Skip to main content

Advertisement

SpringerLink
Log in

The nuclear proteasome and the degradation of oxidatively damaged proteins

  • Review Article
  • Published:
Amino Acids Aims and scope Submit manuscript

Summary.

The accumulation of oxidized proteins is known to be linked to some severe neurodegenerative diseases like Alzheimer’s, Parkinson’s and Huntington’s disease. Furthermore, the aging process is also accompanied by an ongoing aggregation of misfolded and damaged proteins. Therefore, mammalian cells have developed potent degradation systems, which selectively degrade damaged and misfolded proteins. The proteasomal system is largely responsible for the removal of oxidatively damaged proteins form the cellular environment. Not only cytosolic proteins are prone to oxidative stress, also nuclear proteins are readily oxidized. The nuclear proteasomal system is responsible for the degradation of these proteins. This review is focused on the specific degradation of oxidized nuclear proteins, the role of the proteasome in this process and the regulation of the nuclear proteasomal system under oxidative conditions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

AD:

Alzheimer’s disease

ADP:

adenosinediphosphate

AGE:

advanced glycosilation end products

ATP:

adenosinetriphosphate

DNA:

desoxyribonucleic acid

EGF:

epidermal growth factor

ER:

endoplasmic reticulum

G6PD:

glucose-6-phosphate dehydrogenase

GAPDH:

glyceraldehyde-3-phosphate dehydrogenase

HD:

Huntington’s disease

HNE:

4-hydroxynonenal

IFγ:

interferon γ

MDA:

malondialdehyde

MHC-I:

major histocompatibility complex class I

NAD+ :

nicotinamide adenosine dinucleotide

NLS:

nuclear localization signal

pADPR:

poly-(ADP-ribose)

PARP:

poly-(ADP-ribose) polymerase

PD:

Parkinson’s disease

RNS:

reactive nitrogen species

ROS:

reactive oxygen species

References

  • M Aki N Shimbara M Takashina K Akiyama S Kagawa T Tamurea N Tanahashi T Yoshimura K Tanaka A Ichihara (1994) ArticleTitleInterferon-gamma induces different subunit organizations and functional diversity of proteasomes J Biochem 115 257–269 Occurrence Handle8206875 Occurrence Handle1:CAS:528:DyaK2cXhs1WgsbY%3D

    PubMed  CAS  Google Scholar 

  • J Arnold T Grune (2002) ArticleTitlePARP-mediated proteasome activation: a co-ordination of DNA repair and protein degradation? BioEssays 24 1060–1065 Occurrence Handle12386937 Occurrence Handle1:CAS:528:DC%2BD38XovFKlt7g%3D

    PubMed  CAS  Google Scholar 

  • M Bajorek MH Glickman (2004) ArticleTitleKeepers at the final gates: regulatory complexes and gating of the proteasomal channel Cell Mol Life Sci 61 1–10

    Google Scholar 

  • KJ Barnham CL Masters AI Bush (2004) ArticleTitleNeurodegenerative diseases and oxidative stress Nat Rev Drug Discov 3 205–214 Occurrence Handle15031734 Occurrence Handle1:CAS:528:DC%2BD2cXit12nsL4%3D

    PubMed  CAS  Google Scholar 

  • R Beedholm BFC Clark SIS Rattan (2004) ArticleTitleMild heat stress stimulates 20S proteasome and its 11S activator in human fibroblasts undergoing aging in vitro Cell Stress Chaperones 9 49–57 Occurrence Handle15270077 Occurrence Handle1:CAS:528:DC%2BD2cXjs1yjs70%3D

    PubMed  CAS  Google Scholar 

  • S Bose FL Stratford KI Broadfoot GG Mason AJ Rivett (2004) ArticleTitlePhosphorylation of 20S proteasome alpha subunit C8 (alpha7) stabilizes the 26S proteasome and plays a role in the regulation of proteasome complexes by gamma-interferon Biochem J 378 177–184 Occurrence Handle14583091 Occurrence Handle1:CAS:528:DC%2BD2cXitlSnsrY%3D

    PubMed  CAS  Google Scholar 

  • E Bossy-Wetzel R Schwarzenbacher SA Lipton (2004) ArticleTitleMolecular pathways to neurodegeneration Nat Med 10 S2–S9 Occurrence Handle15272266

    PubMed  Google Scholar 

  • BC Braun M Glickman R Kraft B Dahlmann PM Kloetzel D Finley M Schmidt (1999) ArticleTitleThe base of the proteasome regulatory particle exhibits chaperone-like activity Nature Cell Biol 1 221–226 Occurrence Handle10559920 Occurrence Handle1:CAS:528:DyaK1MXltlSjt78%3D

    PubMed  CAS  Google Scholar 

  • P Brooks G Fuertes RZ Murray S Bose E Knecht MC Rechsteiner KB Hendil K Tanaka J Dyson J Rivett (2000) ArticleTitleSubcellular localization fo proteasomes and their regulatory complexes in mammalian cells Biochem J 346 155–161 Occurrence Handle10657252 Occurrence Handle1:CAS:528:DC%2BD3cXhsF2isLw%3D

