Skip to main content
SpringerLink
Log in

Structural properties of proteins specific to the myelin sheath

  • Review Article
  • Published:
Amino Acids Aims and scope Submit manuscript

Summary.

The myelin sheath is an insulating membrane layer surrounding myelinated axons in vertebrates, which is formed when the plasma membrane of an oligodendrocyte or a Schwann cell wraps itself around the axon. A large fraction of the total protein in this membrane layer is comprised of only a small number of individual proteins, which have certain intriguing structural properties. The myelin proteins are implicated in a number of neurological diseases, including, for example, autoimmune diseases and peripheral neuropathies. In this review, the structural properties of a number of myelin-specific proteins are described.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

P0:

myelin protein zero

MAG:

myelin-associated glycoprotein

MOG:

myelin/oligodendrocyte glycoprotein

MBP:

myelin basic protein

MOBP:

myelin/oligodendrocyte basic protein

CaM:

calmodulin

P2:

peripheral myelin protein 2

CNS:

central nervous system

PNS:

peripheral nervous system

OMgp:

oligodendrocyte/myelin glycoprotein

CNPase:

2′,3′-cyclic nucleotide 3′-phosphodiesterase

FABP:

fatty acid binding protein

PnK:

polynucleotide kinase

Ig:

immunoglobulin

References

  • DE Afar JL Salzer J Roder PE Braun JC Bell (1990) ArticleTitleDifferential phosphorylation of myelin-associated glycoprotein isoforms in cell culture J Neurochem 55 1418–1426 Occurrence Handle1697896 Occurrence Handle1:CAS:528:DyaK3cXls12nt7k%3D

    PubMed  CAS  Google Scholar 

  • K Ainger D Avossa AS Diana C Barry E Barbarese JH Carson (1997) ArticleTitleTransport and localization elements in myelin basic protein mRNA J Cell Biol 138 1077–1087 Occurrence Handle9281585 Occurrence Handle1:CAS:528:DyaK2sXlvFKmsbg%3D

    PubMed  CAS  Google Scholar 

  • J Attia L Hicks K Oikawa CM Kay RJ Dunn (1993) ArticleTitleStructural properties of the myelin-associated glycoprotein ectodomain J Neurochem 61 718–726 Occurrence Handle7687661 Occurrence Handle1:CAS:528:DyaK3sXlvFyjs70%3D Occurrence Handle10.1111/j.1471-4159.1993.tb02178.x

    Article  PubMed  CAS  Google Scholar 

  • DR Beniac MD Luckevich GJ Czarnota TA Tompkins RA Ridsdale FP Ottensmeyer MA Moscarello G Harauz (1997) ArticleTitleThree-dimensional structure of myelin basic protein. I. Reconstruction via angular reconstitution of randomly oriented single particles J Biol Chem 272 4261–4268 Occurrence Handle9020142 Occurrence Handle1:CAS:528:DyaK2sXht1OktrY%3D

    PubMed  CAS  Google Scholar 

  • HH Berlet H Bischoff F Weinhardt (1994) ArticleTitleDivalent metals of myelin and their differential binding by myelin basic protein of bovine central nervous system Neurosci Lett 179 75–78 Occurrence Handle7531315 Occurrence Handle1:CAS:528:DyaK2cXmsVyhs7c%3D

    PubMed  CAS  Google Scholar 

  • GL Boccaccio DR Colman (1995) ArticleTitleMyelin basic protein mRNA localization and polypeptide targeting J Neurosci Res 42 277–286 Occurrence Handle8568929 Occurrence Handle1:CAS:528:DyaK2MXosFSku7k%3D

    PubMed  CAS  Google Scholar 

  • CF Boerkoel H Takashima P Stankiewicz CA Garcia SM Leber L Rhee-Morris JR Lupski (2001) ArticleTitlePeriaxin mutations cause recessive Dejerine-Sottas neuropathy Am J Hum Genet 68 325–333 Occurrence Handle11133365 Occurrence Handle1:CAS:528:DC%2BD3MXhtl2ls7c%3D

    PubMed  CAS  Google Scholar 

  • Boggs JM (2006) Myelin basic protein: a multifunctional protein. Cell Mol Life Sci (in press)

  • C Breithaupt A Schubart H Zander A Skerra R Huber C Linington U Jacob (2003) ArticleTitleStructural insights into the antigenicity of myelin oligodendrocyte glycoprotein Proc Natl Acad Sci USA 100 9446–9451 Occurrence Handle12874380 Occurrence Handle1:CAS:528:DC%2BD3sXmtlyktbc%3D

    PubMed  CAS  Google Scholar 

  • JH Carson S Kwon E Barbarese (1998) ArticleTitleRNA trafficking in myelinating cells Curr Opin Neurobiol 8 607–612 Occurrence Handle9811620 Occurrence Handle1:CAS:528:DyaK1cXntlemsb8%3D

