Abstract
Biogenic amines and polyamines are organic polycations derived from aromatic or cationic amino acids. They exert pleiotropic effects, more related to intercellular communication in the case of biogenic amines, and to intracellular signaling in the case of polyamines. The bioactive compound epigallocatechin-3-gallate (EGCG), a major component of green tea, has been shown to target key enzyme of biogenic amine and polyamine metabolic pathways. Herein, we review the specific effects of EGCG on concrete molecular targets of both biogenic amine and polyamine metabolic pathways, and discuss the relevance of these data to support the potential therapeutic interest of this compound.
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Abbreviations
- EC:
-
Epicatechin
- ECG:
-
Epicatechin-3-gallate
- EGC:
-
Epigallocatechin
- EGCG:
-
Epigallocatechin-3-gallate
- DDC:
-
Dopa decarboxylase
- HDC:
-
Histidine decarboxylase
- MCP-1:
-
Monocyte chemoattractant protein 1
- ODC:
-
Ornithine decarboxylase
- SAMDC:
-
S-adenosyl methionine decarboxylase
- SSAT:
-
Spermidine/spermine N-acetyl transferase
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Acknowledgments
The experimental work carried out by our group is supported by grants SAF 2008-02522 (Spanish Ministry of Science and Innovation), Fundación Ramón Areces, P07-CVI-02999 and group BIO-267 (Andalusian Government). The “CIBER de Enfermedades Raras” is an initiative of the ISCIII (Spain).
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Melgarejo, E., Urdiales, J.L., Sánchez-Jiménez, F. et al. Targeting polyamines and biogenic amines by green tea epigallocatechin-3-gallate. Amino Acids 38, 519–523 (2010). https://doi.org/10.1007/s00726-009-0411-z
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DOI: https://doi.org/10.1007/s00726-009-0411-z