    PubMed  CAS  Google Scholar 

  • DP Buchczyk T Grune H Sies LO Klotz (2003) ArticleTitleModifications of glyceraldeyde-3-phosphate dehydrogenase induced by increasing concentrations of peroxynitrite: early recognition by 20S proteasome Biol Chem 384 237–241 Occurrence Handle12675516 Occurrence Handle1:CAS:528:DC%2BD3sXjt12rsrg%3D

    PubMed  CAS  Google Scholar 

  • G Carrard AL Bulteau I Petropoulos B Friguet (2002) ArticleTitleImpairment of proteasome structure and function in aging Int J Biochem Cell Biol 34 1461–1474 Occurrence Handle12200039 Occurrence Handle1:CAS:528:DC%2BD38XmsVertrw%3D

    PubMed  CAS  Google Scholar 

  • D Cervantes-Laurean MJ Roberts EL Jacobson MK Jacobson (2005) ArticleTitleNuclear proteasome activation and degradation of carboxymethylated histones in human keratinocytes following glyoxal treatment Free Radic Biol Med 38 786–795 Occurrence Handle15721989 Occurrence Handle1:CAS:528:DC%2BD2MXhsVyqtrg%3D

    PubMed  CAS  Google Scholar 

  • M Chu-Ping CA Slaughter GN DeMartino (1992) ArticleTitlePurification and characterization of a protein inhibitor of the 20S proteasome (macropain) Biochim Biophys Acta 1119 303–311 Occurrence Handle1312359 Occurrence Handle1:STN:280:By2C1M%2FisFQ%3D

    PubMed  CAS  Google Scholar 

  • A Ciechanover P Brundin (2003) ArticleTitleThe ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg Neuron 40 427–446 Occurrence Handle14556719 Occurrence Handle1:CAS:528:DC%2BD3sXosFCqs70%3D

    PubMed  CAS  Google Scholar 

  • S Claverol O Burlet-Schiltz E Girbal-Neuhauser JE Gairin B Monsarrat (2002) ArticleTitleMapping and structural dissection of human 20S proteasome using proteomic approaches Mol Cell Proteomics 1 567–578 Occurrence Handle12376572 Occurrence Handle1:CAS:528:DC%2BD38XotlCntL0%3D

    PubMed  CAS  Google Scholar 

  • O Coux K Tanaka AL Goldberg (1996) ArticleTitleStructure and function of the 20S and 26S proteasomes Annu Rev Biochem 65 801–847 Occurrence Handle8811196 Occurrence Handle1:CAS:528:DyaK28XktFamurc%3D

    PubMed  CAS  Google Scholar 

  • KJ Davies (2001) ArticleTitleDegradation of oxidized proteins by the 20S proteasome Biochimie 83 301–310 Occurrence Handle11295490 Occurrence Handle1:CAS:528:DC%2BD3MXivFKhu7s%3D

    PubMed  CAS  Google Scholar 

  • M Demasi GM Silva LE Netto (2003) ArticleTitle20S proteasome from Saccharomyces cerevisiae is responsive to redox modifications and is S-glutathionylated J Biol Chem 378 679–685

    Google Scholar 

  • J Emerit M Edeas F Bricaire (2004) ArticleTitleNeurodegenerative diseases and oxidative stress Biomed Pharmacother 58 39–46 Occurrence Handle14739060 Occurrence Handle1:CAS:528:DC%2BD2cXltVKmtw%3D%3D

    PubMed  CAS  Google Scholar 

  • C Enenkel A Lehmann PM Kloetzel (1998) ArticleTitleSubcellular distribution of proteasomes implicates a major location of protein degradation in the nuclear envelope-ER network in yeast EMBO J 17 6144–6154 Occurrence Handle9799224 Occurrence Handle1:CAS:528:DyaK1cXnsVKhtrg%3D

    PubMed  CAS  Google Scholar 

  • AL Evdonin NV Tsupkina IM Konstantinova ND Medvedeva (2001) ArticleTitleEffect of EGF on nuclear-cytoplasmic distribution of proteasomes in A-431 cells Tsitologiia 43 142–147 Occurrence Handle11347469 Occurrence Handle1:CAS:528:DC%2BD3MXjtVCqtL4%3D

    PubMed  CAS  Google Scholar 

  • G Fenteany RF Standaert WS Lane S Choi EJ Corey SL Schreiber (1995) ArticleTitleInhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin Science 268 726–731 Occurrence Handle7732382 Occurrence Handle1:CAS:528:DyaK2MXlsVGitrg%3D

    PubMed  CAS  Google Scholar 

  • B Friguet ER Stadtman LI Szweda (1994a) ArticleTitleModification of glucose-6-phosphate dehydrogenase by 4-hydroxy-2-nonenal. Formation of cross-linked protein that inhibits the multicatalytic protease J Biol Chem 269 21639–21643 Occurrence Handle1:CAS:528:DyaK2cXlslKisrc%3D

