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Pseudo-peptides derived from isomannide as potential inhibitors of serine proteases

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Summary.

Hepatitis C, Dengue and West Nile virus are among of the most important flaviviruses that share one important serine protease enzyme. Serine proteases belong to the most studied class of proteolytic enzymes, and are a primary target in the drug development field. In this paper, we describe the synthesis and preliminary molecular modeling studies of a novel class of N-t-Boc amino acid amides derived of isomannide as potential serine proteases inhibitors.

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Authors and Affiliations

  1. Instituto de Química, Universidade do Brasil, Cidade Universitária, CT Bloco A, Rio de Janeiro, Brasil

    E. M. F. Muri, M. Gomes Jr., M. G. Albuquerque, E. F. F. da Cunha, R. B. de Alencastro & O. A. C. Antunes

  2. Faser Hall, School of Pharmacy, Department of Medicinal Chemistry, University of Mississippi, Mississippi, U.S.A.

    J. S. Williamson

Authors
  1. E. M. F. Muri
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  2. M. Gomes Jr.
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  3. M. G. Albuquerque
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  4. E. F. F. da Cunha
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  5. R. B. de Alencastro
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  6. J. S. Williamson
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  7. O. A. C. Antunes
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Muri, E., Gomes, M., Albuquerque, M. et al. Pseudo-peptides derived from isomannide as potential inhibitors of serine proteases. Amino Acids 28, 413–419 (2005). https://doi.org/10.1007/s00726-004-0146-9

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  • DOI: https://doi.org/10.1007/s00726-004-0146-9

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