    PubMed  CAS  Google Scholar 

  • JH Carson K Worboys K Ainger E Barbarese (1997) ArticleTitleTranslocation of myelin basic protein mRNA in oligodendrocytes requires microtubules and kinesin Cell Motil Cytoskeleton 38 318–328 Occurrence Handle9415374 Occurrence Handle1:CAS:528:DyaK2sXnvFCqtb4%3D

    PubMed  CAS  Google Scholar 

  • A Chmurzynska (2006) ArticleTitleThe multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism J Appl Genet 47 39–48 Occurrence Handle16424607

    PubMed  Google Scholar 

  • CS Clements HH Reid T Beddoe FE Tynan MA Perugini TG Johns CC Bernard J Rossjohn (2003) ArticleTitleThe crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis Proc Natl Acad Sci USA 100 11059–11064 Occurrence Handle12960396 Occurrence Handle1:CAS:528:DC%2BD3sXnslynu7o%3D

    PubMed  CAS  Google Scholar 

  • C Combet C Blanchet C Geourjon G Deleage (2000) ArticleTitleNPS@: network protein sequence analysis Trends Biochem Sci 25 147–150 Occurrence Handle10694887 Occurrence Handle1:CAS:528:DC%2BD3cXhsleiu7Y%3D

    PubMed  CAS  Google Scholar 

  • NK de Rosbo JF Kaye M Eisenstein I Mendel R Hoeftberger H Lassmann R Milo A Ben-Nun (2004) ArticleTitleThe myelin-associated oligodendrocytic basic protein region MOBP15-36 encompasses the immunodominant major encephalitogenic epitope(s) for SJL/J mice and predicted epitope(s) for multiple sclerosis-associated HLA-DRB1*1501 J Immunol 173 1426–1435 Occurrence Handle15240739

    PubMed  Google Scholar 

  • GI Drummond NT Iyer J Keith (1962) ArticleTitleHydrolysis of ribonucleoside 2′,3′-cyclic phosphates by a diesterase from brain J Biol Chem 237 3535–3539

    Google Scholar 

  • L Dytrych DL Sherman CS Gillespie PJ Brophy (1998) ArticleTitleTwo PDZ domain proteins encoded by the murine periaxin gene are the result of alternative intron retention and are differentially targeted in Schwann cells J Biol Chem 273 5794–5800 Occurrence Handle9488714 Occurrence Handle1:CAS:528:DyaK1cXhsleitbY%3D

    PubMed  CAS  Google Scholar 

  • C Earl A Chantry N Mohammad P Glynn (1988) ArticleTitleZinc ions stabilise the association of basic protein with brain myelin membranes J Neurochem 51 718–724 Occurrence Handle2457650 Occurrence Handle1:CAS:528:DyaL1cXmtVOjt7s%3D

    PubMed  CAS  Google Scholar 

  • J Eichberg (2002) ArticleTitleMyelin P0: new knowledge and new roles Neurochem Res 27 1331–1340 Occurrence Handle12512938 Occurrence Handle1:CAS:528:DC%2BD38XpsV2lsrc%3D

    PubMed  CAS  Google Scholar 

  • A El-Amraoui JS Schonn P Kussel-Andermann S Blanchard C Desnos JP Henry U Wolfrum F Darchen C Petit (2002) ArticleTitleMyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes EMBO Rep 3 463–470 Occurrence Handle11964381 Occurrence Handle1:CAS:528:DC%2BD38Xkt1Sru7w%3D

    PubMed  CAS  Google Scholar 

  • JL Everly RO Brady RH Quarles (1973) ArticleTitleEvidence that the major protein in rat sciatic nerve myelin is a glycoprotein J Neurochem 21 329–334 Occurrence Handle4724321 Occurrence Handle1:CAS:528:DyaE3sXltFens7s%3D

    PubMed  CAS  Google Scholar 

  • EH Eylar I Szymanska A Ishaque J Ramwani S Dubiski (1980) ArticleTitleLocalization of the P2 protein in peripheral nerve myelin J Immunol 124 1086–1092 Occurrence Handle6766967 Occurrence Handle1:CAS:528:DyaL3cXhsVeqtbc%3D

    PubMed  CAS  Google Scholar 

  • T Fahrig R Probstmeier E Spiess A Meyer-Franke F Kirchhoff B Drescher M Schachner (1993) ArticleTitleFunctional topography of the myelin-associated glycoprotein. I. Mapping of domains by electron microscopy Eur J Neurosci 5 1118–1126 Occurrence Handle7506618 Occurrence Handle1:STN:280:DyaK2c7gvVKnuw%3D%3D

    PubMed  CAS  Google Scholar 

  • DA Figlewicz RH Quarles D Johnson GR Barbarash NH Sternberger (1981) ArticleTitleBiochemical demonstration of the myelin-associated glycoprotein in the peripheral nervous system J Neurochem 37 749–758 Occurrence Handle6168745 Occurrence Handle1:CAS:528:DyaL3MXltlSjtbk%3D

