β-Lactoglobulin as source of bioactive peptides
- 1.1k Downloads
β-Lactoglobulin (β-Lg) is currently an important source of biologically active peptides. These peptides are inactive within the sequence of the precursor protein, but they can be released by in vivo or in vitro enzymatic proteolysis. Once released, these peptides play important roles in the human health, including antihypertensive, antioxidant and antimicrobial activities as well as opioid-like features and ability to decrease the body-cholesterol levels. Bioactive peptides derived from β-Lg are currently a point of intensive research. Their structure, biological significance and mechanism of action are briefly presented and discussed in this review.
Unable to display preview. Download preview PDF.
- Brautnizer, G, Chen, R, Schrank, B, Stangl, A 1973Die Sequenzanalyse des β-LactoglobulinsHoppe Seyler’s Z Physiol Chem354867878Google Scholar
- Dalgalarrondo, M, Chobert, JM, Dufour, E, Bertrand-Harb, C, Dumont, JP, Haertle, T 1990Characterization of bovine β-lactoglobulin B tryptic peptides by reverse-phase high performance liquid chromatographyMilchwissenschaft45212216Google Scholar
- de Witt, JN 1998Nutritional and functional characteristics of whey proteins in food productsJ Dairy Sci81597608Google Scholar
- Eigel, WN, Butler, JE, Ernstrom, CA, Farrell, HM,Jr, Harwalkar, VR, Jenness, R, Whiney, RMcL 1984Nomenclature of proteins of cows milk: Fifth revisionJ Dairy Sci6715991631Google Scholar
- El-Zahar, K, Sitohy, M, Choiset, Y, Metro, F, Haertlé, T, Chobert, JM 2004Antimicrobial activity of ovine whey protein and their peptic hydrolysatesMilchwissenschaft59653656Google Scholar
- Gobbetti, M, Ferranti, P, Smacchi, E, Goffredi, F, Addeo, F 2000Production of angiotensin-I-converting-enzyme-inhibitory peptides in fermented milks started by Lactobacillus delbrueckii subsp. bulgaricus SS1 and Lactococcus lactis subsp. cremoris FT4Appl Environ Microbiol6638983904PubMedCrossRefGoogle Scholar
- Hambling, SG, McAlpine, AS, Sawyer, L 1992β-lactoglobulinFox, PF eds. Advanced Dairy Chemistry IElsevierAmsterdam141190Google Scholar
- Hambraeus, L, Lönnerdal, B 2003Nutritional aspects of milk proteinsFox, PFMcSweeney, PLHM eds. Advanced Dairy Chemistry (I. Proteins 3rd edn, Part B)KluwerNew York606645Google Scholar
- Hernández-Ledesma B, Miguel M, Amigo L, Aleixandre MA, Recio I (2007a) Effect of simulated gastrointestinal digestion on the antihypertensive properties of β-lactoglobulin peptides. J Dairy Res 74: doi:10.1017/S0022029907002609Google Scholar
- Nagaoka, S, Kanamaru, Y, Kuzuya, Y 1991Effects of whey-protein and casein on the plasma and liver lipids in ratsAgric Biol Chem55813818Google Scholar
- Yoshikawa M, Sasaki R, Chiba H, Tani F (1991) Japan Kokai Tokkyo Koho, 220197 (Sep. 27)Google Scholar