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Nitric oxide and polyamine pathway-dependent modulation of neutrophil free amino- and α-keto acid profiles or host defense capability

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Summary.

We have examined the effects of Nω-nitro-L-arginine-methylester-hydrochloride [L-NAME; inhibitor of nitric oxide synthase], S-nitroso-N-acetyl-penicillamine [SNAP; nitric oxide donor], α-difluoro-methyl-ornithine [DFMO; inhibitor of ornithine decarboxylase] arginine or ornithine as well as the combination of arginine or ornithine with L-NAME, SNAP or DFMO on intracellular free amino- and α-keto acid profiles and the immune function markers superoxide anion and hydrogen peroxide generation as well as released myeloperoxidase activity in neutrophils (PMN). Although the underlying mechanisms still remain unclear, we believe from our results that nitric oxide as well as polyamine-dependent pathways are involved in the signal transmission of free radical molecule, beneficial nutritional therapy or maleficient pharmacological stress-induced alterations in PMN nutrient composition. Relevant changes in intragranulocyte free amino- and α-keto acid homeostasis and metabolism, especially, may be one of the determinants in PMN nutrition that positively or negatively influences and modulate neutrophil host defence capability and immunocompetence.

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Authors and Affiliations

  1. Department of Anaesthesiology, Intensive Care Medicine, Pain Therapy, University Hospital Giessen and Marburg, Giessen, Federal Republic of Germany

    J. Mühling, J. Engel, M. Halabi, M. Müller, H. Harbach, T. W. Langefeld, M. Wolff, R. Matejec, I. D. Welters, T. Menges & G. Hempelmann

  2. Dr. Ing. Herbert Knauer GmbH, Berlin, Federal Republic of Germany

    M. Fuchs

  3. Department of Internal Medicine/Infectious Diseases, Charité, Medical School of Humboldt University, Berlin, Federal Republic of Germany

    M. Krüll

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  1. J. Mühling
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  2. J. Engel
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  3. M. Halabi
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  4. M. Müller
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Mühling, J., Engel, J., Halabi, M. et al. Nitric oxide and polyamine pathway-dependent modulation of neutrophil free amino- and α-keto acid profiles or host defense capability. Amino Acids 31, 11–26 (2006). https://doi.org/10.1007/s00726-006-0273-6

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