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Domino reactions with fluorinated five-membered heterocycles. α-Trifluoromethyl α-amino acids with unsaturated side-chains

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Summary.

α-Trifluoromethyl α-amino acids with unsaturated side-chains have been prepared from 5-fluoro-4-trifluoromethyloxazole and allyl, propargyl as well as terpene alcohols in a one-pot procedure.

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Abbreviations

Tfm Gly:

Trifluoromethylglycine

Mag:

Methylallylglycine

Tfmag:

Trifluoromethylallyl-glycine

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Authors and Affiliations

  1. Department of Organic Chemistry, University of Leipzig, Leipzig, Germany

    K. Burger, L. Hennig & P. Tsouker

  2. Institut de Recerca Biomédica de Barcelona, Parc Cientific Barcelona, Barcelona, Spain

    J. Spengler & F. Albericio

  3. Department of Chemistry, FU Berlin, Berlin, Germany

    B. Koksch

Authors
  1. K. Burger
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  2. L. Hennig
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  3. P. Tsouker
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  4. J. Spengler
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  5. F. Albericio
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  6. B. Koksch
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Burger, K., Hennig, L., Tsouker, P. et al. Domino reactions with fluorinated five-membered heterocycles. α-Trifluoromethyl α-amino acids with unsaturated side-chains. Amino Acids 31, 427–433 (2006). https://doi.org/10.1007/s00726-006-0321-2

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  • DOI: https://doi.org/10.1007/s00726-006-0321-2

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