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New 1,3-amino alcohols derived from enantiopure bridgehead β-aminobicyclo[2.2.2]oct-5-ene-2-carboxylic acids

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Abstract

Constrained enantiopure bicyclic β-amino acids derived from the asymmetric Diels–Alder reaction of the (R)-benzyl-4-(3-acryloyloxy-4,4-dimethyl-2-oxopyrrolidin-1-yl)-benzoate and the 1-(benzyloxycarbonylamino)cyclohexadiene provide original templates for the construction of new rigid enantiopure 1,3-amino alcohols.

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Acknowledgments

The authors gratefully acknowledge the CNRS and the MESR for their financial support.

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Authors and Affiliations

  1. Institut des Biomolécules Max Mousseron (IBMM) UMR 5247 CNRS-Université Montpellier 1 et 2, Bâtiment Chimie (17), Université Montpellier 2, place E. Bataillon, 34095, Montpellier Cedex 5, France

    Christophe André, Monique Calmès, Françoise Escale, Muriel Amblard, Jean Martinez & Olivier Songis

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  1. Christophe André
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  2. Monique Calmès
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  3. Françoise Escale
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Correspondence to Monique Calmès.

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André, C., Calmès, M., Escale, F. et al. New 1,3-amino alcohols derived from enantiopure bridgehead β-aminobicyclo[2.2.2]oct-5-ene-2-carboxylic acids. Amino Acids 43, 415–421 (2012). https://doi.org/10.1007/s00726-011-1097-6

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