    CAS  Google Scholar 

  • B Friguet LI Szweda ER Stadtman (1994b) ArticleTitleSusceptibility of glucose-6-phosphat dehydrogenase modified by 4-hydroxy-2-nonenal and metal-catalyzed oxidation to proteolysis by the multicatalytic protease Arch Biochem Biophys 311 168–173 Occurrence Handle1:CAS:528:DyaK2cXltVakt78%3D

    CAS  Google Scholar 

  • J Gieche J Mehlhase A Licht T Zacke N Sitte T Grune (2001) ArticleTitleProtein oxidation and proteolysis in RAW264.7 macrophages: effects of PMA activation Biochim Biophys Acta 1538 321–328 Occurrence Handle11336803 Occurrence Handle1:CAS:528:DC%2BD3MXivFeht7g%3D

    PubMed  CAS  Google Scholar 

  • C Giulivi RE Pacifici KJA Davies (1994) ArticleTitleExposure of hydrophobic moieties promotes the selective degradation of hydrogen peroxide-modified hemoglobin by the multicatalytic proteinase complex, proteasome Arch Biochem Biophys 311 329–341 Occurrence Handle8203895 Occurrence Handle1:CAS:528:DyaK2cXksFGjtro%3D

    PubMed  CAS  Google Scholar 

  • MH Glickman V Maytal (2002) Regulating the 26S proteasome P Zwickl W Baumeister (Eds) The proteasome-ubiquitin protein degradation pathway Springer Berlin Heidelberg 43–62

    Google Scholar 

  • AL Goldberg (2003) ArticleTitleProtein degradation and protection against misfolded or damaged proteins Nature 426 895–899 Occurrence Handle14685250 Occurrence Handle1:CAS:528:DC%2BD3sXpvVGmtbc%3D

    PubMed  CAS  Google Scholar 

  • M Groll I Ditzel J Löwe D Stock M Bochtler HD Bartunik R Huber (1997) ArticleTitleStructure of 20S proteasome form yeast at 2.4 Å resolution Nature 386 463–471 Occurrence Handle9087403 Occurrence Handle1:CAS:528:DyaK2sXisVSqsr0%3D

    PubMed  CAS  Google Scholar 

  • M Groll KB Kim N Kairies R Huber CM Crews (2000) ArticleTitleCrystal structure of epoxymicin: 20S proteasome reveals a molecular basis for selectivity of α′,β′-epoxyketone proteasomal inhibitors J Am Chem Soc 122 1237–1238 Occurrence Handle1:CAS:528:DC%2BD3cXms1WntQ%3D%3D

    CAS  Google Scholar 

  • T Grune (2003) ArticleTitleProtein oxidation in the aging of skin fibroblasts Hautarzt 54 818–821 Occurrence Handle12955257 Occurrence Handle1:STN:280:DC%2BD3svhsFCjug%3D%3D

    PubMed  CAS  Google Scholar 

  • T Grune IE Blasig N Sitte B Roloff R Haseloff KJ Davies (1998) ArticleTitlePeroxynitrite increases the degradation of aconitase and other cellular proteins by proteasome J Biol Chem 273 10857–10862 Occurrence Handle9556559 Occurrence Handle1:CAS:528:DyaK1cXjtFGktrg%3D

    PubMed  CAS  Google Scholar 

  • T Grune KJ Davies (2003) ArticleTitleThe proteasomal system and HNE-modified proteins Mol Aspects Med 24 195–204 Occurrence Handle12892997 Occurrence Handle1:CAS:528:DC%2BD3sXlvVClsL0%3D

    PubMed  CAS  Google Scholar 

  • T Grune LO Klotz J Gieche M Rudeck H Sies (2001) ArticleTitleProtein oxidation and proteolysis by the nonradical oxidants singlet oxygen or peroxynitrite Free Radic Biol Med 30 1243–1253 Occurrence Handle11368922 Occurrence Handle1:CAS:528:DC%2BD3MXjsFegtL4%3D

    PubMed  CAS  Google Scholar 

  • T Grune T Reinheckel KJ Davies (1996) ArticleTitleDegradation of oxidized proteins in K562 human hematopoietic cells by proteasome J Biol Chem 271 15504–15509 Occurrence Handle8663134 Occurrence Handle1:CAS:528:DyaK28XjvFWiurc%3D

    PubMed  CAS  Google Scholar 

  • T Grune T Reinheckel M Joshi KJ Davies (1995) ArticleTitleProteolysis in cultured liver epithelial cells during oxidative stress. Role of the multicatalytic proteinase complex, proteasome J Biol Chem 270 2344–2351 Occurrence Handle7836468 Occurrence Handle1:CAS:528:DyaK2MXjsV2kt7Y%3D

