Abstract
In order to explore the interrelationship between plasma and cerebrospinal fluid taurine concentrations, three consecutive 6-ml fractions of cerebrospinal fluid were drawn from 30 healthy male volunteers in the early morning after 8 h in the fasting condition. Repeated plasma samples were drawn over 24 h the day before lumbar puncture. Taurine in plasma and cerebrospinal fluid was determined by high performance liquid chromatography. The subjects were categorized as extensive or poor metabolizers with respect to the cytochrome P450 2D6 genotype. The taurine cerebrospinal fluid/plasma ratio at 8 a.m. was negatively influenced by the plasma taurine concentration at 4 p.m. the previous day. It was also negatively influenced by body mass index and positively by the intraspinal pressure. Three poor metabolizers of cytochrome P450 2D6 had higher plasma taurine areas under the curve than 27 extensive metabolizers. Hypothetically, cytochrome P450 2D6 influences the transport of taurine across the blood–brain barrier.
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Acknowledgments
The study was supported by grants from the Östergötland County Council. We thank the Department of Chemistry, University Hospital MAS, Malmö, Sweden, for the analysis of taurine. We also thank our research nurses, Mrs. Hazel Holmberg-Forsyth and Mrs. Margareta Krona, for their most excellent assistance and Associate Professor Lars Bjerkenstedt for his fruitful comments.
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Samuelsson, M., Dahl, ML., Gupta, R.C. et al. Taurine in plasma and CSF: a study in healthy male volunteers. Amino Acids 36, 529–533 (2009). https://doi.org/10.1007/s00726-008-0115-9
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DOI: https://doi.org/10.1007/s00726-008-0115-9