    PubMed  CAS  Google Scholar 

  • DE Frail PE Braun (1984) ArticleTitleTwo developmentally regulated messenger RNAs differing in their coding region may exist for the myelin-associated glycoprotein J Biol Chem 259 14857–14862 Occurrence Handle6209280 Occurrence Handle1:CAS:528:DyaL2cXmtVyit7s%3D

    PubMed  CAS  Google Scholar 

  • CS Gillespie DL Sherman GE Blair PJ Brophy (1994) ArticleTitlePeriaxin, a novel protein of myelinating Schwann cells with a possible role in axonal ensheathment Neuron 12 497–508 Occurrence Handle8155317 Occurrence Handle1:CAS:528:DyaK2cXmslOhsLk%3D

    PubMed  CAS  Google Scholar 

  • H Gong T Amemiya (2001) ArticleTitleOptic nerve changes in zinc-deficient rats Exp Eye Res 72 363–369 Occurrence Handle11273664 Occurrence Handle1:CAS:528:DC%2BD3MXitFymtLY%3D

    PubMed  CAS  Google Scholar 

  • P Gouet E Courcelle DI Stuart F Metoz (1999) ArticleTitleESPript: analysis of multiple sequence alignments in PostScript Bioinformatics 15 305–308 Occurrence Handle10320398 Occurrence Handle1:CAS:528:DyaK1MXjslCmtrY%3D

    PubMed  CAS  Google Scholar 

  • A Guilbot A Williams N Ravise C Verny A Brice DL Sherman PJ Brophy E LeGuern V Delague C Bareil A Megarbane M Claustres (2001) ArticleTitleA mutation in periaxin is responsible for CMT4F, an autosomal recessive form of Charcot-Marie-Tooth disease Hum Mol Genet 10 415–421 Occurrence Handle11157804 Occurrence Handle1:CAS:528:DC%2BD3MXhsVygt78%3D

    PubMed  CAS  Google Scholar 

  • H Haas CL Oliveira IL Torriani E Polverini A Fasano G Carlone P Cavatorta P Riccio (2004) ArticleTitleSmall angle X-ray scattering from lipid-bound myelin basic protein in solution Biophys J 86 455–460 Occurrence Handle14695288 Occurrence Handle1:CAS:528:DC%2BD2cXlsV2ltA%3D%3D

    PubMed  CAS  Google Scholar 

  • G Harauz N Ishiyama CM Hill IR Bates DS Libich C Fares (2004) ArticleTitleMyelin basic protein-diverse conformational states of an intrinsically unstructured protein and its roles in myelin assembly and multiple sclerosis Micron 35 503–542 Occurrence Handle15219899 Occurrence Handle1:CAS:528:DC%2BD2cXlt1Wjt70%3D

    PubMed  CAS  Google Scholar 

  • Harauz G, Musse AA (2006) A tale of two citrullines – structural and functional aspects of myelin basic protein deimination in health and disease. Neurochem Res (in press)

  • A Holz B Bielekova R Martin MB Oldstone (2000) ArticleTitleMyelin-associated oligodendrocytic basic protein: identification of an encephalitogenic epitope and association with multiple sclerosis J Immunol 164 1103–1109 Occurrence Handle10623862 Occurrence Handle1:CAS:528:DC%2BD3cXlt1Cqtg%3D%3D

    PubMed  CAS  Google Scholar 

  • A Holz N Schaeren-Wiemers C Schaefer U Pott RJ Colello ME Schwab (1996) ArticleTitleMolecular and developmental characterization of novel cDNAs of the myelin-associated/oligodendrocytic basic protein J Neurosci 16 467–477 Occurrence Handle8551331 Occurrence Handle1:CAS:528:DyaK28XksFKnuw%3D%3D

    PubMed  CAS  Google Scholar 

  • RA Hughes DR Cornblath (2005) ArticleTitleGuillain-Barre syndrome Lancet 366 1653–1666 Occurrence Handle16271648 Occurrence Handle1:CAS:528:DC%2BD2MXhtFOhu7%2FP

    PubMed  CAS  Google Scholar 

  • RA Hughes RD Hadden NA Gregson KJ Smith (1999) ArticleTitlePathogenesis of Guillain-Barre syndrome J Neuroimmunol 100 74–97 Occurrence Handle10695718 Occurrence Handle1:CAS:528:DC%2BD3cXltVeiug%3D%3D

    PubMed  CAS  Google Scholar 

  • DJ Hunter R Macmaster AW Roszak A Riboldi-Tunnicliffe IR Griffiths AA Freer (2005) ArticleTitleStructure of myelin P2 protein from equine spinal cord Acta Crystallogr D Biol Crystallogr 61 1067–1071 Occurrence Handle16041071

    PubMed  Google Scholar 

  • A Iglesias J Bauer T Litzenburger A Schubart C Linington (2001) ArticleTitleT- and B-cell responses to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis and multiple sclerosis Glia 36 220–234 Occurrence Handle11596130 Occurrence Handle1:STN:280:DC%2BD3MrkvVyksA%3D%3D