    PubMed  CAS  Google Scholar 

  • T Grune T Reinheckel R Li JA North KJ Davies (2002) ArticleTitleProteasome-dependent turnover of protein disulfide isomerase in oxidatively stressed cells Arch Biochem Biophys 397 407–413 Occurrence Handle11795901 Occurrence Handle1:CAS:528:DC%2BD38XktlyksA%3D%3D

    PubMed  CAS  Google Scholar 

  • JW Harper JC Powers (1985) ArticleTitleReaction of serine proteases with substituted 3-alkoxy-4-chloroisocoumarins and 3-alkoxy-7-amino-4-chloroisocoumarins: new reactive mechanism-based inhibitors Biochemistry 25 7200–7213

    Google Scholar 

  • CP Hill EI MAsters FG Whitby (2002) The 11S regulators of 20S proteasome activity P Zwickl W Baumeister (Eds) The proteasome-ubiquitin protein degradation pathway Springer Berlin Heidelberg 73–90

    Google Scholar 

  • S Kanno A Shouji R Hirata K Asou M Ishikawa (2004) ArticleTitleEffects of naringin on cytosine arabinoside (Ara-C)-induced cytotoxicity and apoptosis in P388 cells Life Sci 75 353–365 Occurrence Handle15135655 Occurrence Handle1:CAS:528:DC%2BD2cXjvVagsLg%3D

    PubMed  CAS  Google Scholar 

  • JN Keller FA Schmidt SW Scheff Q Ding DA Butterfield WR Markesberry (2005) ArticleTitleEvidence of increased oxidative damage in subjects with mild cognitive impairment Neurology 64 1152–1156 Occurrence Handle15824339 Occurrence Handle1:CAS:528:DC%2BD2MXislSmu7k%3D

    PubMed  CAS  Google Scholar 

  • M Khan S Varadharaj JC Shobha MU Naidu NL Parinandi VK Kutala P Kuppusamy (2006) ArticleTitleC-phycocyanin ameliorates doxorubicin-induced oxidative stress and apoptosis in adult rat cardiomyocytes J Cardiovasc Pharmacol 47 9–20 Occurrence Handle16424780 Occurrence Handle1:CAS:528:DC%2BD28Xls1Gntw%3D%3D

    PubMed  CAS  Google Scholar 

  • HD Kim A Tomida Y Ogiso T Tsuruo (1999) ArticleTitleGlucose-regulated stresses cause degeneration of DNA topoisomerase IIalpha by inducing nuclear proteasome during G1 cell cycle arrest in cancer cells J Cell Physiol 180 97–104 Occurrence Handle10362022 Occurrence Handle1:CAS:528:DyaK1MXjs1CgsLY%3D

    PubMed  CAS  Google Scholar 

  • U Klein M Gernold PM Kloetzel (1990) ArticleTitleCell-specific accumulation of Drosophila proteasomes (MCP) during early development J Cell Biol 111 2275–2282 Occurrence Handle2126012 Occurrence Handle1:CAS:528:DyaK3cXmtVylsb8%3D

    PubMed  CAS  Google Scholar 

  • C Knuehl A Seelig B Brecht P Henklein PM Kloetzel (1996) ArticleTitleFunctional analysis of eukayotic 20S proteasome nuclear localization signal Exp Cell Res 225 67–74 Occurrence Handle8635518 Occurrence Handle1:CAS:528:DyaK28XjtFOqtrs%3D

    PubMed  CAS  Google Scholar 

  • J Kohno Y Koguchi M Niskio K Nakao M Kuroda R Shimizu T Ohnuki S Komatsubara (2000) ArticleTitleStructures of TMC-95A-D: novel proteasome inhibitors from Apoispore montagnei Sacc. TC 1093 J Org Chem 65 990–995 Occurrence Handle10814045 Occurrence Handle1:CAS:528:DC%2BD3cXotlOnuw%3D%3D

    PubMed  CAS  Google Scholar 

  • E Kruger PM Kloetzel C Enenkel (2001) ArticleTitle20S proteasome biogenesis Biochimie 83 289–293 Occurrence Handle11295488 Occurrence Handle1:CAS:528:DC%2BD3MXivFKhu70%3D

    PubMed  CAS  Google Scholar 

  • P Lasch T Petras O Ullrich J Backmann D Naumann T Grune (2001) ArticleTitleHydrogen peroxide-induced structural alterations of RNAse A J Biol Chem 276 9492–9502 Occurrence Handle11115501 Occurrence Handle1:CAS:528:DC%2BD3MXisVCmsbk%3D

    PubMed  CAS  Google Scholar 

  • DH Lee AL Goldberg (1996) ArticleTitleSelective inhibitors of the proteasome-dependent and vacuolar pathways of protein degradation in Saccharomyces cerevisiae J Biol Chem 271 27280–27284 Occurrence Handle8910302 Occurrence Handle1:CAS:528:DyaK28XmvVWms78%3D

    PubMed  CAS  Google Scholar 

  • A Lehmann K Janek B Braun PM Kloetzel C Enenkel (2002) ArticleTitle20S proteasomes are imported as precursor complex into the nucleus of yeast J Mol Biol 317 401–413 Occurrence Handle11922673 Occurrence Handle1:CAS:528:DC%2BD38XitlGntrc%3D

