Abstract
The changes in the concentrations of plasma amino acids do not always follow the flow-based metabolic pathway network. We have previously shown that there is a control-based network structure among plasma amino acids besides the metabolic pathway map. Based on this network structure, in this study, we performed dynamic analysis using time-course data of the plasma samples of rats fed single essential amino acid deficient diet. Using S-system model (conceptual mathematical model represented by power-law formalism), we inferred the dynamic network structure which reproduces the actual time-courses within the error allowance of 13.17%. By performing sensitivity analysis, three of the most dominant relations in this network were selected; the control paths from leucine to valine, from methionine to threonine, and from leucine to isoleucine. This result is in good agreement with the biological knowledge regarding branched-chain amino acids, and suggests the biological importance of the effect from methionine to threonine.
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Acknowledgment
This work was partially supported by Grants-in-Aid for Scientific Research (c) [No. 18500228(YM)] and Scientific Research on Priority Areas, ‘New IT Infrastructure for the Information-explosion Era’ [No. 18049073(MO)] from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
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Shikata, N., Maki, Y., Nakatsui, M. et al. Determining important regulatory relations of amino acids from dynamic network analysis of plasma amino acids. Amino Acids 38, 179–187 (2010). https://doi.org/10.1007/s00726-008-0226-3
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DOI: https://doi.org/10.1007/s00726-008-0226-3