    PubMed  CAS  Google Scholar 

  • H Inouye DA Kirschner (1984) ArticleTitleEffects of ZnCl2 on membrane interactions in myelin of normal and shiverer mice Biochim Biophys Acta 776 197–208 Occurrence Handle6206893 Occurrence Handle1:CAS:528:DyaL2cXmtVyjsL0%3D

    PubMed  CAS  Google Scholar 

  • H Inouye H Tsuruta J Sedzik K Uyemura DA Kirschner (1999) ArticleTitleTetrameric assembly of full-sequence protein zero myelin glycoprotein by synchrotron X-ray scattering Biophys J 76 423–437 Occurrence Handle9876154 Occurrence Handle1:CAS:528:DyaK1MXjsFyktg%3D%3D

    PubMed  CAS  Google Scholar 

  • ML Jaramillo DE Afar G Almazan JC Bell (1994) ArticleTitleIdentification of tyrosine 620 as the major phosphorylation site of myelin-associated glycoprotein and its implication in interacting with signaling molecules J Biol Chem 269 27240–27245 Occurrence Handle7525550 Occurrence Handle1:CAS:528:DyaK2cXmt1Cmtbw%3D

    PubMed  CAS  Google Scholar 

  • TA Jones T Bergfors J Sedzik T Unge (1988) ArticleTitleThe three-dimensional structure of P2 myelin protein EMBO J 7 1597–1604 Occurrence Handle2458918 Occurrence Handle1:CAS:528:DyaL1cXktlCisbc%3D

    PubMed  CAS  Google Scholar 

  • JF Kaye N Kerlero de Rosbo I Mendel S Flechter M Hoffman I Yust A Ben-Nun (2000) ArticleTitleThe central nervous system-specific myelin oligodendrocytic basic protein (MOBP) is encephalitogenic and a potential target antigen in multiple sclerosis (MS) J Neuroimmunol 102 189–198 Occurrence Handle10636488 Occurrence Handle1:CAS:528:DyaK1MXotVKqtL0%3D

    PubMed  CAS  Google Scholar 

  • LA Kelley RM MacCallum MJ Sternberg (2000) ArticleTitleEnhanced genome annotation using structural profiles in the program 3D-PSSM J Mol Biol 299 499–520 Occurrence Handle10860755 Occurrence Handle1:CAS:528:DC%2BD3cXktVKlsL4%3D

    PubMed  CAS  Google Scholar 

  • K Kijima C Numakura E Shirahata Y Sawaishi M Shimohata S Igarashi T Tanaka K Hayasaka (2004) ArticleTitlePeriaxin mutation causes early-onset but slow-progressive Charcot-Marie-Tooth disease J Hum Genet 49 376–379 Occurrence Handle15197604

    PubMed  Google Scholar 

  • F Kirchhoff HW Hofer M Schachner (1993) ArticleTitleMyelin-associated glycoprotein is phosphorylated by protein kinase C J Neurosci Res 36 368–381 Occurrence Handle7505837 Occurrence Handle1:CAS:528:DyaK2cXivVShtQ%3D%3D

    PubMed  CAS  Google Scholar 

  • G Kozlov J Lee D Elias M Gravel P Gutierrez I Ekiel PE Braun K Gehring (2003) ArticleTitleStructural evidence that brain cyclic nucleotide phosphodiesterase is a member of the 2H phosphodiesterase superfamily J Biol Chem 278 46021–46028 Occurrence Handle12947117 Occurrence Handle1:CAS:528:DC%2BD3sXosl2itbo%3D

    PubMed  CAS  Google Scholar 

  • P Kraulis (1991) ArticleTitleMOLSCRIPT: a program to produce both detailed and schematic plots of protein structures J Appl Cryst 24 946–950

    Google Scholar 

  • P Kursula (2000) Cytoplasmic domains of the myelin-associated glycoprotein. Acta Univ Oul, D594 Oulu University Press Oulu, Finland

    Google Scholar 

  • P Kursula (2001) ArticleTitleThe current status of structural studies on proteins of the myelin sheath (Review) Int J Mol Med 8 475–479 Occurrence Handle11605013 Occurrence Handle1:CAS:528:DC%2BD3MXotlymsr8%3D

    PubMed  CAS  Google Scholar 

  • P Kursula (2003) ArticleTitleInsights into the structure and function of the myelin-associated glycoprotein Rec Res Dev Neurochem 6 65–80 Occurrence Handle1:CAS:528:DC%2BD2MXisVKiuw%3D%3D

    CAS  Google Scholar 

  • P Kursula VP Lehto AM Heape (2000) ArticleTitleS100beta inhibits the phosphorylation of the L-MAG cytoplasmic domain by PKA Brain Res Mol Brain Res 76 407–410 Occurrence Handle10762718 Occurrence Handle1:CAS:528:DC%2BD3cXitlOltr0%3D