    PubMed  CAS  Google Scholar 

  • XS Li JD Etlinger (1992) ArticleTitleUbiquitinated proteasome inhibitor is a component of the 26S proteasome complex Biochemistry 31 11964–11967 Occurrence Handle1333790 Occurrence Handle1:STN:280:ByyD1M%2Fnt1A%3D

    PubMed  CAS  Google Scholar 

  • J Löwe D Stock B Jap P Zwickl W Baumeister R Huber (1995) ArticleTitleCrystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 Å resolution Science 268 533–539 Occurrence Handle7725097

    PubMed  Google Scholar 

  • P Mayer-Kuckuk O Ullrich M Ziegler T Grune M Schweiger (1999) ArticleTitleFunctional interaction of poly(ADP-ribose) with the 20S proteasome in vitro Biochem Biophys Res Commun 259 576–581 Occurrence Handle10364460 Occurrence Handle1:CAS:528:DyaK1MXjs1Gnuro%3D

    PubMed  CAS  Google Scholar 

  • J Mehlhase J Gieche O Ullrich N Sitte T Grune (2000) ArticleTitleLPS-induced protein oxidation and proteolysis in BV-2 microglial cells IUBMB Life 50 1–5

    Google Scholar 

  • J Mehlhase G Sandig K Pantopoulos T Grune (2005) ArticleTitleOxidation-induced ferritin turnover in microglial cells: role of the proteasome Free Radic Biol Med 38 276–285 Occurrence Handle15607911 Occurrence Handle1:CAS:528:DC%2BD2cXhtVyqsb%2FO

    PubMed  CAS  Google Scholar 

  • K Merker N Sitte T Grune (2000) ArticleTitleHydrogen peroxide-mediated protein oxidation in young and old human MRC-5 fibroblasts Arch Biochem Biophys 375 50–54 Occurrence Handle10683247 Occurrence Handle1:CAS:528:DC%2BD3cXht1Sgsbo%3D

    PubMed  CAS  Google Scholar 

  • K Merker O Ullrich H Schmidt N Sitte T Grune (2003) ArticleTitleStability of the nuclear protein turnover during cellular senescence of human fibroblasts FASEB J 17 1963–1965 Occurrence Handle12897070 Occurrence Handle1:CAS:528:DC%2BD3sXot1KitLo%3D

    PubMed  CAS  Google Scholar 

  • Y Ogiso A Tomida HD Kim T Tsuruo (1999) ArticleTitleGlucose starvation and hypoxia induce nuclear accumulation of proteasome in cancer cells Biochem Biophys Res Commun 258 448–452 Occurrence Handle10329407 Occurrence Handle1:CAS:528:DyaK1MXjtVert7c%3D

    PubMed  CAS  Google Scholar 

  • Y Ogiso A Tomida T Tsuruo (2002) ArticleTitleNuclear localization of proteasomes participates in stress-inducible resistance of solid tumor cells to topoisomerase II-directed drugs Cancer Res 62 5008–5012 Occurrence Handle12208754 Occurrence Handle1:CAS:528:DC%2BD38Xmslyksro%3D

    PubMed  CAS  Google Scholar 

  • RE Pacifici Y Kono KJA Davies (1993) ArticleTitleHydrophobicity as the signal for selective degradation of hydroxyl radical-modified hemoglobin by the multicatalytic proteinase complex, proteasome J Biol Chem 268 15405–15411 Occurrence Handle8393440 Occurrence Handle1:CAS:528:DyaK3sXlvFygs78%3D

    PubMed  CAS  Google Scholar 

  • JT Palmer D Rasnick JL Klaus D Bromme (1995) ArticleTitleVinyl sulfones as mechanism-based cysteine protease inhibitores J Med Chem 38 3193–3196 Occurrence Handle7650671 Occurrence Handle1:CAS:528:DyaK2MXnt1Kltbc%3D

    PubMed  CAS  Google Scholar 

  • J-M Peters WW Franke JA Kleinschmidt (1994) ArticleTitleDistinct 19S and 20S subcomplexes of the 26S proteasome and their distribution in the nucleus and the cytoplasm J Biol Chem 269 7709–7718 Occurrence Handle8125997 Occurrence Handle1:CAS:528:DyaK2cXjtFOrt7w%3D

    PubMed  CAS  Google Scholar 

  • M Rechsteiner C Realini V Ustrell (2000) ArticleTitleTeh proteasome activator 11S REG (PA28) and class I antigen presentation Biochem J 345 1–15 Occurrence Handle10600633 Occurrence Handle1:CAS:528:DC%2BD3cXot1KntA%3D%3D

    PubMed  CAS  Google Scholar 

  • T Reinheckel Sitte O Ullrich U Kuckelkorn KJ Davies T Grune (1998) ArticleTitleComparative resistance of the 20S and 26S proteasome to oxidative stress Biochem J 335 637–642 Occurrence Handle9794805 Occurrence Handle1:CAS:528:DyaK1cXnsFersrs%3D

