Abstract
The bursa of Fabricius (BF) is the central humoral immune organ unique to birds. Here, we isolated a novel bursal pentapeptide I (BPP-I), LGPGP, from BF. BPP-I could play inhibition effect on MCF-7 but not on CEF or Vero cell proliferation in vitro, and enhance antitumor factor p53 protein expression. Also, BPP-I stimulated antibody production in a dose-dependent manner in hybridoma cell. Furthermore, BPP-I could induce various immune responses in mice immunization experiments, including increase antibody production and cytokines IL-4 and IFN-γ level, and induce T-cell immunophenotyping. These results suggest that BPP-I is a potential immunomodulator of antitumor and immunity. The study could provide some novel insights on the probable candidate reagent for the antitumor and immune improvement.
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Acknowledgements
This work was supported by the National Agriculture Special Research Project for Non-Profit Trades, Ministry of Agriculture (No. 200803020). Also, we thank Elsevier Language Editing Services (https://languageediting.elsevier.com/) for professional language editing service in the preparation of this manuscript.
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Feng, X.L., Liu, Q.T., Cao, R.B. et al. A bursal pentapeptide (BPP-I), a novel bursal-derived peptide, exhibits antiproliferation of tumor cell and immunomodulator activity. Amino Acids 42, 2215–2222 (2012). https://doi.org/10.1007/s00726-011-0961-8
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DOI: https://doi.org/10.1007/s00726-011-0961-8