    PubMed  CAS  Google Scholar 

  • P Kursula VP Lehto AM Heape (2001) ArticleTitleThe small myelin-associated glycoprotein binds to tubulin and microtubules Brain Res Mol Brain Res 87 22–30 Occurrence Handle11223156 Occurrence Handle1:CAS:528:DC%2BD3MXht12nsLk%3D

    PubMed  CAS  Google Scholar 

  • P Kursula G Merilainen VP Lehto AM Heape (1999a) ArticleTitleThe small myelin-associated glycoprotein is a zinc-binding protein J Neurochem 73 2110–2118 Occurrence Handle1:CAS:528:DyaK1MXntVWit74%3D

    CAS  Google Scholar 

  • P Kursula G Tikkanen VP Lehto M Nishikimi AM Heape (1999b) ArticleTitleCalcium-dependent interaction between the large myelin-associated glycoprotein and S100beta J Neurochem 73 1724–1732 Occurrence Handle1:CAS:528:DyaK1MXmtlOhtrs%3D

    CAS  Google Scholar 

  • C Lai JB Watson FE Bloom JG Sutcliffe RJ Milner (1987) ArticleTitleNeural protein 1B236/myelin-associated glycoprotein (MAG) defines a subgroup of the immunoglobulin superfamily Immunol Rev 100 129–151 Occurrence Handle2450062 Occurrence Handle1:CAS:528:DyaL1cXntlejtA%3D%3D

    PubMed  CAS  Google Scholar 

  • DS Libich CM Hill JD Haines G Harauz (2003) ArticleTitleMyelin basic protein has multiple calmodulin-binding sites Biochem Biophys Res Commun 308 313–319 Occurrence Handle12901870 Occurrence Handle1:CAS:528:DC%2BD3sXlvFGhu74%3D

    PubMed  CAS  Google Scholar 

  • JA Maatta MS Kaldman S Sakoda AA Salmi AE Hinkkanen (1998) ArticleTitleEncephalitogenicity of myelin-associated oligodendrocytic basic protein and 2′,3′-cyclic nucleotide 3′-phosphodiesterase for BALB/c and SJL mice Immunology 95 383–388 Occurrence Handle9824501 Occurrence Handle1:CAS:528:DyaK1cXnsVyjt74%3D

    PubMed  CAS  Google Scholar 

  • R Martini M Schachner (1986) ArticleTitleImmunoelectron microscopic localization of neural cell adhesion molecules (L1, N-CAM, and MAG) and their shared carbohydrate epitope and myelin basic protein in developing sciatic nerve J Cell Biol 103 2439–2448 Occurrence Handle2430983 Occurrence Handle1:CAS:528:DyaL2sXmsVyhsA%3D%3D

    PubMed  CAS  Google Scholar 

  • M Mata DJ Fink (1988) ArticleTitleCalmodulin distribution in peripheral nerve: an EM immunocytochemical study Brain Res 475 297–304 Occurrence Handle3214737 Occurrence Handle1:STN:280:DyaL1M7gsFOqtg%3D%3D

    PubMed  CAS  Google Scholar 

  • AP May RC Robinson M Vinson PR Crocker EY Jones (1998) ArticleTitleCrystal structure of the N-terminal domain of sialoadhesin in complex with 3′ sialyllactose at 1.85 Å resolution Mol Cell 1 719–728 Occurrence Handle9660955 Occurrence Handle1:CAS:528:DyaK1cXivF2msr0%3D

    PubMed  CAS  Google Scholar 

  • R Mazumder LM Iyer S Vasudevan L Aravind (2002) ArticleTitleDetection of novel members, structure-function analysis and evolutionary classification of the 2H phosphoesterase superfamily Nucleic Acids Res 30 5229–5243 Occurrence Handle12466548 Occurrence Handle1:CAS:528:DC%2BD38XptlOiurs%3D

    PubMed  CAS  Google Scholar 

  • AS McCallion GJ Stewart P Montague IR Griffiths RW Davies (1999) ArticleTitleSplicing pattern, transcript start distribution, and DNA sequence of the mouse gene (Mobp) encoding myelin-associated oligodendrocytic basic protein Mol Cell Neurosci 13 229–236 Occurrence Handle10328883 Occurrence Handle1:CAS:528:DyaK1MXivFOktLg%3D

    PubMed  CAS  Google Scholar 

  • HW Muller (1982) ArticleTitleDissociation of CNPase dimer into catalytically active monomers by 1,4-dithiothreitol and urea. Protein-promoted reassembly FEBS Lett 144 77–80 Occurrence Handle6286358 Occurrence Handle1:STN:280:DyaL383mt1Whtg%3D%3D

    PubMed  CAS  Google Scholar 

  • HW Muller PA Clapshaw W Seifert (1981) ArticleTitleTwo molecular forms of the isolated brain enzyme 2′,3′-cyclic nucleotide 3′-phosphodiesterase FEBS Lett 131 37–40 Occurrence Handle6269898 Occurrence Handle1:STN:280:DyaL38%2Fislyisg%3D%3D

