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Absorption, tissue distribution, metabolism and elimination of taurine given orally to rats

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Summary.

Three biodisposition studies with taurine were performed in male and female adult rats at dosages of 30 and 300 mg/kg. A single oral dose of 14C-taurine was rapidly absorbed, distributed to tissues and excreted unchanged in urine. Elimination of radioactivity from intracellular pools was slow. Pre-treatment of animals for 14 days with unlabelled taurine did not significantly affect the fate of 14C-taurine. At the higher dose there was more extensive excretion combined with a lower percentage of the dose in the carcass, indicating the possibility of saturation of the tubular reabsorption mechanism for taurine. Daily administration of unlabelled taurine for 14 days did not result in an increase in total taurine in the brain. The data indicate that exogenous taurine rapidly equilibrates with endogenous body pools and that any excess is rapidly eliminated by the kidneys.

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Authors and Affiliations

  1. WIL Research Laboratories, LLC, Ashland, OH, U.S.A.

    D. W. Sved, J. L. Godsey, S. L. Ledyard, A. P. Mahoney, P. L. Stetson, S. Ho, N. R. Myers & P. Resnis

  2. School of Medicine, University of Southampton, Southampton, U.K.

    A. G. Renwick

Authors
  1. D. W. Sved
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  2. J. L. Godsey
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  3. S. L. Ledyard
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  4. A. P. Mahoney
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  5. P. L. Stetson
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  6. S. Ho
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  7. N. R. Myers
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  8. P. Resnis
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  9. A. G. Renwick
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Sved, D., Godsey, J., Ledyard, S. et al. Absorption, tissue distribution, metabolism and elimination of taurine given orally to rats. Amino Acids 32, 459–466 (2007). https://doi.org/10.1007/s00726-007-0494-3

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  • DOI: https://doi.org/10.1007/s00726-007-0494-3

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