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Amino Acids

, Volume 35, Issue 2, pp 397–402 | Cite as

Heme oxygenase-1 participates in the anti-inflammatory activity of taurine chloramine

  • B. Muż
  • E. Kontny
  • J. Marcinkiewicz
  • W. Maśliński
Article

Summary.

Interleukin-6 (IL-6) and interleukin-8 (IL-8) are implicated in the pathogenesis of rheumatic diseases. In affected joints fibroblast-like synoviocytes (FLS) are the major source of these pro-inflammatory cytokines. We have previously found that production of both cytokines is inhibited in vitro by taurine chloramine (Tau-Cl). Heme oxygenase (HO-1) activity was also reported to restrict synthesis of various inflammatory mediators, including IL-6 and IL-8. The aim of present study was to investigate whether this enzyme activity is implicated in the mechanism of Tau-Cl suppressive effect. We have shown that in rheumatoid FLS both hemin (known HO-1 inducer) and Tau-Cl significantly up-regulate HO-1 expression at the mRNA and protein levels and simultaneously inhibit IL-1β-triggered production of pro-inflammatory cytokines. However, the inhibitory potency of these compounds differs, because hemin is more potent inhibitor of IL-8 than IL-6 production, while Tau-Cl exerts opposite effect. Importantly, pretreatment of the cells with HO-1 inhibitor completely reverses the inhibitory effect of hemin on both cytokines production. However, in Tau-Cl treated cells this inhibitor fully restores only IL-8 secretion but has weaker effect on IL-6 response. Thus, the present results: (i) support HO-1 activity to be relevant to negatively control production of pro-inflammatory cytokines, and (ii) underline implication of HO-1 in mediating Tau-Cl inhibitory action.

Keywords: Interleukins (IL) – Fibroblast-like synoviocytes (FLS) – Rheumatoid arthritis (RA) – Heme oxygenase-1 (HO-1) – Taurine chloramine (Tau-Cl) 

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Copyright information

© Springer-Verlag 2008

Authors and Affiliations

  • B. Muż
    • 1
  • E. Kontny
    • 1
  • J. Marcinkiewicz
    • 2
  • W. Maśliński
    • 1
  1. 1.Department of Pathophysiology and ImmunologyInstitute of RheumatologyWarsawPoland
  2. 2.Department of ImmunologyMedical College, Jagiellonian UniversityCracowPoland

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