    PubMed  CAS  Google Scholar 

  • A Niemann P Berger U Suter (2006) ArticleTitlePathomechanisms of mutant proteins in Charcot-Marie-Tooth disease Neuromol Med 8 217–242 Occurrence Handle1:CAS:528:DC%2BD28XksFantr8%3D

    CAS  Google Scholar 

  • C Ostermeier AT Brunger (1999) ArticleTitleStructural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A Cell 96 363–374 Occurrence Handle10025402 Occurrence Handle1:CAS:528:DyaK1MXht1eqs7w%3D

    PubMed  CAS  Google Scholar 

  • L Pedraza GC Owens LA Green JL Salzer (1990) ArticleTitleThe myelin-associated glycoproteins: membrane disposition, evidence of a novel disulfide linkage between immunoglobulin-like domains, and posttranslational palmitylation J Cell Biol 111 2651–2661 Occurrence Handle1703542 Occurrence Handle1:CAS:528:DyaK3cXmtVOjsrY%3D

    PubMed  CAS  Google Scholar 

  • E Polverini JM Boggs IR Bates G Harauz P Cavatorta (2004) ArticleTitleElectron paramagnetic resonance spectroscopy and molecular modelling of the interaction of myelin basic protein (MBP) with calmodulin (CaM)-diversity and conformational adaptability of MBP CaM-targets J Struct Biol 148 353–369 Occurrence Handle15522783 Occurrence Handle1:CAS:528:DC%2BD2cXpt1Squro%3D

    PubMed  CAS  Google Scholar 

  • RH Quarles JL Everly RO Brady (1973) ArticleTitleMyelin-associated glycoprotein: a developmental change Brain Res 58 506–509 Occurrence Handle4756140 Occurrence Handle1:CAS:528:DyaE2cXisFaktg%3D%3D

    PubMed  CAS  Google Scholar 

  • P Riccio S Giovannelli A Bobba E Romito A Fasano T Bleve-Zacheo R Favilla E Quagliariello P Cavatorta (1995) ArticleTitleSpecificity of zinc binding to myelin basic protein Neurochem Res 20 1107–1113 Occurrence Handle8570016 Occurrence Handle1:CAS:528:DyaK2MXosFyntb0%3D

    PubMed  CAS  Google Scholar 

  • RA Ridsdale DR Beniac TA Tompkins MA Moscarello G Harauz (1997) ArticleTitleThree-dimensional structure of myelin basic protein. II. Molecular modeling and considerations of predicted structures in multiple sclerosis J Biol Chem 272 4269–4275 Occurrence Handle9020143 Occurrence Handle1:CAS:528:DyaK2sXht1OktLw%3D

    PubMed  CAS  Google Scholar 

  • AM Rostami (1997) ArticleTitleP2-reactive T cells in inflammatory demyelination of the peripheral nerve J Infect Dis 176 IssueIDSuppl 2 S160–S163 Occurrence Handle9396703

    PubMed  Google Scholar 

  • Y Sakamoto K Kitamura K Yoshimura T Nishijima K Uyemura (1987) ArticleTitleComplete amino acid sequence of PO protein in bovine peripheral nerve myelin J Biol Chem 262 4208–4214 Occurrence Handle2435734 Occurrence Handle1:CAS:528:DyaL2sXkvFaiuro%3D

    PubMed  CAS  Google Scholar 

  • Y Sakamoto N Tanaka T Ichimiya T Kurihara KT Nakamura (2005) ArticleTitleCrystal structure of the catalytic fragment of human brain 2′,3′-cyclic-nucleotide 3′-phosphodiesterase J Mol Biol 346 789–800 Occurrence Handle15713463 Occurrence Handle1:CAS:528:DC%2BD2MXhsVCitbk%3D

    PubMed  CAS  Google Scholar 

  • J Sedzik G Carlone A Fasano GM Liuzzi P Riccio (2003) ArticleTitleCrystals of P2 myelin protein in lipid-bound form J Struct Biol 142 292–300 Occurrence Handle12713957 Occurrence Handle1:CAS:528:DC%2BD3sXjtVKisLg%3D

    PubMed  CAS  Google Scholar 

  • J Sedzik DA Kirschner (1992) ArticleTitleIs myelin basic protein crystallizable? Neurochem Res 17 157–166 Occurrence Handle1371603 Occurrence Handle1:CAS:528:DyaK38XnvFygsA%3D%3D

    PubMed  CAS  Google Scholar 

  • L Shapiro JP Doyle P Hensley DR Colman WA Hendrickson (1996) ArticleTitleCrystal structure of the extracellular domain from P0, the major structural protein of peripheral nerve myelin Neuron 17 435–449 Occurrence Handle8816707 Occurrence Handle1:CAS:528:DyaK28XlvFansrw%3D

