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Synthesis of camptothecin–amino acid carbamate linkers

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Abstract

A more convenient and facile approach for the synthesis and production of camptothecin–amino acids carbamate linkers, that can be used in the synthesis of bioconjugate peptides JF-10-81, JF-10-71, and other peptide analogs designed to target somatostatin receptors has been described.

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Acknowledgments

We thank LSU Mass Spectrometry Facility for ESI-MS analysis and technical assistance.

Conflict of interest

M.A. Etienne, M. Kostochka, J.A. Fuselier, D. H. Coy, and Tulane University have proprietary rights to amino acid carbamate linkers and somatostatin conjugates described herein.

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Authors and Affiliations

  1. Peptide Research Laboratories, Department of Medicine, Tulane Health Sciences Center, Tulane University School of Medicine, New Orleans, LA, 70112-2699, USA

    Marcus A. Etienne, Mikhail Kostochka, Joseph A. Fuselier & David H. Coy

Authors
  1. Marcus A. Etienne
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  2. Mikhail Kostochka
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  3. Joseph A. Fuselier
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  4. David H. Coy
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Corresponding author

Correspondence to Joseph A. Fuselier.

Additional information

M.A. Etienne and M. Kostochka contributed equally to this manuscript.

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Etienne, M.A., Kostochka, M., Fuselier, J.A. et al. Synthesis of camptothecin–amino acid carbamate linkers. Amino Acids 42, 1727–1733 (2012). https://doi.org/10.1007/s00726-011-0884-4

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  • DOI: https://doi.org/10.1007/s00726-011-0884-4

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