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Novel deprotection method of Fmoc group under neutral hydrogenation conditions

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Abstract

Novel deprotection method of the Fmoc (9-flurorenylmethoxycarbonyl) protective group under Pd/C-catalyzed hydrogenation conditions at room temperature was developed. The addition of CH3CN accelerated the deprotection of the Fmoc group, and also the application of H2 pressure (3 atm) shows notable rate enhancement.

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Acknowledgment

We thank N. E. Chemcat Corporation for a gift of 10% Pd/C.

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Correspondence to Hironao Sajiki.

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Maegawa, T., Fujiwara, Y., Ikawa, T. et al. Novel deprotection method of Fmoc group under neutral hydrogenation conditions. Amino Acids 36, 493–499 (2009). https://doi.org/10.1007/s00726-008-0109-7

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  • DOI: https://doi.org/10.1007/s00726-008-0109-7

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