    PubMed  CAS  Google Scholar 

  • ME Shy (2004) ArticleTitleCharcot-Marie-Tooth disease: an update Curr Opin Neurol 17 579–585 Occurrence Handle15367862 Occurrence Handle1:CAS:528:DC%2BD2cXhtVWrsLjJ

    PubMed  CAS  Google Scholar 

  • ME Shy CA Gabel EC Vietorisz N Latov (1986) ArticleTitleCharacterization of oligosaccharides that bind to human anti-MAG antibodies and to the mouse monoclonal antibody HNK-1 J Neuroimmunol 12 291–298 Occurrence Handle2428831 Occurrence Handle1:CAS:528:DyaL28Xmt1Citb4%3D

    PubMed  CAS  Google Scholar 

  • ME Shy A Jani K Krajewski M Grandis RA Lewis J Li RR Shy J Balsamo J Lilien JY Garbern J Kamholz (2004) ArticleTitlePhenotypic clustering in MPZ mutations Brain 127 371–384 Occurrence Handle14711881

    PubMed  Google Scholar 

  • M Sospedra R Martin (2005) ArticleTitleImmunology of multiple sclerosis Annu Rev Immunol 23 683–747 Occurrence Handle15771584 Occurrence Handle1:CAS:528:DC%2BD2MXktFOju7w%3D

    PubMed  CAS  Google Scholar 

  • H Stenmark R Aasland BH Toh A D’Arrigo (1996) ArticleTitleEndosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger J Biol Chem 271 24048–24054 Occurrence Handle8798641 Occurrence Handle1:CAS:528:DyaK28XlvFSqtrc%3D

    PubMed  CAS  Google Scholar 

  • NH Sternberger RH Quarles Y Itoyama HD Webster (1979) ArticleTitleMyelin-associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing rat Proc Natl Acad Sci USA 76 1510–1514 Occurrence Handle375239 Occurrence Handle1:CAS:528:DyaE1MXhvVeqt74%3D

    PubMed  CAS  Google Scholar 

  • S Tang YJ Shen ME DeBellard G Mukhopadhyay JL Salzer PR Crocker MT Filbin (1997) ArticleTitleMyelin-associated glycoprotein interacts with neurons via a sialic acid binding site at ARG118 and a distinct neurite inhibition site J Cell Biol 138 1355–1366 Occurrence Handle9298990 Occurrence Handle1:CAS:528:DyaK2sXmt1yjsbs%3D

    PubMed  CAS  Google Scholar 

  • AJ Thompson MS Cronin DA Kirschner (2002) ArticleTitleMyelin protein zero exists as dimers and tetramers in native membranes of Xenopus laevis peripheral nerve J Neurosci Res 67 766–771 Occurrence Handle11891790 Occurrence Handle1:CAS:528:DC%2BD38XitFCgtrk%3D

    PubMed  CAS  Google Scholar 

  • BD Trapp SB Andrews A Wong M O’Connell JW Griffin (1989) ArticleTitleCo-localization of the myelin-associated glycoprotein and the microfilament components, F-actin and spectrin, in Schwann cells of myelinated nerve fibres J Neurocytol 18 47–60 Occurrence Handle2468742 Occurrence Handle1:CAS:528:DyaL1MXhslSls7g%3D

    PubMed  CAS  Google Scholar 

  • BD Trapp M Dubois-Dalcq RH Quarles (1984) ArticleTitleUltrastructural localization of P2 protein in actively myelinating rat Schwann cells J Neurochem 43 944–948 Occurrence Handle6206203 Occurrence Handle1:STN:280:DyaL2c3ptFCgtw%3D%3D

    PubMed  CAS  Google Scholar 

  • BD Trapp RH Quarles (1982) ArticleTitlePresence of the myelin-associated glycoprotein correlates with alterations in the periodicity of peripheral myelin J Cell Biol 92 877–882 Occurrence Handle6177705 Occurrence Handle1:CAS:528:DyaL38XhsVShtLc%3D

    PubMed  CAS  Google Scholar 

  • D Tsang YS Tsang WK Ho RN Wong (1997) ArticleTitleMyelin basic protein is a zinc-binding protein in brain: possible role in myelin compaction Neurochem Res 22 811–819 Occurrence Handle9232633 Occurrence Handle1:CAS:528:DyaK2sXksFyqsrg%3D

    PubMed  CAS  Google Scholar 

  • AG Tzakos P Kursula A Troganis V Theodorou T Tselios C Svarnas J Matsoukas V Apostolopoulos IP Gerothanassis (2005) ArticleTitleStructure and function of the myelin proteins: current status and perspectives in relation to multiple sclerosis Curr Med Chem 12 1569–1587 Occurrence Handle15974988 Occurrence Handle1:CAS:528:DC%2BD2MXkvF2qtrY%3D

    PubMed  CAS  Google Scholar 

  • K Uyemura K Yoshimura M Suzuki K Kitamura (1984) ArticleTitleLipid binding activities of the P2 protein in peripheral nerve myelin Neurochem Res 9 1509–1514 Occurrence Handle6083473 Occurrence Handle1:CAS:528:DyaL2MXit1eh

