A concise synthesis of benzimidazoles via the microwave-assisted one-pot batch reaction of amino acids up to a 10-g scale
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An efficient method for the synthesis of aminomethyl benzimidazoles is developed by using a one-pot batch reaction between amino acids and o-phenylenediamines. This reaction proceeds smoothly in an unmodified household microwave oven, even though scale-up is to 10 g. A desirable method for the quick synthesis of benzimidazoles, which are used as a kind of important intermediates in drug synthesis, is provided by the scale-up utilization of amino acid resource.
KeywordsBenzimidazoles One-pot synthesis Amino acids o-Phenylenediamine Microwave irradiation
We are grateful to the Third Talents Special Funds of Guangdong Higher Education (No. Guangdong-Finance-Education [2,011]431), the National Natural Science Foundation of China (No. 20772035) and the Natural Science Foundation of Guangdong Province (No. S2011010001556) for financial support.
Conflict of interest
The authors declare no completing financial interest.
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