    PubMed  CAS  Google Scholar 

  • T Reinheckel O Ullrich N Sitte T Grune (2000) ArticleTitleDifferential impairment of 20S and 26S proteasome activities in human hematopoietic K562 cells during oxidative stress Arch Biochem Biophys 377 65–68 Occurrence Handle10775442 Occurrence Handle1:CAS:528:DC%2BD3cXisF2isL4%3D

    PubMed  CAS  Google Scholar 

  • EA Reits AM Benham B Plougastel J Neefjes J Trowsdale (1997) ArticleTitleDynamics of proteasome distribution in living cells EMBO J 16 6087–6094 Occurrence Handle9321388 Occurrence Handle1:CAS:528:DyaK2sXnt1art7o%3D

    PubMed  CAS  Google Scholar 

  • AJ Rivett (1998) ArticleTitleIntracellular distribution of proteasomes Curr Opin Immunol 10 110–114 Occurrence Handle9523120 Occurrence Handle1:CAS:528:DyaK1cXhvVahtLg%3D

    PubMed  CAS  Google Scholar 

  • Y Saitoh H Yokosawa S Ishii (1989) ArticleTitleSodium Dodecyl sulfate-induced conformational and enzymatic changes of multicatalytic proteinase Biochem Biophys Res Commun 162 334–339 Occurrence Handle2751656 Occurrence Handle1:CAS:528:DyaL1MXksleksrk%3D

    PubMed  CAS  Google Scholar 

  • DC Salo SW Lin RE Pacifici KJ Davies (1988) ArticleTitleSuperoxide dismutase is preferentially degraded by a proteolytic system from red blood cells following oxidative modification by hydrogen peroxide Free Radic Biol Med 5 335–339 Occurrence Handle2476367 Occurrence Handle1:CAS:528:DyaL1MXntFKktg%3D%3D

    PubMed  CAS  Google Scholar 

  • DC Salo RE Pacifici SW Lin C Giulivi KJ Davies (1990) ArticleTitleSuperoxide dismutase undergoes proteolysis and fragmentation following oxidative modification and inactivation J Biol Chem 265 11919–11927 Occurrence Handle2195028 Occurrence Handle1:CAS:528:DyaK3cXlt1Orsro%3D

    PubMed  CAS  Google Scholar 

  • PJ Savory H Djaballah H Angliker E Shaw AJ Rivett (1993) ArticleTitleReaction of proteasomes with peptidylchloromethanes and peptidyldiazomethanes Biochem J 296 601–605 Occurrence Handle8280057 Occurrence Handle1:CAS:528:DyaK2cXkvVOntA%3D%3D

    PubMed  CAS  Google Scholar 

  • M Seeger K Ferrell R Frank W Dubiel (1997) ArticleTitleHIV-1 tat inhibits the 20S proteasome and its 11S regulator-mediated activation J Biol Chem 272 8145–8148 Occurrence Handle9079628 Occurrence Handle1:CAS:528:DyaK2sXitF2itrY%3D

    PubMed  CAS  Google Scholar 

  • R Shringarpure T Grune J Mehlhase KJ Davies (2003) ArticleTitleUbiquitin conjugation is not required for the degradation of oxidized proteins by proteasome J Biol Chem 278 311–318 Occurrence Handle12401807 Occurrence Handle1:CAS:528:DC%2BD38XpvVWgtb4%3D

    PubMed  CAS  Google Scholar 

  • R Shringarpure T Grune N Sitte KJ Davies (2000) ArticleTitle4-Hydroxynonenal-modified amyloid-beta peptide ihibits the proteasome: possible importance in Alzheimer’s disease Cell Mol Life Sci 57 1802–1809 Occurrence Handle11130184 Occurrence Handle1:CAS:528:DC%2BD3MXhsFKgtQ%3D%3D

    PubMed  CAS  Google Scholar 

  • N Sitte K Merker T Grune (1998) ArticleTitleProteasome-dependent degradation of oxidized proteins in MRC-5 fibroblasts FEBS Lett 440 399–402 Occurrence Handle9872410 Occurrence Handle1:CAS:528:DyaK1cXnvVSqsL4%3D

    PubMed  CAS  Google Scholar 

  • N Sitte M Huber T Grune A Ladhoff WD Doecke T Zglinicki KJA Davies (2000a) ArticleTitleProteasome inhibition by lipofuscin/ceroid during postmitotic ageing of fibroblasts FASEB J 14 1490–1498 Occurrence Handle1:CAS:528:DC%2BD3cXlslaqtrk%3D

    CAS  Google Scholar 

  • N Sitte K Merker T von Zglinicki KJA Davies T Grune (2000b) ArticleTitleProtein oxidation and degradation during cellular senescence of human BJ-fibroblasts: Part I – Effects of proliferative senescence FASEB J 14 2495–2502 Occurrence Handle1:CAS:528:DC%2BD3MXht1SntL4%3D