    PubMed  CAS  Google Scholar 

  • KI Varughese ZM Ruggeri R Celikel (2004) ArticleTitlePlatinum-induced space-group transformation in crystals of the platelet glycoprotein Ib alpha N-terminal domain Acta Crystallogr D Biol Crystallogr 60 405–411 Occurrence Handle14993663

    PubMed  Google Scholar 

  • H Voshol CW van Zuylen G Orberger JF Vliegenthart M Schachner (1996) ArticleTitleStructure of the HNK-1 carbohydrate epitope on bovine peripheral myelin glycoprotein P0 J Biol Chem 271 22957–22960 Occurrence Handle8798480 Occurrence Handle1:CAS:528:DyaK28XlvVCitLo%3D

    PubMed  CAS  Google Scholar 

  • P Vourc’h C Andres (2004) ArticleTitleOligodendrocyte myelin glycoprotein (OMgp): evolution, structure and function Brain Res Brain Res Rev 45 115–124 Occurrence Handle15145622 Occurrence Handle1:CAS:528:DC%2BD2cXktVClur4%3D

    PubMed  CAS  Google Scholar 

  • P Vourc’h S Dessay O Mbarek S Marouillat Vedrine JP Muh C Andres (2003a) ArticleTitleThe oligodendrocyte-myelin glycoprotein gene is highly expressed during the late stages of myelination in the rat central nervous system Brain Res Dev Brain Res 144 159–168 Occurrence Handle1:CAS:528:DC%2BD3sXmsVKgu7Y%3D

    CAS  Google Scholar 

  • P Vourc’h T Moreau F Arbion S Marouillat-Vedrine JP Muh C Andres (2003b) ArticleTitleOligodendrocyte myelin glycoprotein growth inhibition function requires its conserved leucine-rich repeat domain, not its glycosylphosphatidyl-inositol anchor J Neurochem 85 889–897 Occurrence Handle1:CAS:528:DC%2BD3sXktVGhur4%3D Occurrence Handle10.1046/j.1471-4159.2003.01764.x

    Article  CAS  Google Scholar 

  • LK Wang CD Lima S Shuman (2002) ArticleTitleStructure and mechanism of T4 polynucleotide kinase: an RNA repair enzyme EMBO J 21 3873–3880 Occurrence Handle12110598 Occurrence Handle1:CAS:528:DC%2BD38XlslOkurs%3D

    PubMed  CAS  Google Scholar 

  • N Watanabe S Wachi T Fujita (2003) ArticleTitleIdentification and characterization of BCL-3-binding protein: implications for transcription and DNA repair or recombination J Biol Chem 278 26102–26110 Occurrence Handle12730195 Occurrence Handle1:CAS:528:DC%2BD3sXlt1Clt7Y%3D

    PubMed  CAS  Google Scholar 

  • Y Yamamoto R Mizuno T Nishimura Y Ogawa H Yoshikawa H Fujimura E Adachi T Kishimoto T Yanagihara S Sakoda (1994) ArticleTitleCloning and expression of myelin-associated oligodendrocytic basic protein. A novel basic protein constituting the central nervous system myelin J Biol Chem 269 31725–31730 Occurrence Handle7989345 Occurrence Handle1:CAS:528:DyaK2MXitVSkt7s%3D

    PubMed  CAS  Google Scholar 

  • Y Yamamoto H Yoshikawa S Nagano G Kondoh S Sadahiro T Gotow T Yanagihara S Sakoda (1999) ArticleTitleMyelin-associated oligodendrocytic basic protein is essential for normal arrangement of the radial component in central nervous system myelin Eur J Neurosci 11 847–855 Occurrence Handle10103078 Occurrence Handle1:STN:280:DyaK1M3gtleisw%3D%3D

    PubMed  CAS  Google Scholar 

  • H Yoshikawa (2001) ArticleTitleMyelin-associated oligodendrocytic basic protein modulates the arrangement of radial growth of the axon and the radial component of myelin Med Electron Microsc 34 160–164 Occurrence Handle11793190 Occurrence Handle1:CAS:528:DC%2BD38XhtFShtbw%3D

    PubMed  CAS  Google Scholar 

  • A Zarrinpar RP Bhattacharyya WA Lim (2003) ArticleTitleThe structure and function of proline recognition domains Sci STKE 2003 RE8 Occurrence Handle12709533 Occurrence Handle10.1126/stke.2003.179.re8

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biochemistry, University of Oulu, Oulu, Finland

    P. Kursula

Authors
  1. P. Kursula
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Author’s address: Dr. Petri Kursula, Department of Biochemistry, University of Oulu, FIN-90014 Oulu, Finland

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kursula, P. Structural properties of proteins specific to the myelin sheath. Amino Acids 34, 175–185 (2008). https://doi.org/10.1007/s00726-006-0479-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00726-006-0479-7

Search

Navigation