Summary.
A procedure for the synthesis of enantiopure β3-amino acids from proteinogenic α-amino acids, developed by our group a few years ago, has been modified to enable the production of C-2 fully deuterated, C-protected β3-amino acids and, even more important, the synthesis of valuable deuterium labelled N(Boc)-protected chiral synthons, such as 2-aminoalcohols, 2-aminoiodides, and β3-amino nitriles.
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Caputo, R., Longobardo, L. Enantiopure β3-amino acids-2,2-d2 via homologation of proteinogenic α-amino acids. Amino Acids 32, 401–404 (2007). https://doi.org/10.1007/s00726-006-0384-0
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DOI: https://doi.org/10.1007/s00726-006-0384-0