    CAS  Google Scholar 

  • N Sitte K Merker T von Zglinicki KJA Davies T Grune (2000c) ArticleTitleProtein oxidation and degradation during cellular senescence of human BJ-fibroblasts: Part II – Aging of non-dividing cells FASEB J 14 2503–2510 Occurrence Handle1:CAS:528:DC%2BD3MXht1SntL8%3D

    CAS  Google Scholar 

  • O Sommerburg O Ullrich N Sitte D von Zglinicki W Siems T Grune (1998) ArticleTitleDose- and wavelength-dependent oxidation of crystallins by UV light – selective recognition and degradation by the 20S proteasome Free Radic Biol Med 24 1369–1374 Occurrence Handle9641254 Occurrence Handle1:CAS:528:DyaK1cXjvVGgur4%3D

    PubMed  CAS  Google Scholar 

  • C von Sonntag (1987) The chemical base of radiation oncology Taylor & Francis London 9

    Google Scholar 

  • A Spaltenstein JJ Leban JJ Huang KR Reinhardt OH Viveros J Sigafoos R Crouch (1996) ArticleTitleDesign and synthesis of novel protease inhibitors. Tripeptide α′,β′-epoxyketones as nanomolar inactivators of the proteasome Tetrahedron Lett 37 1343–1346 Occurrence Handle1:CAS:528:DyaK28XhsFWrtL8%3D

    CAS  Google Scholar 

  • PR Strack L Waxman JM Fagan (1996) ArticleTitleActivation of the multicatalytic endopeptidase by oxidants. Effects on enzyme structure Biochemistry 35 7142–7149 Occurrence Handle8679541 Occurrence Handle1:CAS:528:DyaK28XivFSmu7k%3D

    PubMed  CAS  Google Scholar 

  • DJ Taatjes TH Koch (2001) ArticleTitleNuclear targeting and retention of antracycline antitumor durgs in sensitive and resistant tumor cells Curr Med Chem 8 15–29 Occurrence Handle11172689 Occurrence Handle1:CAS:528:DC%2BD3MXhtVSgsbs%3D

    PubMed  CAS  Google Scholar 

  • T Tamura N Tamura Z Cejka R Hegerl F Lottspeich W Baumeister (1996) ArticleTitleTricorn protease – the core of a modular protelytic system Science 274 1385–1389 Occurrence Handle8910281 Occurrence Handle1:CAS:528:DyaK28XntFKlsrY%3D

    PubMed  CAS  Google Scholar 

  • N Tanahashi K Yokota JY Ahn CH Chung T Fujiwara E Takahashi GN DeMartino CA Slaughter T Toyonaga K Yamamura N Shimbara K Tanaka (1997) ArticleTitleMolecular properties of the proteasome activator PA 28 family proteins and gamma-interferon regulation Genes Cells 2 195–211 Occurrence Handle9189757 Occurrence Handle1:CAS:528:DyaK2sXjsF2gsLs%3D

    PubMed  CAS  Google Scholar 

  • K Tanaka M Kasahara (1998) ArticleTitleThe MHC Class I ligand-generationg system: roles of immunoproteasomes and the interferon-gamma-inducible proteasome activator PA28 Immunol Rev 163 161–176 Occurrence Handle9700509 Occurrence Handle1:CAS:528:DyaK1cXlsVeru78%3D

    PubMed  CAS  Google Scholar 

  • B Tomkinson (1999) ArticleTitleTripeptidyl peptidases: enzymes that count Trends Biochem Sci 24 355–359 Occurrence Handle10470035 Occurrence Handle1:CAS:528:DyaK1MXls1ygur0%3D

    PubMed  CAS  Google Scholar 

  • O Ullrich T Grune (2001) ArticleTitleProteasomal degradation of oxidativly damaged endogenous histones in K562 human leukemic cells Free Radic Biol Med 31 887–893 Occurrence Handle11585707 Occurrence Handle1:CAS:528:DC%2BD3MXnt1Sgs74%3D

    PubMed  CAS  Google Scholar 

  • O Ullrich T Reinheckel N Sitte T Grune (1999a) ArticleTitleDegradation of hypochlorite-damaged glucose-6-phosphate dehydrogenase by the 20S proteasome Free Radic Biol Med 27 487–492 Occurrence Handle1:CAS:528:DyaK1MXls12nt74%3D

    CAS  Google Scholar 

  • O Ullrich T Reinheckel N Sitte R Hass T Grune KJ Davies (1999b) ArticleTitlePoly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones Proc Natl Acad Sci USA 96 6223–6228 Occurrence Handle1:CAS:528:DyaK1MXksFKksLg%3D

    CAS  Google Scholar 

  • O Ullrich N Sitte O Sommerburg V Sandig KJ Davies T Grune (1999c) ArticleTitleInfluence of DNA binding on the degradation of oxidized histones by the 20S proteasome Arch Biochem Biophys 362 211–216 Occurrence Handle1:CAS:528:DyaK1MXhtFWgt7c%3D

