Amino Acids

, Volume 41, Issue 4, pp 933–936 | Cite as

A new approach to 3-substituted tetrahydro-β-carboline derivative via diethyl acetamidomalonate

  • Sambasivarao KothaEmail author
  • Shilpi Misra
  • Shaikh M. Mobin
Original Article


Strategically a new approach for the synthesis tetrahydro-β-carboline unit with the aid of diethyl acetamidomalonate as a glycine equivalent has been described.


Diethyl acetamidomalonate Indole alkaloids Tetrahydro-β-carboline Unusual α-amino acid derivatives 



We are grateful to DST and CSIR for the financial support and SAIF Mumbai for providing the spectral data. S. M. thank CSIR (New Delhi) for the award of research fellowship. S. K. thank DST for the award of J. C. Bose fellowship.


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Sambasivarao Kotha
    • 1
    Email author
  • Shilpi Misra
    • 1
  • Shaikh M. Mobin
    • 1
  1. 1.Department of ChemistryIndian Institute of Technology-BombayMumbaiIndia

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