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Functional implications of hippocampal adult neurogenesis in intellectual disabilities

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Abstract

The development of strategies capable to promote nervous system plasticity in adulthood is nowadays an important aim in neuroscience to improve not only cognitive abilities but also to ameliorate pathological dysfunctions. Several studies have demonstrated that adult neurogenesis is regulated by many physiological and pathological stimuli at almost every stage, from proliferation of neuronal precursors until integration and activation of newly formed neurons in the preexisting network. We review the process of generating functional neurons from precursors in the adult brain and its implications in intellectual disability disorders.

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Acknowledgments

Jérôme Lejeune Foundation, Catalan Agency for Administration of University and Research Grants (AGAUR: 2009SGR718 and 2009SGR1313), Spanish Ministry of Education and Sciences (SAF2010-16427) EU (CURE-FXS, EU/FIS-PS09102673) FRAXA Foundation.

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  1. Systems Biology Program, Centre for Genomic Regulation (CRG), Dr. Aiguader 88, 08003, Barcelona, Spain

    Meritxell Pons-Espinal, Maria Martinez de Lagran & Mara Dierssen

  2. Universitat Pompeu Fabra (UPF), Dr. Aiguader 88, 08003, Barcelona, Spain

    Meritxell Pons-Espinal, Maria Martinez de Lagran & Mara Dierssen

  3. Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Dr. Aiguader 88, 08003, Barcelona, Spain

    Meritxell Pons-Espinal, Maria Martinez de Lagran & Mara Dierssen

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  1. Meritxell Pons-Espinal
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Pons-Espinal, M., de Lagran, M.M. & Dierssen, M. Functional implications of hippocampal adult neurogenesis in intellectual disabilities. Amino Acids 45, 113–131 (2013). https://doi.org/10.1007/s00726-013-1489-x

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