    CAS  Google Scholar 

  • G Viteri G Carrard I Birlouez-Aragon E Silvia B Friguet (2004) ArticleTitleAge-dependent protein modifications and declining proteasome activity in human lens Arch Biochem Biophys 427 13935–13942

    Google Scholar 

  • MD Vodenicharov MM Ghodgaonkar SS Halappanavar RG Shah GM Shah (2005) ArticleTitleMechanism of early biphasic activation of poly (ADP-ribose) polymerase-1 in response to ultraviolet B radiation J Cell Sci 118 589–599 Occurrence Handle15657079 Occurrence Handle1:CAS:528:DC%2BD2MXhvFKnurw%3D

    PubMed  CAS  Google Scholar 

  • D Voges P Zwickl W Baumeister (1999) ArticleTitleThe 26S proteasome: a molecular machine designed for controlled proteolysis Annu Rev Biochem 68 1015–1068 Occurrence Handle10872471 Occurrence Handle1:CAS:528:DyaK1MXlvFajtLo%3D

    PubMed  CAS  Google Scholar 

  • C Volker AN Lupas (2002) Molecular evolution of proteasomes P Zwickl W Baumeister (Eds) The proteasome-ubiquitin protein degradation pathway Springer Berlin Heidelberg 1–22

    Google Scholar 

  • J Walz T Tamura N Tamura R Grimm W Baumeister AJ Kloster (1997) ArticleTitleTricorn protease exists as an icosahedral supermolecule in vivo Mol Cell 1 59–65 Occurrence Handle9659903 Occurrence Handle1:CAS:528:DyaK1cXlt1Kntw%3D%3D

    PubMed  CAS  Google Scholar 

  • R Wang BT Chait I Wolf RA Kohanski C Cardozo (1999) ArticleTitleLysozyme degradation by the bovine multicatalytic proteinase complex (proteasome): evidence for a nonprocessive mode of degradation Biochemistry 38 14573–14581 Occurrence Handle10545180 Occurrence Handle1:CAS:528:DyaK1MXmsFaqtL4%3D

    PubMed  CAS  Google Scholar 

  • H Wei Q Cai R Rahn X Zhang (1987) ArticleTitleSinglet oxygen involvement in ultraviolet (254 nm) radiation-induced formation of hydroxy-deoxyguanosine in DNA Free Radic Biol Med 23 148–154

    Google Scholar 

  • T Wenzel W Baumeister (1995) ArticleTitleConformational constraints in protein degradation by the 20S proteasome Nature Struct Biol 2 199–204 Occurrence Handle7773788 Occurrence Handle1:CAS:528:DyaK2MXkt1Ortrk%3D

    PubMed  CAS  Google Scholar 

  • FG Whitby EI Masters L Kramer JR Knowlton Y Yao CC Wang CP Hill (2000) ArticleTitleStructural basis for the activation of 20S proteasomes by 11S regulators Nature 408 115–120 Occurrence Handle11081519 Occurrence Handle1:CAS:528:DC%2BD3cXotVaksb4%3D

    PubMed  CAS  Google Scholar 

  • C Willner (2004) ArticleTitleAn overview of the pathophysiology of neurodegenerative disorders Altern Ther Health Med 10 26–34 Occurrence Handle15285272

    PubMed  Google Scholar 

  • LE Wold NS Aberle Suffix2nd J Ren (2005) ArticleTitleDoxorubicin induces cardiomyocyte dysfunction via a p38 MAP kinase-dependent oxidative stress mechanism Cancer Detect Prev 29 294–299 Occurrence Handle15936597 Occurrence Handle1:CAS:528:DC%2BD2MXms1egsbk%3D

    PubMed  CAS  Google Scholar 

  • XY Zhang J Li L Tang (2005a) ArticleTitleCancer-preventive isothiocyanates: dichotomous modulators of oxidative stress Free Radic Biol Med 38 70–77

    Google Scholar 

  • XY Zhang WG Li YJ WU MT Gao (2005b) ArticleTitleAmelioration of doxorubicin-induced myocardial oxidative stress and immunosupression by grape seed proanthocyanidins in tumor-bearing mice J Pharm Pharmacol 57 1043–1052 Occurrence Handle1:CAS:528:DC%2BD2MXotFeis7o%3D

    CAS  Google Scholar 

  • P Zwickl (2002) The 20S proteasome P Zwickl W Baumeister (Eds) The proteasome-ubiquitin protein degradation pathway Springer Berlin Heidelberg 23–42

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Institute of Environmental Medicine, Heinrich Heine University, Duesseldorf, Germany

    P. Voss & T. Grune

Authors
  1. P. Voss
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Grune
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Voss, P., Grune, T. The nuclear proteasome and the degradation of oxidatively damaged proteins. Amino Acids 32, 527–534 (2007). https://doi.org/10.1007/s00726-006-0428-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00726-006-0428-5

Search

Navigation