Summary.
Radioactive isotopes are uniquely applicable to observe reactions or circuits of reactions at the molecular level without disturbing the system being studied. The advent of molecular imaging modalities, particularly positron emission tomography (PET), is a major breakthrough for the visualisation and quantitative assessment of cellular and molecular processes occurring in living tissues. The recent development of animal PET scanners that offers 2-mm resolution and is tailored to laboratory rodent models, has made a further great impact on in vivo biochemistry. With these live-imaging modalities at hand, radiotracer-based technologies allow to look directly at biochemical distribution and interaction processes. Tremendous progress made in radiotracer chemistry, primarily in carbon-11 and fluorine-18 radiochemistry, and in the design of imaging devices strengthens the usefulness of radiotracers in nuclear medicine and drug research and development and opens exciting opportunities for new applications, e.g., in food science.
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References
JR Barrio SC Huang WP Melega DC Yu JM Hoffman JS Schneider N Satyamurthy JC Mazziotta ME Phelps (1990) ArticleTitle6-[18F]fluoro-L-dopa probes dopamine turnover rates in central dopaminergic structures. J Neurosci Res 27 487–493 Occurrence Handle2127807 Occurrence Handle10.1002/jnr.490270408 Occurrence Handle1:CAS:528:DyaK3MXhtFOrsb8%3D
M Bergstrom R Awad S Estrada J Malman L Lu G Lendvai E Bergstrom-Pettermann B Langstrom (2003) ArticleTitleAutoradiography with positron emitting isotopes in positron emission tomography tracer discovery. Mol Imaging Biol 5 390–396 Occurrence Handle14667493
SH Britz-Cunningham SJ Adelstein (2003) ArticleTitleMolecular targeting with radionuclides: state of the science. J Nucl Med 44 1945–1961 Occurrence Handle14660721 Occurrence Handle1:CAS:528:DC%2BD2cXjt1SgtA%3D%3D
AF Chatziioannou (2002) ArticleTitlePET scanners dedicated to molecular imaging of small animal models. Mol Imaging Biol 4 47–63 Occurrence Handle14538048
HR Herschman (2003) ArticleTitleMolecular imaging: looking at problems, seeing solutions. Science 302 605–608 Occurrence Handle14576425 Occurrence Handle10.1126/science.1090585 Occurrence Handle1:CAS:528:DC%2BD3sXotlWqtLY%3D
G de Hevesy (1940) ArticleTitleApplication of radioactive indicators in biology. Ann Rev Biochem 9 641–662
AH Jacobs H Li A Winkeler R Hilker C Knoess A Ruger N Galldiks B Schaller J Sobesky L Kracht P Monfared M Klein S Vollmar B Bauer R Wagner R Graf K Wienhard K Herholz WD Heiss (2003) ArticleTitlePET-based molecular imaging in neuroscience. Eur J Nucl Med Mol Imaging 30 1051–1065 Occurrence Handle12764552 Occurrence Handle10.1007/s00259-003-1202-5 Occurrence Handle1:STN:280:DC%2BD3svhsFehug%3D%3D
G Jerusalem R Hustinx Y Beguin G Fillet (2003) ArticleTitlePET scan imaging in oncology. Eur J Cancer 39 1525–1534 Occurrence Handle12855258 Occurrence Handle10.1016/S0959-8049(03)00374-5 Occurrence Handle1:STN:280:DC%2BD3szisFykug%3D%3D
JS Lewis S Achilefu JR Garbow R Laforest MJ Welch (2002) ArticleTitleSmall animal imaging. Current technology and perspectives for oncological imaging. Eur J Cancer 38 2173–2188 Occurrence Handle12387842 Occurrence Handle10.1016/S0959-8049(02)00394-5
KP Lindsey SJ Gatley ND Volkow (2003) ArticleTitleNeuroimaging in drug abuse. Curr Psychiatry Rep 5 355–361 Occurrence Handle13678555
D Maclean JP Northrop HC Padgett JC Walsh (2003) ArticleTitleDrugs and probes: the symbiotic relationship between pharmaceutical discovery and imaging science. Mol Imaging Biol 5 304–311 Occurrence Handle14630510
RV Parsey JJ Mann (2003) ArticleTitleApplications of positron emission tomography in psychiatry. Semin Nucl Med 33 129–135 Occurrence Handle12756645 Occurrence Handle10.1053/snuc.2003.127302
ME Phelps (2000) ArticleTitlePET: the merging of biology and imaging into molecular imaging. J Nucl Med 41 661–681 Occurrence Handle10768568 Occurrence Handle1:STN:280:DC%2BD3c3ivFSmtw%3D%3D
M Schwaiger FM Bengel (2002) ArticleTitleFrom thallium scan to molecular imaging. Mol Imaging Biol 4 387–398 Occurrence Handle14537103
G Stoecklin SM Qaim F Roesch (1995) ArticleTitleThe impact of radioactivity on medicine. Radiochim Acta 70/71 249–272
Schoenheimer R (1942) The dynamic state of body constituents. Harvard University Press, Cambridge, MA
R Schoenheimer D Rittenberg (1938) ArticleTitleThe application of isotopes to the study of intermediary metabolism. Science 87 221–226 Occurrence Handle1:CAS:528:DyaA1cXjtVamtw%3D%3D
MM Ter-Pogossian (1966) ArticleTitleCyclotron produced short-lived radioactive isotopes. Am J Roentgenol Radium Ther Nucl Med 96 737–743 Occurrence Handle5904885 Occurrence Handle1:CAS:528:DyaF28XkvFansL0%3D
ND Volkow GJ Wang S Dewey (1999) ArticleTitlePET and drug research and development. J Nucl Med 40 1154–1163 Occurrence Handle10405137
ND Volkow JS Fowler GJ Wang (2003) ArticleTitlePositron emission tomography and single-photon emission computed tomography in substance abuse research. Semin Nucl Med 33 114–128 Occurrence Handle12756644 Occurrence Handle10.1053/snuc.2003.127300
R Weissleder U Mahmood (2001) ArticleTitleMolecular imaging. Radiology 219 316–333 Occurrence Handle11323453 Occurrence Handle1:CAS:528:DC%2BD3MXjs1ekur0%3D
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Johannsen, B. The usefulness of radiotracers to make the body biochemically transparent. Amino Acids 29, 307–311 (2005). https://doi.org/10.1007/s00726-005-0199-4
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DOI: https://doi.org/10.1007/s00726-005-0199-4