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Modulating protein activity and cellular function by methionine residue oxidation

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Abstract

The sulfur-containing amino acid residue methionine (Met) in a peptide/protein is readily oxidized to methionine sulfoxide [Met(O)] by reactive oxygen species both in vitro and in vivo. Methionine residue oxidation by oxidants is found in an accumulating number of important proteins. Met sulfoxidation activates calcium/calmodulin-dependent protein kinase II and the large conductance calcium-activated potassium channels, delays inactivation of the Shaker potassium channel ShC/B and L-type voltage-dependent calcium channels. Sulfoxidation at critical Met residues inhibits fibrillation of atherosclerosis-related apolipoproteins and multiple neurodegenerative disease-related proteins, such as amyloid beta, α-synuclein, prion, and others. Methionine residue oxidation is also correlated with marked changes in cellular activities. Controlled key methionine residue oxidation may be used as an oxi-genetics tool to dissect specific protein function in situ.

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Acknowledgments

Work supported by The MOST China “973” Program (2011CB809101), by NSFC (No. 30728020, 30870580; 30970675), and by NSFBJ (No. 5102020).

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Authors and Affiliations

  1. Institute of Cell Biology, Beijing Normal University, Beijing, 100875, China

    Zong Jie Cui, Zong Qiang Han & Zhi Ying Li

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  1. Zong Jie Cui
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  2. Zong Qiang Han
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  3. Zhi Ying Li
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Correspondence to Zong Jie Cui.

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Cui, Z.J., Han, Z.Q. & Li, Z.Y. Modulating protein activity and cellular function by methionine residue oxidation. Amino Acids 43, 505–517 (2012). https://doi.org/10.1007/s00726-011-1175-9

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  • DOI: https://doi.org/10.1007/s00726-011-1175-9

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