Amino Acids

, Volume 35, Issue 2, pp 275–281 | Cite as

Experimental study on vasoactive intestinal peptide (VIP) and its diaminopropane bound (VIP-DAP) analog in solution

  • M. Caraglia
  • M. Carteni
  • A. Dicitore
  • D. Cassese
  • S. De Maria
  • P. Ferranti
  • G. Giuberti
  • A. Abbruzzese
  • P. Stiuso
Review Article


Bioactive peptides represent an exciting area of research in the fields of biochemistry and medicine and in particular the VIP/PACAP network appears to be of interest. Vasoactive intestinal peptide (VIP) is a pleiotropic factor that exerts a physiological regulatory influence and is involved in the pathogenesis of several human disorders. In this paper we have reported structural characterization of VIP by experimental and computational methods as well as a comparative analysis of the peptide with its transglutaminase catalyzed analog VIP-Diaminopropane (VIP-DAP).

Keywords: Vasoactive intestinal peptide (VIP) – Transglutaminase (TGase) – Limited proteolysis – Computational study – VPAC receptors 



cyclic AMP


CREB binding protein


cAMP responsive element


CRE-binding protein


cytokine response element


gamma activated sequences


interferon gamma


interleukin 6


inducible nitric oxide synthase


interferon regulatory factor 1




Pituary adenylate cyclase-activating polypeptide


protein kinase A


tumor necrosis factor α


vasoactive intestinal peptide


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • M. Caraglia
    • 1
  • M. Carteni
    • 2
  • A. Dicitore
    • 3
  • D. Cassese
    • 3
  • S. De Maria
    • 2
  • P. Ferranti
    • 4
  • G. Giuberti
    • 3
  • A. Abbruzzese
    • 3
  • P. Stiuso
    • 3
  1. 1.Dipartimento di Oncologia SperimentaleIstituto Nazionale Tumori “Fondazione G. Pascale”NaplesItaly
  2. 2.Dipartimento di Medicina SperimentaleSeconda Università degli Studi di NapoliNapoliItaly
  3. 3.Dipartimento di Biochimica e BiofisicaSeconda Università degli Studi di NapoliNapoliItaly
  4. 4.Dipartimento di Scienza degli AlimentiUniversità di Napoli “Federico II”, Parco GussonePorticiItaly

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