTH Aachen UniversityAachenGermany

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